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The ionic requirements for the production of action potentials in crustacean muscle fibres

The ionic requirements for the production of action potentials in crustacean muscle fibres J. Physiol. (I958) 142, 5I6-543 THE IONIC FOR THE PRODUCTION OF REQUIREMENTS ACTION POTENTIALS IN CRUSTACEAN MUSCLE FIBRES AND BY P. FATT B. L. GINSBORG* From the London Department of Biophysics, University College (Received 19 March 1958) has shown that the action the It been potential of axon of the giant squid arises as a result of a which on the regenerative process depends permeability of its surface membrane to sodium ions controlled the membrane being by potential (Hodgkin & 1952 From the Huxley, b). relationship obtaining between the of the action the amplitude potential and concentration of sodium ions in the this mode of of the action surrounding solution, production potential has been inferred to apply also to vertebrate striated muscle (Nastuk & Hodgkin, and nerve & 1950) myelinated (Huxley Stampfli, 1951). It does not, to crustacean muscle however, apply fibres, which, while giving feeble, frequently non-propagating in their normal responses environment, containing a high of concentration sodium, produce large, prolonged action potentials when the sodium is replaced by ammonium ions quaternary (Fatt & Katz, It has 1953). further been observed that some ions (e.g. tetra-n-butylam- monium) have an irreversible action: after a muscle has in been a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

The ionic requirements for the production of action potentials in crustacean muscle fibres

Fatt, P.; Ginsborg, B. L.
The Journal of Physiology , Volume 142 (3) – Jan 6, 1958
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References (15)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1958.sp006034
Publisher site
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Abstract

J. Physiol. (I958) 142, 5I6-543 THE IONIC FOR THE PRODUCTION OF REQUIREMENTS ACTION POTENTIALS IN CRUSTACEAN MUSCLE FIBRES AND BY P. FATT B. L. GINSBORG* From the London Department of Biophysics, University College (Received 19 March 1958) has shown that the action the It been potential of axon of the giant squid arises as a result of a which on the regenerative process depends permeability of its surface membrane to sodium ions controlled the membrane being by potential (Hodgkin & 1952 From the Huxley, b). relationship obtaining between the of the action the amplitude potential and concentration of sodium ions in the this mode of of the action surrounding solution, production potential has been inferred to apply also to vertebrate striated muscle (Nastuk & Hodgkin, and nerve & 1950) myelinated (Huxley Stampfli, 1951). It does not, to crustacean muscle however, apply fibres, which, while giving feeble, frequently non-propagating in their normal responses environment, containing a high of concentration sodium, produce large, prolonged action potentials when the sodium is replaced by ammonium ions quaternary (Fatt & Katz, It has 1953). further been observed that some ions (e.g. tetra-n-butylam- monium) have an irreversible action: after a muscle has in been a

Journal

The Journal of Physiology – Wiley

Published: Jan 6, 1958

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