Richard Williams (2011)
Faculty Opinions recommendation of HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.
G. Semenza (2009)
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Physiology, 24
S. Sakaguchi, Tomoyuki Yamaguchi, T. Nomura, M. Ono (2008)
Regulatory T Cells and Immune ToleranceCell, 133
Yan Zheng, Greg Delgoffe, C. Meyer, Waipan Chan, J. Powell (2009)
Anergic T Cells Are Metabolically Anergic1The Journal of Immunology, 183
P. Shears (1991)
Epidemiology and infection in famine and disastersEpidemiology and Infection, 107
C. Cutler, J. Antin (2010)
Sirolimus immunosuppression for graft-versus-host disease prophylaxis and therapy: an updateCurrent Opinion in Hematology, 17
C. Dang (2010)
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.Cancer research, 70 3
G. Matarese, A. Cava (2004)
The intricate interface between immune system and metabolism.Trends in immunology, 25 4
M. Ostroukhova, N. Goplen, M. Karim, L. Michalec, Lei Guo, Q. Liang, R. Alam (2012)
The role of low-level lactate production in airway inflammation in asthma.American journal of physiology. Lung cellular and molecular physiology, 302 3
J. Powell, Cara Lerner, R. Schwartz (1999)
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.Journal of immunology, 162 5
N. Brown, M. Stefanovic‐Racic, I. Sipula, Germán Perdomo (2007)
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.Metabolism: clinical and experimental, 56 11
N. Alves, I. Derks, E. Berk, R. Spijker, R. Lier, E. Eldering (2006)
The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.Immunity, 24 6
C. Fox, P. Hammerman, C. Thompson (2005)
Fuel feeds function: energy metabolism and the T-cell responseNature Reviews Immunology, 5
K. Inoki, Tianqing Zhu, K. Guan (2003)
TSC2 Mediates Cellular Energy Response to Control Cell Growth and SurvivalCell, 115
E. Dang, J. Barbi, Huang-Yu Yang, Dilini Jinasena, Hong-gang Yu, Ying Zheng, Zachary Bordman, Juan Fu, Y. Kim, Hung-Rong Yen, W. Luo, K. Zeller, L. Shimoda, S. Topalian, G. Semenza, C. Dang, D. Pardoll, F. Pan (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1Cell, 146
N. Blatt, Anthony Boitano, C. Lyssiotis, A. Opipari, G. Glick (2008)
Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax.Free radical biology & medicine, 45 9
C. Cham, T. Gajewski (2005)
Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells1The Journal of Immunology, 174
S. Jacobs, Catherine Herman, Nancie MacIver, J. Wofford, Heather Wieman, J. Hammen, J. Rathmell (2008)
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1The Journal of Immunology, 180
A. Agrawal, U. Mabalirajan, T. Ahmad, B. Ghosh (2011)
Emerging interface between metabolic syndrome and asthma.American journal of respiratory cell and molecular biology, 44 3
Delgado (2008)
Obesity and asthmaJ. Investig. Allergol. Clin. Immunol., 18
M. Battaglia, A. Stabilini, M. Roncarolo (2005)
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Blood, 105 12
I. Sipula, N. Brown, Germán Perdomo (2006)
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation.Metabolism: clinical and experimental, 55 12
M. Heiden (2011)
Targeting cancer metabolism: a therapeutic window opensNature Reviews Drug Discovery, 10
D. Young, C. Nickerson-Nutter (2005)
mTOR--beyond transplantation.Current opinion in pharmacology, 5 4
Gergely (2002)
Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosusJ. Immunol., 169
Paul Pullmann, Andras Phillips, Peter Perl, Brian Gergely, Nick Niland, Rudolf Gonchoroff
Patients with Systemic Lupus Erythematosus Characterize Altered Il-10 Signaling in Production, and Cytoplasmic Alkalinization Increased Reactive Oxygen Intermediate Persistent Mitochondrial Hyperpolarization
