Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Bjørn, N. Hastrup, J. Larsen, Leif Lund, Charles Pyke (2000)
Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester.Placenta, 21 2-3
K. Lehti, J. Lohi, Heli Valtanen, J. Keski‐oja (1998)
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface.The Biochemical journal, 334 ( Pt 2)
P. Brown, R. Bloxidge, N. Stuart, Kevin Galler, J. Carmichael (1993)
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma.Journal of the National Cancer Institute, 85 7
Polette (1996)
MT-MMP expression and localisation in human lung and breast cancersVirchows Arch, 428
Jian Cao, A. Rehemtulla, W. Bahou, S. Zucker (1996)
Membrane Type Matrix Metalloproteinase 1 Activates Pro-gelatinase A without Furin Cleavage of the N-terminal Domain*The Journal of Biological Chemistry, 271
R. Ward, S. Atkinson, J. Reynolds, Gillian Murphy (1994)
Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts.The Biochemical journal, 304 ( Pt 1)
Yasunori OkadaSQ, Hideaki NagaseST, E. Harris (1986)
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.The Journal of biological chemistry, 261 30
T. Takino, Hiroshi Sato, Etsuhide Yamamoto, M. Seiki (1995)
Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain.Gene, 155 2
M. d’Ortho, H. Will, S. Atkinson, G. Butler, A. Messent, J. Gavrilovic, Bryan Smith, R. Timpl, L. Zardi, G. Murphy (1997)
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.European journal of biochemistry, 250 3
H. Nomura, Hiroshi Sato, M. Seiki, M. Mai, Y. Okada (1995)
Expression of membrane-type matrix metalloproteinase in human gastric carcinomas.Cancer research, 55 15
Y. Itoh, A. Ito, K. Iwata, K. Tanzawa, Y. Mori, H. Nagase (1998)
Plasma Membrane-bound Tissue Inhibitor of Metalloproteinases (TIMP)-2 Specifically Inhibits Matrix Metalloproteinase 2 (Gelatinase A) Activated on the Cell Surface*The Journal of Biological Chemistry, 273
K. Hotary, E. Allen, A. Punturieri, I. Yana, S. Weiss (2000)
Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3The Journal of Cell Biology, 149
H. Miyamori, T. Takino, M. Seiki, Hiroshi Sato (2000)
Human membrane type-2 matrix metalloproteinase is defective in cell-associated activation of progelatinase A.Biochemical and biophysical research communications, 267 3
J. Lohi, K. Lehti, J. Westermarck, V. Kähäri, J. Keski‐oja (1996)
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.European journal of biochemistry, 239 2
Zhiping Wang, Ruth Juttermann, P. Soloway (2000)
TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo *The Journal of Biological Chemistry, 275
Z. Werb (1997)
ECM and Cell Surface Proteolysis: Regulating Cellular EcologyCell, 91
T. Harada, S. Arii, M. Mise, T. Imamura, H. Higashitsuji, Masahara Furutani, M. Niwano, S. Ishigami, M. Fukumoto, M. Seiki, Hiroshi Sato, M. Imamura (1998)
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.Journal of hepatology, 28 2
M. Roderfeld, F. Büttner, E. Bartnik, H. Tschesche (2000)
Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris.Protein expression and purification, 19 3
Hiroshi Sato, T. Takino, Y. Okada, Jian Cao, A. Shinagawa, Etsuhide Yamamoto, M. Seiki (1994)
A matrix metalloproteinase expressed on the surface of invasive tumour cellsNature, 370
G. Butler, M. Butler, S. Atkinson, H. Will, T. Tamura, S. Westrum, T. Crabbe, J. Clements, M. d’Ortho, G. Murphy (1998)
The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase AThe Journal of Biological Chemistry, 273
M. Mattei, N. Roeckel, Björn Olsen, S. Apte, S. Apte (1997)
Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively.Genomics, 40 1
A. Nichols, T. Itoh, J. Graham, Wei Liu, M. Yamaizumi, S. Linn (2000)
Human Damage-specific DNA-binding Protein p48The Journal of Biological Chemistry, 275
