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How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the... The antigen-specific receptors of T lymphocytes rely on products of the major histocompatibility complex (MHC) to recognize and engage antigen. MHC molecules display antigen on the cell surface in the form of small peptides, generated intracellularly by fragmentation of the intact protein antigen. They acquire these peptides at distinct intracellular locations: In the endoplasmic reticulum (ER), class I molecules bind peptides derived from cytosolic pro­ teins, whereas class II molecules acquire their peptide cargo in an endocytic compartment. Sequestration of class II molecules from the constitutive secre­ tory pathway is mediated by their interaction with an additional polypeptide, the invariant chain (Ii). The Ii contains sorting signals in its cytoplasmic tail that target class II molecules to the endocytic pathway where they encounter peptides generated from protein antigens that have also accessed this route. INTRODUCTION The vertebrate immune system has evolved two distinct types of antigen-spe­ cific receptors to help eliminate extracellular and intracellular pathogens: sol­ uble receptors, known as antibodies (or immunoglobulins), and a receptor on the cell surface of T lymphocytes, the T-cell receptor (TCR). Antibodies secreted into the extracellular environment recognize and eliminate their target antigens independently of any third party molecule: The presence of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cell and Developmental Biology Annual Reviews

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

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References (56)

Publisher
Annual Reviews
Copyright
Copyright 1995 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
1081-0706
eISSN
1530-8995
DOI
10.1146/annurev.cb.11.110195.001411
pmid
8689559
Publisher site
See Article on Publisher Site

Abstract

The antigen-specific receptors of T lymphocytes rely on products of the major histocompatibility complex (MHC) to recognize and engage antigen. MHC molecules display antigen on the cell surface in the form of small peptides, generated intracellularly by fragmentation of the intact protein antigen. They acquire these peptides at distinct intracellular locations: In the endoplasmic reticulum (ER), class I molecules bind peptides derived from cytosolic pro­ teins, whereas class II molecules acquire their peptide cargo in an endocytic compartment. Sequestration of class II molecules from the constitutive secre­ tory pathway is mediated by their interaction with an additional polypeptide, the invariant chain (Ii). The Ii contains sorting signals in its cytoplasmic tail that target class II molecules to the endocytic pathway where they encounter peptides generated from protein antigens that have also accessed this route. INTRODUCTION The vertebrate immune system has evolved two distinct types of antigen-spe­ cific receptors to help eliminate extracellular and intracellular pathogens: sol­ uble receptors, known as antibodies (or immunoglobulins), and a receptor on the cell surface of T lymphocytes, the T-cell receptor (TCR). Antibodies secreted into the extracellular environment recognize and eliminate their target antigens independently of any third party molecule: The presence of

Journal

Annual Review of Cell and Developmental Biology – Annual Reviews

Published: Nov 1, 1995

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