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Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior

Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic... The Journal of Neuroscience, May 1, 2003 • 23(9):3837–3843 • 3837 Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior 1 2 2 1 3 3 Sarah L. King, Michael J. Marks, Sharon R. Grady, Barbara J. Caldarone, Andrei O. Koren, Alexey G. Mukhin, 2 1 Allan C. Collins, and Marina R. Picciotto 1 2 Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, and Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224 Prenatal nicotine exposure has been linked to attention deficit hyperactivity disorder and cognitive impairment, but the sites of action for these effects of nicotine are still under investigation. High-affinity nicotinic acetylcholine receptors (nAChRs) contain the2 subunit and modulate passive avoidance (PA) learning in mice. Using an inducible, tetracycline-regulated transgenic system, we generated lines of mice with expression of high-affinity nicotinic receptors restored in specific neuronal populations. One line of mice shows functional 2 subunit-containing nAChRs localized exclusively in corticothalamic efferents. Functional, presynaptic nAChRs are present in the thala- mus of these mice as detected by nicotine-elicited rubidium http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroscience Unpaywall

Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior

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Publisher
Unpaywall
ISSN
0270-6474
DOI
10.1523/jneurosci.23-09-03837.2003
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Abstract

The Journal of Neuroscience, May 1, 2003 • 23(9):3837–3843 • 3837 Conditional Expression in Corticothalamic Efferents Reveals a Developmental Role for Nicotinic Acetylcholine Receptors in Modulation of Passive Avoidance Behavior 1 2 2 1 3 3 Sarah L. King, Michael J. Marks, Sharon R. Grady, Barbara J. Caldarone, Andrei O. Koren, Alexey G. Mukhin, 2 1 Allan C. Collins, and Marina R. Picciotto 1 2 Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, and Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224 Prenatal nicotine exposure has been linked to attention deficit hyperactivity disorder and cognitive impairment, but the sites of action for these effects of nicotine are still under investigation. High-affinity nicotinic acetylcholine receptors (nAChRs) contain the2 subunit and modulate passive avoidance (PA) learning in mice. Using an inducible, tetracycline-regulated transgenic system, we generated lines of mice with expression of high-affinity nicotinic receptors restored in specific neuronal populations. One line of mice shows functional 2 subunit-containing nAChRs localized exclusively in corticothalamic efferents. Functional, presynaptic nAChRs are present in the thala- mus of these mice as detected by nicotine-elicited rubidium

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Journal of Neuroscience – Unpaywall

Published: May 1, 2003

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