H. Kanayama, K. Yokota, Y. Kurokawa, Y. Murakami, M. Nishitani, S. Kagawa (1998)
Prognostic values of matrix metalloproteinase‐2 and tissue inhibitor of metalloproteinase‐2 expression in bladder cancerCancer, 82
R. Ward, S. Atkinson, P. Slocombe, A. Docherty, J. Reynolds, Gillian Murphy (1991)
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.Biochimica et biophysica acta, 1079 2
J. Caterina, S. Yamada, N. Caterina, G. Longenecker, K. Holmbäck, Joanne Shi, Audra Yermovsky, J. Engler, H. Birkedal‐Hansen (2000)
Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation*The Journal of Biological Chemistry, 275
A. Okada, C. Tomasetto, Y. Lutz, J. Bellocq, M. Rio, P. Basset (1997)
Expression of Matrix Metalloproteinases during Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase Is a Stromal Activator of Pro-Gelatinase AThe Journal of Cell Biology, 137
H. Ohtani, H. Motohashi, Hiroshi Sato, M. Seiki, H. Nagura (1996)
Dual over‐expression pattern of membrane‐type metalloproteinase‐1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopyInternational Journal of Cancer, 68
I. Yana, Stephen Weiss (2000)
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.Molecular biology of the cell, 11 7
Hiroshi Sato, Masaaki Tanaka, T. Takino, M. Inoue, Motoharu Seiki (1997)
Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.Genomics, 39 3
Hiroshi Sato, T. Takino, T. Kinoshita, K. Imai, Y. Okada, William Stevenson, M. Seiki (1996)
Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)FEBS Letters, 385
J. Lohi, J. Lohi, K. Lehti, Heli Valtanen, W. Parks, J. Keski‐oja (2000)
Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.Gene, 242 1-2
N. Hiraoka, E. Allen, I. Apel, M. Gyetko, S. Weiss (1998)
Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular FibrinolysinsCell, 95
B. Nawrocki, M. Polette, V. Marchand, M. Monteau, P. Gillery, J. Tournier, P. Birembaut (1997)
Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analysesInternational Journal of Cancer, 72
J. Upadhyay, B. Shekarriz, J. Nemeth, Z. Dong, Glenn Cummings, R. Fridman, W. Sakr, D. Grignon, M. Cher (1999)
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.Clinical cancer research : an official journal of the American Association for Cancer Research, 5 12
(1997)
MT 1 - MMP correlates with MMP - 2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells
M. Tokuraku, Hiroshi Sato, Sinya Murakami, Y. Okada, Yoh Watanabe, M. Seiki (1995)
Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP‐2 in lung carcinomas correlates with the expression of membrane‐type matrix metalloproteinase (MT‐MMP) and with lymph node metastasisInternational Journal of Cancer, 64
G. Velasco, S. Cal, A. Merlos-Suárez, A. Ferrando, Sonsoles Alvarez, A. Nakano, J. Arribas, C. López-Otín (2000)
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.Cancer research, 60 4
P. Brooks, S. Strömblad, L. Sanders, T. Schalscha, R. Aimes, W. Stetler-Stevenson, J. Quigley, D. Cheresh (1996)
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Cell, 85 5
D. Pei (1999)
Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP*The Journal of Biological Chemistry, 274
Hiroaki Kinoh, Hiroshi Sato, Y. Tsunezuka, T. Takino, A. Kawashima, Y. Okada, M. Seiki (1996)
MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.Journal of cell science, 109 ( Pt 5)
W. Stetler-Stevenson, L. Liotta, D. Kleiner (1993)
Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasisThe FASEB Journal, 7
Y. Kadono, Kazushige Shibahara, M. Namiki, Yoh Watanabe, M. Seiki, Hiroshi Sato (1998)
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cells.Biochemical and biophysical research communications, 251 3
A. Strongin, I. Collier, G. Bannikov, B. Marmer, G. Grant, G. Goldberg (1995)
