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Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions Downloaded from https://academic.oup.com/edrv/article-abstract/16/1/3/2548486 by guest on 15 October 2019 0163-769X/95/$03.00/0 Vol. 16, No. 1 Printed in U.S.A. Endocrine Reviews Copyright © 1995 by The Endocrine Society Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions* JOHN I. JONES AND DAVID R. CLEMMONS Division of Endocrinology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7170 I. Introduction I. Introduction HE insulin-like growth factors were discovered on the II. Signal Transduction via IGF Receptors T basis of their ability to stimulate cartilage sulf ation and A. IGF-I receptor to replace the "sulfation factor activity" of GH, as determined 1. Extracellular domain/ligand binding using an in vivo assay, in an in vitro test system (1). The 2. Cytoplasmic domain biological significance of this finding was quickly expanded 3. Signal transduction beyond the study of cartilage sulf ation to include stimulation 4. Hybrid insulin/IGF-I receptors of DNA synthesis (2), proteoglycan synthesis (3), glycosami- B. IGF-II/mannose-6-phosphate receptor noglycan synthesis (4), and protein synthesis (5). Most of 1. Ligand binding these studies used tissue preparations such as isolated dia- 2. Deletion of IGF-II receptor/parental imprinting phragm, cartilage, or epididymal fat pads to study biological 3. Possible signaling functions activity. In recognition of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Endocrine Reviews Oxford University Press

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions

Jones, John, I.; Clemmons, David, R.
Endocrine Reviews , Volume 16 (1) – Feb 1, 1995
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Publisher
Oxford University Press
Copyright
Copyright © 1995 by The Endocrine Society
ISSN
0163-769X
eISSN
1945-7189
DOI
10.1210/edrv-16-1-3
Publisher site
See Article on Publisher Site

Abstract

Downloaded from https://academic.oup.com/edrv/article-abstract/16/1/3/2548486 by guest on 15 October 2019 0163-769X/95/$03.00/0 Vol. 16, No. 1 Printed in U.S.A. Endocrine Reviews Copyright © 1995 by The Endocrine Society Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions* JOHN I. JONES AND DAVID R. CLEMMONS Division of Endocrinology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7170 I. Introduction I. Introduction HE insulin-like growth factors were discovered on the II. Signal Transduction via IGF Receptors T basis of their ability to stimulate cartilage sulf ation and A. IGF-I receptor to replace the "sulfation factor activity" of GH, as determined 1. Extracellular domain/ligand binding using an in vivo assay, in an in vitro test system (1). The 2. Cytoplasmic domain biological significance of this finding was quickly expanded 3. Signal transduction beyond the study of cartilage sulf ation to include stimulation 4. Hybrid insulin/IGF-I receptors of DNA synthesis (2), proteoglycan synthesis (3), glycosami- B. IGF-II/mannose-6-phosphate receptor noglycan synthesis (4), and protein synthesis (5). Most of 1. Ligand binding these studies used tissue preparations such as isolated dia- 2. Deletion of IGF-II receptor/parental imprinting phragm, cartilage, or epididymal fat pads to study biological 3. Possible signaling functions activity. In recognition of

Journal

Endocrine Reviews – Oxford University Press

Published: Feb 1, 1995

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