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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature... Dendritic cells (DCs) can promote or inhibit T cell responses. Grogan and colleagues show that the T cell protein TIGIT, by engaging poliovirus receptor on DCs, promotes DC interleukin 10 production, which inhibits T cell activation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Immunology Springer Journals

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

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References (54)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
ISSN
1529-2908
eISSN
1529-2916
DOI
10.1038/ni.1674
Publisher site
See Article on Publisher Site

Abstract

Dendritic cells (DCs) can promote or inhibit T cell responses. Grogan and colleagues show that the T cell protein TIGIT, by engaging poliovirus receptor on DCs, promotes DC interleukin 10 production, which inhibits T cell activation.

Journal

Nature ImmunologySpringer Journals

Published: Nov 16, 2008

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