Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma
The Journal of Immunology
– Mar 28, 2013
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References (73)
-
K. Sakuishi, L. Apetoh, Jenna Sullivan, B. Blazar, V. Kuchroo, A. Anderson (2010)
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunityThe Journal of Experimental Medicine, 207
-
R. Sutmuller, L. Duivenvoorde, A. Elsas, T. Schumacher, M. Wildenberg, J. Allison, R. Toes, R. Offringa, C. Melief (2001)
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte ResponsesThe Journal of Experimental Medicine, 194
-
J. Landsberg, J. Kohlmeyer, Marcel Renn, T. Bald, Meri Rogava, Mira Cron, Martina Fatho, V. Lennerz, T. Wölfel, M. Hölzel, T. Tüting (2012)
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiationNature, 490
-
S. Quezada, K. Peggs, T. Simpson, Yuelei Shen, D. Littman, J. Allison (2008)
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanomaThe Journal of Experimental Medicine, 205
-
S. Josefowicz, A. Rudensky (2009)
Control of regulatory T cell lineage commitment and maintenance.Immunity, 30 5
-
H. Radziewicz, R. Dunham, A. Grakoui (2009)
PD-1 tempers Tregs in chronic HCV infection.The Journal of clinical investigation, 119 3
-
J. Fourcade, Zhaojun Sun, M. Benallaoua, P. Guillaume, I. Luescher, C. Sander, J. Kirkwood, V. Kuchroo, H. Zarour (2010)
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsThe Journal of Experimental Medicine, 207
-
Deborah Brown, Cris Kamperschroer, Allison Dilzer, Deborah Roberts, S. Swain (2009)
IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells.Cellular immunology, 257 1-2
-
Qing Zhou, Meghan Munger, Rachelle Veenstra, B. Weigel, M. Hirashima, D. Munn, W. Murphy, M. Azuma, A. Anderson, V. Kuchroo, B. Blazar (2011)
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.Blood, 117 17
-
G. Belz, A. Kallies (2010)
Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination.Current opinion in immunology, 22 3
-
P. Antony, C. Paulos, M. Ahmadzadeh, A. Akpinarli, D. Palmer, N. Sato, A. Kaiser, C. Hinrichs, C. Klebanoff, Y. Tagaya, N. Restifo (2006)
Interleukin-2-dependent mechanisms of tolerance and immunity in vivoThe Journal of Immunology, 176
-
P. Klenerman (2012)
Faculty Opinions recommendation of Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. -
Daniel Barber, E. Wherry, D. Masopust, Baogong Zhu, James Allison, Arlene Sharpe, Gordon Freeman, R. Ahmed (2006)
Restoring function in exhausted CD8 T cells during chronic viral infectionNature, 439
-
A. Grakoui, E. Wherry, H. Hanson, C. Walker, R. Ahmed (2006)
Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway.Journal of hepatology, 45 4
-
Xin Yu, Kristin Harden, Lino Gonzalez, M. Francesco, E. Chiang, B. Irving, I. Tom, S. Ivelja, C. Refino, H. Clark, D. Eaton, J. Grogan (2009)
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cellsNature Immunology, 10
-
S. Topalian, C. Drake, D. Pardoll (2012)
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.Current opinion in immunology, 24 2
-
H. Braumüller, T. Wieder, E. Brenner, Sonja Assmann, M. Hahn, M. Alkhaled, K. Schilbach, F. Essmann, M. Kneilling, C. Griessinger, Felicia Ranta, S. Ullrich, R. Mocikat, Kilian Braungart, T. Mehra, B. Fehrenbacher, Julia Berdel, H. Niessner, F. Meier, M. Broek, H. Häring, R. Handgretinger, L. Quintanilla‐Martinez, F. Fend, M. Pesic, J. Bauer, L. Zender, M. Schaller, K. Schulze-Osthoff, M. Röcken (2013)
T-helper-1-cell cytokines drive cancer into senescenceNature, 494
-
T. Lund (2008)
Faculty Opinions recommendation of Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. -
Antony (2006)
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.J. Immunol., 176
-
Zhi-Chun Ding, B. Blazar, A. Mellor, D. Munn, Gang Zhou (2010)
Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype.Blood, 115 12
-
Seng-Ryong Woo, Meghan Turnis, Monica Goldberg, Jaishree Bankoti, M. Selby, C. Nirschl, M. Bettini, D. Gravano, P. Vogel, C. Liu, Stephanie Tangsombatvisit, J. Grosso, G. Netto, M. Smeltzer, A. Chaux, P. Utz, C. Workman, D. Pardoll, A. Korman, C. Drake, D. Vignali
Microenvironment and Immunology Immune Inhibitory Molecules Lag-3 and Pd-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape -
Liang (2008)
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.J. Immunol., 180
-
W. Overwijk, David Lee, D. Surman, K. Irvine, C. Touloukian, Chi-Chao Chan, Miles Carroll, Bernard Moss, Steven Rosenberg, N. Restifo (1999)
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America, 96 6
-
Zhi-Chun Ding, Lei Huang, B. Blazar, H. Yagita, A. Mellor, D. Munn, Gang Zhou (2012)
Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy.Blood, 120 11
-
S. Quezada, T. Simpson, K. Peggs, T. Merghoub, J. Vider, Xiaozhou Fan, R. Blasberg, H. Yagita, P. Muranski, P. Antony, N. Restifo, J. Allison (2010)
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hostsThe Journal of Experimental Medicine, 207
-
Debora Franceschini, M. Paroli, V. Francavilla, M. Videtta, S. Morrone, G. Labbadia, A. Cerino, M. Mondelli, V. Barnaba (2009)
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.The Journal of clinical investigation, 119 3
-
Ying Xie, A. Akpinarli, C. Maris, Edward Hipkiss, M. Lane, Eun-Kyung Kwon, P. Muranski, N. Restifo, P. Antony (2010)
Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanomaThe Journal of Experimental Medicine, 207
-
Dorian Winter, J. Moser, E. Kriehuber, C. Wiesner, R. Knobler, F. Trautinger, Paula Bombosi, G. Stingl, P. Petzelbauer, A. Rot, D. Maurer (2007)
Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients1The Journal of Immunology, 179
-
P. Muranski, Zachary Borman, Sid Kerkar, C. Klebanoff, Yun Ji, L. Sanchez-Perez, M. Sukumar, R. Reger, Zhiya Yu, Steven Kern, R. Roychoudhuri, G. Ferreyra, W. Shen, S. Durum, L. Feigenbaum, D. Palmer, P. Antony, C. Chan, A. Laurence, R. Danner, L. Gattinoni, N. Restifo (2011)
Th17 cells are long lived and retain a stem cell-like molecular signature.Immunity, 35 6
-
Woo (2012)
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.Cancer Res., 72
-
J. Taube, R. Anders, Geoffrey Young, Haiying Xu, Rajni Sharma, T. McMiller, Shuming Chen, A. Klein, D. Pardoll, S. Topalian, Lieping Chen (2012)
Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune EscapeScience Translational Medicine, 4
-
Qing Zhou, Meghan Munger, S. Highfill, J. Tolar, B. Weigel, M. Riddle, A. Sharpe, D. Vallera, M. Azuma, B. Levine, C. June, W. Murphy, D. Munn, B. Blazar (2010)
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.Blood, 116 14
-
H. Jin, A. Anderson, W. Tan, E. West, S. Ha, K. Araki, G. Freeman, V. Kuchroo, R. Ahmed (2010)
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infectionProceedings of the National Academy of Sciences, 107
-
Dong (2002)
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.Nat. Med., 8
-
J. Groom, J. Richmond, T. Murooka, Elizabeth Sorensen, Jung Sung, Katherine Bankert, U. Andrian, J. Moon, T. Mempel, A. Luster (2012)
CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation.Immunity, 37 6
-
J. Scholler, Troy Brady, G. Binder-Scholl, W. Hwang, G. Plesa, K. Hege, Ashley Vogel, M. Kalos, J. Riley, S. Deeks, R. Mitsuyasu, W. Bernstein, N. Aronson, B. Levine, F. Bushman, C. June (2012)
Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T CellsScience Translational Medicine, 4
-
A. Rech, R. Mick, Sunil Martin, A. Recio, N. Aqui, D. Powell, T. Colligon, Jennifer Trosko, L. Leinbach, C. Pletcher, Carol Tweed, A. DeMichele, K. Fox, S. Domchek, J. Riley, R. Vonderheide (2012)
CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer PatientsScience Translational Medicine, 4
-
Ching-Tai Huang, C. Workman, D. Flies, Xiaoyu Pan, A. Marson, Gang Zhou, Edward Hipkiss, S. Ravi, J. Kowalski, H. Levitsky, J. Powell, D. Pardoll, C. Drake, D. Vignali (2004)
Role of LAG-3 in regulatory T cells.Immunity, 21 4
-
W. Zou (2005)
Immunosuppressive networks in the tumour environment and their therapeutic relevanceNature Reviews Cancer, 5
-
G. Freeman, E. Wherry, R. Ahmed, A. Sharpe (2006)
Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockadeThe Journal of Experimental Medicine, 203
-
P. Muranski, N. Restifo (2009)
Adoptive immunotherapy of cancer using CD4(+) T cells.Current opinion in immunology, 21 2
-
W. Zou (2006)
Regulatory T cells, tumour immunity and immunotherapyNature Reviews Immunology, 6
-
N. Liddy, G. Bossi, K. Adams, A. Lissina, T. Mahon, N. Hassan, J. Gavarret, F. Bianchi, N. Pumphrey, K. Ladell, E. Gostick, A. Sewell, N. Lissin, Naomi Harwood, P. Molloy, Yi Li, Brian Cameron, Malkit Sami, Emma Baston, P. Todorov, S. Paston, Rebecca Dennis, Jane Harper, S. Dunn, R. Ashfield, Andrew Johnson, Y. McGrath, G. Plesa, C. June, M. Kalos, D. Price, A. Vuidepot, Daniel Williams, Deborah Sutton, B. Jakobsen (2012)
Monoclonal TCR-redirected tumor cell killingNature Medicine, 18
-
Loise Francisco, Victor Salinas, Keturah Brown, V. Vanguri, G. Freeman, V. Kuchroo, A. Sharpe (2009)
PD-L1 regulates the development, maintenance, and function of induced regulatory T cellsThe Journal of Experimental Medicine, 206
-
J. Kim, J. Rasmussen, A. Rudensky (2007)
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceNature Immunology, 8
-
M. Curran, Welby Montalvo, H. Yagita, J. Allison (2010)
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumorsProceedings of the National Academy of Sciences, 107
-
Deborah Brown (2010)
Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy.Cellular immunology, 262 2
-
B. Barnett, Ilona Kryczek, P. Cheng, W. Zou, T. Curiel (2005)
Regulatory T Cells in Ovarian Cancer: Biology and Therapeutic PotentialAmerican Journal of Reproductive Immunology, 54
-
J. Grosso, Cristin Kelleher, T. Harris, C. Maris, Edward Hipkiss, A. Marzo, R. Anders, G. Netto, D. Getnet, T. Bruno, Monica Goldberg, D. Pardoll, C. Drake (2007)
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.The Journal of clinical investigation, 117 11
-
E. Lipson, W. Sharfman, C. Drake, I. Wollner, J. Taube, R. Anders, Haiying Xu, Sheng Yao, A. Pons, Lieping Chen, D. Pardoll, J. Brahmer, S. Topalian (2012)
Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 AntibodyClinical Cancer Research, 19
-
S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, David Smith, David McDermott, J. Powderly, Richard Carvajal, J. Sosman, M. Atkins, P. Leming, D. Spigel, S. Antonia, L. Horn, Charles Drake, D. Pardoll, Lieping Chen, W. Sharfman, Robert Anders, J. Taube, T. McMiller, Haiying Xu, A. Korman, M. Jure-Kunkel, S. Agrawal, D. McDonald, G. Kollia, A. Gupta, J. Wigginton, M. Sznol (2012)
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.The New England journal of medicine, 366 26
-
T. Curiel, G. Coukos, L. Zou, Xavier Alvarez, P. Cheng, P. Mottram, Melina Evdemon-Hogan, J. Conejo-Garcia, Lin Zhang, M. Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, B. Daniel, Alan Gordon, L. Myers, A. Lackner, M. Disis, K. Knutson, Lieping Chen, W. Zou (2004)
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalNature Medicine, 10
-
Xinrong Ma, Kelly Norsworthy, N. Kundu, W. Rodgers, P. Gimotty, O. Goloubeva, M. Lipsky, Yanchun Li, D. Holt, A. Fulton (2009)
CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine modelMolecular Cancer Therapeutics, 8
-
R. Purwar, C. Schlapbach, S. Xiao, H. Kang, W. Elyaman, Xiaodong Jiang, A. Jetten, S. Khoury, R. Fuhlbrigge, V. Kuchroo, R. Clark, T. Kupper (2012)