Mechanism Of Cell Surface Activation Of 72-kDa Type IV CollagenaseThe Journal of Biological Chemistry, 270
M. Kajita, Hiroaki Kinoh, N. Ito, Akiko Takamura, Y. Itoh, A. Okada, Hiroshi Sato, M. Seiki (1999)
Human membrane type‐4 matrix metalloproteinase (MT4‐MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4‐mmp transcriptsFEBS Letters, 457
A. Strongin, B. Marmer, G. Grant, G. Goldberg (1993)
Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2.The Journal of biological chemistry, 268 19
S. Zucker, U. Moll, R. Lysik, E. Dimassimo, W. Stetler-Stevenson, L. Liotta, J. Schwedes (1990)
Extraction of type‐IV collagenase/gelatinase from plasma membranes of human cancer cellsInternational Journal of Cancer, 45
H. Ueno, H. Ueno, Hiroyuki Nakamura, M. Inoue, K. Imai, Masakuni Noguchi, Hiroshi Sato, Motoharu Seiki, Yasunori Okada (1997)
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.Cancer research, 57 10
(1990)
Pump-I is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases
T. Yoshizaki, Hiroshi Sato, Y. Maruyama, S. Murono, M. Furukawa, C. Park, M. Seiki (1997)
Increased expression of membrane type 1‐matrix metalloproteinase in head and neck carcinomaCancer, 79
K. Shofuda, H. Yasumitsu, A. Nishihashi, K. Miki, K. Miyazaki (1997)
Expression of Three Membrane-type Matrix Metalloproteinases (MT-MMPs) in Rat Vascular Smooth Muscle Cells and Characterization of MT3-MMPs with and without Transmembrane Domain*The Journal of Biological Chemistry, 272
H. Will, S. Atkinson, G. Butler, Bryan Smith, G. Murphy (1996)
The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic ActivationThe Journal of Biological Chemistry, 271
Zhong Dong, Moshira Ghabrial, M. Katar, R. Fridman, Richard Berk (2000)
Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa.Investigative ophthalmology & visual science, 41 13
T. Rajavashisth, J. Liao, Z. Galis, Sangeetika Tripathi, U. Laufs, Jagannath Tripathi, N. Chai, Xiao-ping Xu, S. Jovinge, P. Shah, P. Libby (1999)
Inflammatory Cytokines and Oxidized Low Density Lipoproteins Increase Endothelial Cell Expression of Membrane Type 1-Matrix Metalloproteinase*The Journal of Biological Chemistry, 274
D. Kleiner, W. Stetler-Stevenson (1993)
Structural biochemistry and activation of matrix metalloproteases.Current opinion in cell biology, 5 5
T. Itoh, Masatoshi Tanioka, H. Yoshida, T. Yoshioka, H. Nishimoto, S. Itohara (1998)
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.Cancer research, 58 5
Hiroyuki Nakamura, H. Ueno, K. Yamashita, Taketoshi Shimada, Etsuhide Yamamoto, M. Noguchi, N. Fujimoto, Hiroshi Sato, M. Seiki, Y. Okada (1999)
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.Cancer research, 59 2
David Fishman, Bafetti Lm, Stack Ms (1996)
Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells.Invasion & metastasis, 16 3
Y. Kadono, Y. Okada, M. Namiki, M. Seiki, Hiroshi Sato (1998)
Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness.Cancer research, 58 10
H. Sato, T. Kinoshita, T. Takino, Kazuo Nakayama, M. Seiki (1996)
Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2FEBS Letters, 393
M. Nakajima, D. Lotan, M. Baig, R. Carralero, W. Wood, M. Hendrix, R. Lotan (1989)
Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.Cancer research, 49 7
Zhongjun Zhou, S. Apte, R. Soininen, R. Cao, G. Baaklini, R. Rauser, Jianming Wang, Yihai Cao, K. Tryggvason (2000)
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.Proceedings of the National Academy of Sciences of the United States of America, 97 8
Heather Stanton, J. Gavrilovic, S. Atkinson, M. d’Ortho, K. Yamada, L. Zardi, G. Murphy (1998)
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form.Journal of cell science, 111 ( Pt 18)