Jonathan Coloff, Emily Mason, B. Altman, V. Gerriets, Tingyu Liu, Amanda Nichols, Yuxing Zhao, J. Wofford, S. Jacobs, O. Ilkayeva, Sean Garrison, G. Zambetti, J. Rathmell (2010)
Akt Requires Glucose Metabolism to Suppress Puma Expression and Prevent Apoptosis of Leukemic T Cells*The Journal of Biological Chemistry, 286
M. Mihaylova, R. Shaw (2011)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolismNature Cell Biology, 13
Erika Pearce, M. Walsh, P. Cejas, G. Harms, Hao Shen, Li-San Wang, Russell Jones, Yongwon Choi (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolismNature, 460
Ryan Michalek, V. Gerriets, S. Jacobs, A. Macintyre, Nancie MacIver, Emily Mason, S. Sullivan, Amanda Nichols, J. Rathmell (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell SubsetsThe Journal of Immunology, 186
P. Gergely, C. Grossman, Brian Niland, F. Puskas, H. Neupane, Fatme Allam, K. Bánki, P. Phillips, A. Perl (2002)
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus.Arthritis and rheumatism, 46 1
Russell Jones, C. Thompson (2007)
Revving the engine: signal transduction fuels T cell activation.Immunity, 27 2
J. Villena, A. Kralli (2008)
ERRα: a metabolic function for the oldest orphanTrends in Endocrinology & Metabolism, 19
L. Shi, Ruoning Wang, Gonghua Huang, P. Vogel, G. Neale, D. Green, H. Chi (2011)
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cellsThe Journal of Experimental Medicine, 208
K. Düvel, J. Yecies, Suchithra Menon, P. Raman, A. Lipovsky, Amanda Souza, E. Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, M. Heiden, J. MacKeigan, P. Finan, C. Clish, Leon Murphy, B. Manning (2010)
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.Molecular cell, 39 2
(2007)
glucose metabolism. Immunity
Ching-Yi Chang, Dmitri Kazmin, Jeff Jasper, R. Kunder, W. Zuercher, D. McDonnell (2011)
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.Cancer cell, 20 4
C. Dang, Jung-whan Kim, P. Gao, J. Yustein (2008)
The interplay between MYC and HIF in cancerNature Reviews Cancer, 8
Koppenol (2011)
Otto Warburg's contributions to current concepts of cancer metabolismNat. Rev. Cancer, 11
Ruoning Wang, C. Dillon, L. Shi, S. Milasta, R. Carter, D. Finkelstein, L. McCormick, Patrick Fitzgerald, H. Chi, Joshua Munger, D. Green (2011)
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.Immunity, 35 6
M. Heiden, L. Cantley, C. Thompson (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell ProliferationScience, 324
M. Gregor, G. Hotamışlıgil (2011)
Inflammatory mechanisms in obesity.Annual review of immunology, 29
F. Annunziato, S. Romagnani (2009)
Heterogeneity of human effector CD4+ T cellsArthritis Research & Therapy, 11
H. Saito, K. Nomura, M. Hotta, K. Takano (2007)
Malnutrition induces dissociated changes in lymphocyte count and subset proportion in patients with anorexia nervosa.The International journal of eating disorders, 40 6
O. Warburg (1956)
[Origin of cancer cells].Oncologia, 9 2
Nancie MacIver, S. Jacobs, Heather Wieman, J. Wofford, Jonathan Coloff, J. Rathmell (2008)
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survivalJournal of Leukocyte Biology, 84
K. Araki, A. Turner, V. Shaffer, Shivaprakash Gangappa, Susanne Keller, M. Bachmann, C. Larsen, R. Ahmed (2009)
mTOR regulates memory CD8 T cell differentiationNature, 460
M. Juntilla, J. Wofford, M. Birnbaum, J. Rathmell, G. Koretzky (2007)
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.Proceedings of the National Academy of Sciences of the United States of America, 104 29
D. Wahl, B. Petersen, R. Warner, B. Richardson, G. Glick, AW Opipari (2010)
Characterization of the metabolic phenotype of chronically activated lymphocytesLupus, 19
