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The effect of diffusional barriers upon the pharmacology of cells within the central nervous system

The effect of diffusional barriers upon the pharmacology of cells within the central nervous system J. Physiol. (I958) I41, 446-463 THE EFFECT OF DIFFUSIONAL BARRIERS UPON THE PHARMACOLOGY OF CELLS WITHIN THE CENTRAL NERVOUS SYSTEM BY D. R. CURTIS AND ROSAMOND M. ECCLES From the Department of Physiology, Australian National University, Canberra (Received December 1957) For many years it has been realized that the presence of the 'blood-brain barrier' has hindered the access of systematically administered drugs to possible central sites of action. The finding that Renshaw cells within the spinal cord are sensitive to acetylcholine and related substances, has provided a unique situation for the testing of drugs having known actions at peripheral cholinergic junctional regions. However, it seems likely that these cells are protected from some circulating drugs by at least two diffusional barriers. For example, the action of the blood-brain barrier is indicated by the finding that prostigmine is a very effective anticholinesterase when injected locally, but is almost ineffective when given intravenously (Eccles, Eccles & Fatt, 1956; D. R. Curtis, unpublished observation). The existence of a second barrier (cf. Eccles, Fatt & Koketsu, 1954; Curtis & Eccles, 1958), more intimately related to the synaptic terminals upon Renshaw is cells, suggested not a only by the duration of the repetitive discharge http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

The effect of diffusional barriers upon the pharmacology of cells within the central nervous system

Curtis, D. R.; Eccles, Rosamond M.
The Journal of Physiology , Volume 141 (3) – Jan 28, 1958
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References (31)

Publisher
Wiley
Copyright
© 2014 The Physiological Society
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1113/jphysiol.1958.sp005988
Publisher site
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Abstract

J. Physiol. (I958) I41, 446-463 THE EFFECT OF DIFFUSIONAL BARRIERS UPON THE PHARMACOLOGY OF CELLS WITHIN THE CENTRAL NERVOUS SYSTEM BY D. R. CURTIS AND ROSAMOND M. ECCLES From the Department of Physiology, Australian National University, Canberra (Received December 1957) For many years it has been realized that the presence of the 'blood-brain barrier' has hindered the access of systematically administered drugs to possible central sites of action. The finding that Renshaw cells within the spinal cord are sensitive to acetylcholine and related substances, has provided a unique situation for the testing of drugs having known actions at peripheral cholinergic junctional regions. However, it seems likely that these cells are protected from some circulating drugs by at least two diffusional barriers. For example, the action of the blood-brain barrier is indicated by the finding that prostigmine is a very effective anticholinesterase when injected locally, but is almost ineffective when given intravenously (Eccles, Eccles & Fatt, 1956; D. R. Curtis, unpublished observation). The existence of a second barrier (cf. Eccles, Fatt & Koketsu, 1954; Curtis & Eccles, 1958), more intimately related to the synaptic terminals upon Renshaw is cells, suggested not a only by the duration of the repetitive discharge

Journal

The Journal of Physiology – Wiley

Published: Jan 28, 1958

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