Taketoshi Shimada, Taketoshi Shimada, Hiroyuki Nakamura, E. Ohuchi, Yutaka Fujii, Yasushi Murakami, Hiroshi Sato, M. Seiki, Y. Okada (1999)
Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.European journal of biochemistry, 262 3
H. Kolkenbrock, A. Hecker-Kia, D. Orgel, N. Ulbrich, H. Will (1997)
Activation of Progelatinase A and Progelatinase A/TIMP-2 Complex by Membrane Type 2-Matrix Metalloproteinase, 378
George Cross (1990)
Glycolipid anchoring of plasma membrane proteins.Annual review of cell biology, 6
P. Brooks, S. Silletti, T. Schalscha, M. Friedlander, D. Cheresh (1998)
Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding ActivityCell, 92
G. Murphy, J. Gavrilovic (1999)
Proteolysis and cell migration: creating a path?Current opinion in cell biology, 11 5
H. Kolkenbrock, Lutz Essers, N. Ulbrich, H. Will (1999)
Biochemical Characterization of the Catalytic Domain of Membrane-Type 4 Matrix Metalloproteinase, 380
Jiani Cao, Hiroshi Sato, T. Takino, M. Seiki (1995)
The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation (*)The Journal of Biological Chemistry, 270
Yah-li Wang, A. Johnson, Q. Ye, R. Dyer (1999)
Catalytic Activities and Substrate Specificity of the Human Membrane Type 4 Matrix Metalloproteinase Catalytic Domain*The Journal of Biological Chemistry, 274
T. Harayama, E. Ohuchi, T. Aoki, Hiroshi Sato, M. Seiki, Y. Okada (1999)
Shedding of Membrane Type 1 Matrix Metalloproteinase in a Human Breast Carcinoma Cell LineJapanese Journal of Cancer Research : Gann, 90
T. Kinoshita, Hiroshi Sato, T. Takino, M. Itoh, T. Akizawa, M. Seiki (1996)
Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.Cancer research, 56 11
Y. Itoh, M. Kajita, H. Kinoh, H. Mori, A. Okada, M. Seiki (1999)
Membrane Type 4 Matrix Metalloproteinase (MT4-MMP, MMP-17) Is a Glycosylphosphatidylinositol-anchored Proteinase*The Journal of Biological Chemistry, 274
S. Atkinson, T. Crabbe, S. Cowell, R. Ward, M. Butler, Hiroshi Sato, M. Seiki, J. Reynolds, G. Murphy (1995)
Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes (*)The Journal of Biological Chemistry, 270
N. Koshikawa, Gianluigi Giannelli, Vincenzo Cirulli, Kaoru Miyazaki, Vito Quaranta (2000)
Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5The Journal of Cell Biology, 148
Heli Valtanen, K. Lehti, J. Lohi, Jorma Keski-oja (2000)
Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase.Protein expression and purification, 19 1
E. Llano, A. Pendás, J. Freije, A. Nakano, V. Knäuper, G. Murphy, C. López-Otín (1999)
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.Cancer research, 59 11
S. Apte, N. Fukai, D. Beier, B. Olsen (1997)
The Matrix Metalloproteinase-14 (MMP-14) Gene Is Structurally Distinct from Other MMP Genes and Is Co-expressed with the TIMP-2 Gene during Mouse Embryogenesis*The Journal of Biological Chemistry, 272
(1997)
Unaltered secretion of beta - amyloid precursor protein in gelatinase A ( matrix metalloproteinase 2 ) - deficient mice
S. Cowell, V. Knäuper, Margaret Stewart, M. d’Ortho, Heather Stanton, R. Hembry, Carlos López-Otín, J. Reynolds, G. Murphy (1998)
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.The Biochemical journal, 331 ( Pt 2)
V. Knäuper, H. Will, C. López-Otín, Bryan Smith, S. Atkinson, H. Stanton, R. Hembry, G. Murphy (1996)
Cellular Mechanisms for Human Procollagenase-3 (MMP-13) ActivationThe Journal of Biological Chemistry, 271
T. Rajavashisth, Xiao-ping Xu, S. Jovinge, S. Meisel, Xiao-Ou Xu, N. Chai, M. Fishbein, S. Kaul, B. Cercek, B. Sharifi, P. Shah (1999)
Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators.Circulation, 99 24
C. Overall, J. Sodek (1990)
Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.The Journal of biological chemistry, 265 34
S. Ishigaki, M. Toi, T. Ueno, H. Matsumoto, M. Muta, M. Koike, M. Seiki (1999)
Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast CancerJapanese Journal of Cancer Research : Gann, 90
R. Bai, X. Pei, O. Boyé, Z. Getahun, S. Grover, J. Bekisz, N. Nguyen, A. Brossi, E. Hamel (1996)
Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine (*)The Journal of Biological Chemistry, 271
C. Gilles, M. Polette, J. Piette, C. Munaut, Erik Thompson, P. Birembaut, J. Foidart (1996)
High level of MT‐MMP expression is associated with invasiveness of cervical cancer cellsInternational Journal of Cancer, 65
H. Foda, S. George, Cathleen Conner, M. Drews, Tompkins Dc, Stanley Zucker (1996)
Activation of human umbilical vein endothelial cell progelatinase A by phorbol myristate acetate: a protein kinase C-dependent mechanism involving a membrane-type matrix metalloproteinase.Laboratory investigation; a journal of technical methods and pathology, 74 2
T. Haas, D. Stitelman, S. Davis, S. Apte, J. Madri (1999)
Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*The Journal of Biological Chemistry, 274
K. Ota, W. Stetler-Stevenson, Q. Yang, A. Kumar, J. Wada, N. Kashihara, E. Wallner, Y. Kanwar (1998)
Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor.Kidney international, 54 1
B. Davies, D. Miles, L. Happerfield, M. Naylor, L. Bobrow, R. Rubens, F. Balkwill (1993)
Activity of type IV collagenases in benign and malignant breast disease.British Journal of Cancer, 67
P. Brown, D. Kleiner, E. Unsworth, W. Stetler-Stevenson (1993)
Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex.Kidney international, 43 1
M. Chenard, Y. Lutz, A. Méchine‐Neuville, I. Stoll, J. Bellocq, M. Rio, P. Basset (1999)
Presence of high levels of MT1‐MMP protein in fibroblastic cells of human invasive carcinomasInternational Journal of Cancer, 82
W. Monsky, T. Kelly, Chen-Yong Lin, Y. Yeh, W. Stetler-Stevenson, S. Mueller, Wen Chen (1993)
Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.Cancer research, 53 13
K. Imai, E. Ohuchi, T. Aoki, Hidehiro Nomura, Yutaka Fujii, Hiroshi Sato, M. Seiki, Yasunori Okada (1996)
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.Cancer research, 56 12
Saliha Afzal, E. Lalani, R. Poulsom, A. Stubbs, Gail Rowlinson, Hiroshi Sato, M. Seiki, G. Stamp (1998)
MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts.Human pathology, 29 2
Tiebang Kang, J. Yi, Wangrong Yang, Xing Wang, Aixiang Jiang, D. Pei (2000)
Functional characterization of MT3‐MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3‐D collagen latticeThe FASEB Journal, 14
Yuanping Han, T. Tuan, Huayang Wu, M. Hughes, W. Garner (2001)
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.Journal of cell science, 114 Pt 1
D. Pei, S. Weiss (1995)
Furin-dependent intracellular activation of the human stromelysin-3 zymogenNature, 375
(1996)
Birembaut I? MT-MMP expression and localisation in human lung and breast cancers
T. Kinoshita, Hiroshi Sato, A. Okada, E. Ohuchi, K. Imai, Y. Okada, M. Seiki (1998)
TIMP-2 Promotes Activation of Progelatinase A by Membrane-type 1 Matrix Metalloproteinase Immobilized on Agarose Beads*The Journal of Biological Chemistry, 273
G. Murphy, F. Willenbrock, R. Ward, M. Cockett, D. Eaton, A. Docherty (1992)
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases.The Biochemical journal, 283 ( Pt 3)
Y. Tsunezuka, H. Kinoh, T. Takino, Yoh Watanabe, Y. Okada, A. Shinagawa, Hiroshi Sato, M. Seiki (1996)
Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.Cancer research, 56 24
Shun-ichiro Matsumoto, Masao Katoh, S. Saito, Teruo Watanabe, Yasuhiko Masuho (1997)
Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA.Biochimica et biophysica acta, 1354 2
A. Yu, R. Hewitt, D. Kleiner, W. Stetler-Stevenson (1996)
