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Suppressive action of melatonin on the TH‐2 immune response in rats infected with Trypanosoma cruzi

Suppressive action of melatonin on the TH‐2 immune response in rats infected with Trypanosoma cruzi Abstract: Control of the acute phase of Trypanosoma cruzi infection is critically dependent on cytokine‐mediated macrophage activation to intracellular killing, natural killer (NK) cells, CD4+ T cells, CD8+ T cells and B cells. Cell‐mediated immunity in T. cruzi infection is also modulated by cytokines, but in addition to parasite‐specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell‐mediated immunity of infected subjects. Here we studied the role of cytokines in the regulation of innate and adaptive immunity during the acute phase of T. cruzi infection in Wistar rats. Melatonin is an effective regulator of the immune system. Macrophages and T lymphocytes, which have melatonin receptors, are target cells for the immunomodulatory function of melatonin. In this paper melatonin was orally given via two protocols: prior to and concomitant with infection. Both treatments were highly effective against T. cruzi with enhanced action for the concomitant treatment. The data suggest an up‐regulation of the TH‐1 immune response as all analyzed parameters, interleukin (IL)‐4, IL‐10, transforming growth factor‐β1 and splenocyte proliferation, displayed reduced levels as compared with the untreated counterparts. However, the direct effects of melatonin on immune cells have not been fully investigated during T. cruzi infection. We conclude that in light of the current results, melatonin exerted important therapeutic benefits through its immune regulatory effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pineal Research Wiley

Suppressive action of melatonin on the TH‐2 immune response in rats infected with Trypanosoma cruzi

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References (69)

Publisher
Wiley
Copyright
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
ISSN
0742-3098
eISSN
1600-079X
DOI
10.1111/j.1600-079X.2008.00589.x
pmid
18373553
Publisher site
See Article on Publisher Site

Abstract

Abstract: Control of the acute phase of Trypanosoma cruzi infection is critically dependent on cytokine‐mediated macrophage activation to intracellular killing, natural killer (NK) cells, CD4+ T cells, CD8+ T cells and B cells. Cell‐mediated immunity in T. cruzi infection is also modulated by cytokines, but in addition to parasite‐specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell‐mediated immunity of infected subjects. Here we studied the role of cytokines in the regulation of innate and adaptive immunity during the acute phase of T. cruzi infection in Wistar rats. Melatonin is an effective regulator of the immune system. Macrophages and T lymphocytes, which have melatonin receptors, are target cells for the immunomodulatory function of melatonin. In this paper melatonin was orally given via two protocols: prior to and concomitant with infection. Both treatments were highly effective against T. cruzi with enhanced action for the concomitant treatment. The data suggest an up‐regulation of the TH‐1 immune response as all analyzed parameters, interleukin (IL)‐4, IL‐10, transforming growth factor‐β1 and splenocyte proliferation, displayed reduced levels as compared with the untreated counterparts. However, the direct effects of melatonin on immune cells have not been fully investigated during T. cruzi infection. We conclude that in light of the current results, melatonin exerted important therapeutic benefits through its immune regulatory effects.

Journal

Journal of Pineal Research – Wiley

Published: Oct 1, 2008

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