E. Gatza, D. Wahl, A. Opipari, Thomas Sundberg, P. Reddy, Chen Liu, G. Glick, J. Ferrara (2011)
Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host DiseaseScience Translational Medicine, 3
S. Haxhinasto, D. Mathis, C. Benoist (2008)
The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsThe Journal of Experimental Medicine, 205
S. Iyer, Janel Chatraw, W. Tan, E. Wherry, Todd Becker, R. Ahmed, Z. Kapasi (2012)
Protein Energy Malnutrition Impairs Homeostatic Proliferation of Memory CD8 T CellsThe Journal of Immunology, 188
M. Juntilla, J. Wofford, M. Birnbaum, J. Rathmell, G. Koretzky (2007)
Akt1 and Akt2 are required for αβ thymocyte survival and differentiationProceedings of the National Academy of Sciences, 104
F. Dunstan, Z. Guildea, K. Kontos, Alison Kemp, J. Sibert (2002)
A scoring system for bruise patterns: a tool for identifying abuseArchives of Disease in Childhood, 86
L. Bian, E. Josefsson, I. Jonsson, M. Verdrengh, C. Ohlsson, M. Bokarewa, A. Tarkowski, M. Magnusson (2009)
Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 miceArthritis Research & Therapy, 11
G. Windt, B. Everts, Chih-Hao Chang, Jonathan Curtis, T. Freitas, Eyal Amiel, E. Pearce, Erika Pearce (2012)
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.Immunity, 36 1
J. Powell, Kristen Pollizzi, Emily Heikamp, M. Horton (2012)
Regulation of immune responses by mTOR.Annual review of immunology, 30
Louise D’Cruz, M. Rubinstein, A. Goldrath (2009)
Surviving the crash: transitioning from effector to memory CD8+ T cell.Seminars in immunology, 21 2
Greg Delgoffe, T. Kole, Yan Zheng, Paul Zarek, Krystal Matthews, B. Xiao, P. Worley, S. Kozma, J. Powell (2009)
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.Immunity, 30 6
Ryan Michalek, V. Gerriets, Amanda Nichols, M. Inoue, Dmitri Kazmin, Ching-Yi Chang, M. Dwyer, E. Nelson, Kristen Pollizzi, O. Ilkayeva, V. Giguère, W. Zuercher, J. Powell, M. Shinohara, D. McDonnell, J. Rathmell (2011)
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiationProceedings of the National Academy of Sciences, 108
K. Frauwirth, J. Riley, M. Harris, R. Parry, J. Rathmell, D. Plas, R. Elstrom, C. June, C. Thompson (2002)
The CD28 signaling pathway regulates glucose metabolism.Immunity, 16 6
M. Laplante, D. Sabatini (2009)
mTOR signaling at a glanceJournal of Cell Science, 122
J. Wofford, Heather Wieman, S. Jacobs, Yuxing Zhao, J. Rathmell (2008)
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.Blood, 111 4
Greg Delgoffe, Kristen Pollizzi, A. Waickman, Emily Heikamp, D. Meyers, M. Horton, B. Xiao, P. Worley, J. Powell (2011)
The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signalingNature immunology, 12
A. Macintyre, D. Finlay, G. Preston, Linda Sinclair, C. Waugh, Péter Tamás, C. Feijóo, K. Okkenhaug, D. Cantrell (2011)
Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell MetabolismImmunity, 34
W. Koppenol, P. Bounds, C. Dang (2011)
Otto Warburg's contributions to current concepts of cancer metabolismNature Reviews Cancer, 11
J. Hoffmann, J. Reichhart (2002)
Drosophila innate immunity: an evolutionary perspectiveNature Immunology, 3
Heather Wieman, J. Wofford, J. Rathmell (2007)
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.Molecular biology of the cell, 18 4
J. Rathmell, R. Elstrom, Ryan Cinalli, C. Thompson (2003)
Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphomaEuropean Journal of Immunology, 33
E. Greiner, M. Guppy, K. Brand (1994)
Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.The Journal of biological chemistry, 269 50
Trends in Immunology – Unpaywall
Published: Apr 1, 2012
Access the full text.
Sign up today, get DeepDyve free for 14 days.