Molecular regulation of cellular invasion--role of gelatinase A and TIMP-2.Biochemistry and cell biology = Biochimie et biologie cellulaire, 74 6
© 1999 Cancer Research Campaign Article no. bjoc.1998.0291
Masaaki Yamamoto, S. Mohanam, Raymond Sawaya, Gregory Fuller, Motoharu Seiki, Hiroshi Sato, Z. Gokaslan, Lance Liotta, Garth Nicolson, Jasti Rao (1996)
Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.Cancer research, 56 2
Sat 0 H , Murakami S ,
S. Kojima, Y. Itoh, S. Matsumoto, Y. Masuho, M. Seiki (2000)
Membrane‐type 6 matrix metalloproteinase (MT6‐MMP, MMP‐25) is the second glycosyl‐phosphatidyl inositol (GPI)‐anchored MMPFEBS Letters, 480
Hala Azzam, Erik Thompson (1992)
Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.Cancer research, 52 16
G. Giannelli, J. Falk-Marzillier, O. Schiraldi, W. Stetler-Stevenson, V. Quaranta (1997)
Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5.Science, 277 5323
V. Knäuper, C. López-Otín, Bryan Smith, G. Knight, G. Murphy (1996)
Biochemical Characterization of Human Collagenase-3 (*)The Journal of Biological Chemistry, 271
X. Puente, A. Pendás, E. Llano, G. Velasco, C. López-Otín (1996)
Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.Cancer research, 56 5
K. Heppner, L. Matrisian, Roy Jensen, William Rodgerst (1996)
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.The American journal of pathology, 149 1
L. Mccawley, L. Matrisian (2000)
Matrix metalloproteinases: multifunctional contributors to tumor progression.Molecular medicine today, 6 4
G. Butler, H. Will, S. Atkinson, G. Murphy (1997)
Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases.European journal of biochemistry, 244 2
A. Fosang, K. Last, Yutaka Fujii, M. Seiki, Y. Okada (1998)
Membrane‐type 1 MMP (MMP‐14) cleaves at three sites in the aggrecan interglobular domainFEBS Letters, 430
S. Ellerbroek, David Fishman, A. Kearns, Bafetti Lm, M. Stack (1999)
Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.Cancer research, 59 7
Xing Wang, J. Yi, Jianxun Lei, D. Pei (1999)
Expression, purification and charaterization of recombinant mouse MT5‐MMP protein productsFEBS Letters, 462
Yashuhide Kitagawa, K. Kunimi, H. Ito, Hiroshi Sato, T. Uchibayashi, Y. Okada, M. Seiki, M. Namiki (1998)
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.The Journal of urology, 160 4
Will (1995)
cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segmentEur J Biochem, 231
M. Nakada, Hiroyuki Nakamura, E. Ikeda, N. Fujimoto, Junkoh Yamashita, Hiroshi Sato, M. Seiki, Y. Okada (1999)
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors.The American journal of pathology, 154 2
D. Pei (1999)
Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineageCell Research, 9
M. Tóth, M. Bernardo, D. Gervasi, P. Soloway, Zhiping Wang, H. Bigg, Christopher Overall, Yves DeClerck, H. Tschesche, M. Cher, Stephen Brown, S. Mobashery, R. Fridman (2000)
Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2*The Journal of Biological Chemistry, 275
M. Mori, K. Mimori, T. Shiraishi, T. Fujie, K. Baba, Hiroki Kusumoto, M. Haraguchi, H. Ueo, T. Akiyoshi (1997)
Analysis of MT1‐MMP and MMP2 expression in human gastric cancersInternational Journal of Cancer, 74
E. Maquoi, F. Frankenne, E. Baramova, C. Munaut, N. Sounni, A. Remacle, A. Noël, G. Murphy, J. Foidart (2000)
Membrane Type 1 Matrix Metalloproteinase-associated Degradation of Tissue Inhibitor of Metalloproteinase 2 in Human Tumor Cell Lines*The Journal of Biological Chemistry, 275
K. Holmbeck, P. Bianco, J. Caterina, S. Yamada, Mark Kromer, S. Kuznetsov, M. Mankani, P. Robey, A. Poole, I. Pidoux, J. Ward, H. Birkedal‐Hansen (1999)
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen TurnoverCell, 99
Masaaki Tanaka, Hiroshi Sato, T. Takino, K. Iwata, M. Inoue, M. Seiki (1997)
