Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The Tumor MicroenvironmentMeasuring Vascular Permeability In Vivo

The Tumor Microenvironment: Measuring Vascular Permeability In Vivo [Over the past decades, in vivo vascular permeability measurements have provided significant insight into vascular functions in physiological and pathophysiological conditions such as the response to pro- and anti-angiogenic signaling, abnormality of tumor vasculature and its normalization, and delivery and efficacy of therapeutic agents. Different approaches for vascular permeability measurements have been established. Here, we describe and discuss a conventional 2D imaging method to measure vascular permeability, which was originally documented by Gerlowski and Jain in 1986 (Microvasc Res 31:288–305, 1986) and further developed by Yuan et al. in the early 1990s (Microvasc Res 45:269–289, 1993; Cancer Res 54:352–3356, 1994), and our recently developed 3D imaging method, which advances the approach originally described by Brown et al. in 2001 (Nat Med 7:864–868, 2001).] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

The Tumor MicroenvironmentMeasuring Vascular Permeability In Vivo

Part of the Methods in Molecular Biology Book Series (volume 1458)
Editors: Ursini-Siegel, Josie; Beauchemin, Nicole
Meijer, Eelco F. J.; Baish, James W.; Padera, Timothy P.; Fukumura, Dai
The Tumor Microenvironment — Sep 1, 2016
Download PDF
14 pages

 
/lp/springer-journals/the-tumor-microenvironment-measuring-vascular-permeability-in-vivo-xbCUdo1qoS

References (36)

Publisher
Springer New York
Copyright
© Springer Science+Business Media New York 2016
ISBN
978-1-4939-3799-8
Pages
71–85
DOI
10.1007/978-1-4939-3801-8_6
Publisher site
See Chapter on Publisher Site

Abstract

[Over the past decades, in vivo vascular permeability measurements have provided significant insight into vascular functions in physiological and pathophysiological conditions such as the response to pro- and anti-angiogenic signaling, abnormality of tumor vasculature and its normalization, and delivery and efficacy of therapeutic agents. Different approaches for vascular permeability measurements have been established. Here, we describe and discuss a conventional 2D imaging method to measure vascular permeability, which was originally documented by Gerlowski and Jain in 1986 (Microvasc Res 31:288–305, 1986) and further developed by Yuan et al. in the early 1990s (Microvasc Res 45:269–289, 1993; Cancer Res 54:352–3356, 1994), and our recently developed 3D imaging method, which advances the approach originally described by Brown et al. in 2001 (Nat Med 7:864–868, 2001).]

Published: Sep 1, 2016

Keywords: Vascular permeability; Intravital fluorescence microscopy; Vascular normalization; Multiphoton microscopy

There are no references for this article.