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Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits

Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction... Behav Genet (2012) 42:1–2 DOI 10.1007/s10519-011-9504-z BRIEF COMMUNICATION Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits John K. Hewitt Received: 6 September 2011 / Accepted: 8 September 2011 / Published online: 18 September 2011 Springer Science+Business Media, LLC 2011 The literature on candidate gene associations is full of studies of complex traits, especially when reporting com- reports that have not stood up to rigorous replication. This plex interaction effects based on novel phenotypes and is the case both for straightforward main effects and for groupings. Of course, we understand that this has not been candidate gene-by-environment interactions (Duncan and done routinely—sometimes it is not practical—and so Keller 2011). As a result, the psychiatric and behavior authors have preferred to publish the initial paper without genetics literature has become confusing and it now seems such replication. We also recognize that there are historical likely that many of the published findings of the last decade examples where early failures to replicate were themselves are wrong or misleading and have not contributed to real misleading because of heterogeneity or poor methodology. advances in knowledge. The reasons for this are complex, However, for a candidate gene or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavior Genetics Springer Journals

Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits

Hewitt, John
Behavior Genetics , Volume 42 (1) – Sep 18, 2011
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References (5)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer Science+Business Media, LLC
Subject
Psychology; Clinical Psychology; Health Psychology; Public Health
ISSN
0001-8244
eISSN
1573-3297
DOI
10.1007/s10519-011-9504-z
pmid
21928046
Publisher site
See Article on Publisher Site

Abstract

Behav Genet (2012) 42:1–2 DOI 10.1007/s10519-011-9504-z BRIEF COMMUNICATION Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits John K. Hewitt Received: 6 September 2011 / Accepted: 8 September 2011 / Published online: 18 September 2011 Springer Science+Business Media, LLC 2011 The literature on candidate gene associations is full of studies of complex traits, especially when reporting com- reports that have not stood up to rigorous replication. This plex interaction effects based on novel phenotypes and is the case both for straightforward main effects and for groupings. Of course, we understand that this has not been candidate gene-by-environment interactions (Duncan and done routinely—sometimes it is not practical—and so Keller 2011). As a result, the psychiatric and behavior authors have preferred to publish the initial paper without genetics literature has become confusing and it now seems such replication. We also recognize that there are historical likely that many of the published findings of the last decade examples where early failures to replicate were themselves are wrong or misleading and have not contributed to real misleading because of heterogeneity or poor methodology. advances in knowledge. The reasons for this are complex, However, for a candidate gene or

Journal

Behavior Genetics – Springer Journals

Published: Sep 18, 2011

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