Isolation of a mouse MT2‐MMP gene from a lung cDNA library and identification of its productFEBS Letters, 402
D. Gervasi, Avraham Raz, Marie Dehem, Maozhou Yang, Markku Kurkinen, R. Fridman (1996)
Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells.Biochemical and biophysical research communications, 228 2
W. English, X. Puente, J. Freije, V. Knäuper, A. Amour, Ann Merryweather, C. López-Otín, G. Murphy (2000)
Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2*The Journal of Biological Chemistry, 275
T. Takino, Hiroshi Sato, A. Shinagawa, M. Seiki (1995)
Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA LibraryThe Journal of Biological Chemistry, 270
C. Fernández-Catalán, W. Bode, R. Huber, D. Turk, J. Calvete, A. Lichte, H. Tschesche, K. Maskos (1998)
Crystal structure of the complex formed by the membrane type 1‐matrix metalloproteinase with the tissue inhibitor of metalloproteinases‐2, the soluble progelatinase A receptorThe EMBO Journal, 17
Frank Büttner, Clare Hughes, Daniel Margerie, A. Lichte, Harald Tschesche, B. Caterson, Eckart Bartnik (1998)
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.The Biochemical journal, 333 ( Pt 1)
Duan Pei, S. Weiss (1996)
Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity (*)The Journal of Biological Chemistry, 271
Alessandra Bini, Dan Wu, Jamie Schnuer, Bohdan Kudryk (1999)
Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragments.Biochemistry, 38 42
H. Will, B. Hinzmann (1995)
cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment.European journal of biochemistry, 231 3
H. Nakahara, L. Howard, Erik Thompson, Hiroshi Sato, M. Seiki, Y. Yeh, Wen‐Tien Chen (1997)
Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion.Proceedings of the National Academy of Sciences of the United States of America, 94 15
E. Ohuchi, K. Imai, Y. Fujii, Hiroshi Sato, M. Seiki, Y. Okada (1997)
Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules*The Journal of Biological Chemistry, 272
Masahiro Hosaka, Masami Nagahama, Won Kim, Tsuyoshi Watanabe, K. Hatsuzawa, J. Ikemizu, Kazuo Murakami, Kazuhisa Nakayama (1991)
Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.The Journal of biological chemistry, 266 19
Takashi Sato, Takayuki Kondo, M. Seiki, A. Ito (1999)
Cell Type‐Specific Involvement of Furin in Membrane Type 1 Matrix Metalloproteinase‐Mediated Progelatinase A ActivationAnnals of the New York Academy of Sciences, 878
A. Okada, J. Bellocq, N. Rouyer, M. Chenard, M. Rio, P. Chambon, P. Basset (1995)
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.Proceedings of the National Academy of Sciences of the United States of America, 92
Harada (1998)
Membrane-type matrix metalloproteinase-1 (MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomasJ Hepatol, 28
Matrix metalloproteinases (MMP) degrade components of extracellular matrix (ECM), and thereby regulate formation, remodeling and maintenance of tissue. Abnormal function of cell surface proteases associated with malignant tumors may contribute directly to the invasive and malignant nature of the cells. Among the MMP's associated with the tumor cell surface, gelatinase A is believed to be particularly important, since it degrades type IV collagen, and is activated in a tumor specific manner, correlating with tumor spread and poor prognosis. Activation of pro‐gelatinase A is uniquely regulated by a cell‐mediated mechanism. This study describes an in vitro model that mimics the cell‐surface activation mechanism. The expression of MT‐MMP could not be detected in normal epithelial cells, but can be seen in transformed epithelial carcinoma cells.
Apmis – Wiley
Published: Mar 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.