Robust tumor immunity to melanoma mediated by interleukin 9Nature medicine, 18
-
Shawn Blackburn, Haina Shin, W. Haining, Tao Zou, C. Workman, Antonio Polley, Michael Betts, Gordon Freeman, D. Vignali, E. Wherry (2009)
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infectionNature Immunology, 10
-
D. Hirschhorn-Cymerman, S. Budhu, S. Kitano, Cailian Liu, F. Zhao, H. Zhong, A. Lesokhin, Francesca Avogadri-Connors, Jianda Yuan, Yanyun Li, A. Houghton, T. Merghoub, J. Wolchok (2012)
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotypeThe Journal of Experimental Medicine, 209
-
Wangko Lundström, Natasha Fewkes, C. Mackall (2012)
IL-7 in human health and disease.Seminars in immunology, 24 3
-
C. Day, D. Kaufmann, P. Kiepiela, Julia Brown, Eshia Moodley, S. Reddy, Elizabeth Mackey, Joseph Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. Walker, B. Walker, B. Walker (2006)
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionNature, 443
-
S. Jensen, C. Twitty, L. Maston, P. Antony, May Lim, Hong-Ming Hu, U. Petrausch, N. Restifo, B. Fox (2012)
Increased Frequency of Suppressive Regulatory T Cells and T Cell-Mediated Antigen Loss Results in Murine Melanoma RecurrenceThe Journal of Immunology, 189
-
Shoba Amarnath, Courtney Mangus, J. Wang, Fang Wei, A. He, V. Kapoor, J. Foley, P. Massey, T. Felizardo, J. Riley, B. Levine, C. June, J. Medin, D. Fowler (2011)
The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T CellsScience Translational Medicine, 3
-
J. Brahmer, C. Drake, I. Wollner, J. Powderly, J. Picus, W. Sharfman, E. Stankevich, A. Pons, Theresa Salay, T. McMiller, Marta Gilson, Changyu Wang, M. Selby, J. Taube, R. Anders, Lieping Chen, A. Korman, D. Pardoll, I. Lowy, S. Topalian (2010)
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28 19
-
C. June, S. Rosenberg, M. Sadelain, J. Weber (2012)
T-cell therapy at the thresholdNature Biotechnology, 30
-
Natalia Martín‐Orozco, P. Muranski, Yeonseok Chung, Xuexian Yang, Tomohide Yamazaki, Sijie Lu, P. Hwu, N. Restifo, W. Overwijk, C. Dong (2009)
T helper 17 cells promote cytotoxic T cell activation in tumor immunity.Immunity, 31 5
-
P. Muranski, Andrea Boni, P. Antony, L. Cassard, K. Irvine, A. Kaiser, C. Paulos, D. Palmer, C. Touloukian, Krzysztof Ptak, L. Gattinoni, Claudia Wrzesinski, C. Hinrichs, Keith Kerstann, L. Feigenbaum, C. Chan, N. Restifo (2008)
Tumor-specific Th17-polarized cells eradicate large established melanoma.Blood, 112 2
-
M. Turk, J. Guevara-Patiño, G. Rizzuto, M. Engelhorn, A. Houghton (2004)
Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T CellsThe Journal of Experimental Medicine, 200
-
S. Strome, Haidong Dong, H. Tamura, Stephen Voss, D. Flies, K. Tamada, D. Salomão, J. Cheville, F. Hirano, Wei Lin, J. Kasperbauer, K. Ballman, Lieping Chen (2003)
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.Cancer research, 63 19
-
Haidong Dong, S. Strome, D. Salomão, H. Tamura, F. Hirano, D. Flies, P. Roche, Jun Lu, G. Zhu, K. Tamada, V. Lennon, E. Celis, Lieping Chen (2002)
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasionNature Medicine, 8
-
A. Fulton (2009)
The chemokine receptors CXCR4 and CXCR3 in cancerCurrent Oncology Reports, 11
-
A. Perez-Diez, N. Joncker, Kyungho Choi, W. Chan, C. Anderson, O. Lantz, P. Matzinger (2005)
CD4 cells can be more efficient at tumor rejection than CD8 cells.Blood, 109 12
-
P. Antony, C. Piccirillo, A. Akpinarli, S. Finkelstein, P. Speiss, D. Surman, D. Palmer, C. Chan, C. Klebanoff, W. Overwijk, S. Rosenberg, N. Restifo (2005)
CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory CellsThe Journal of Immunology, 174
-
Butler (2012)
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.Nat. Immunol., 13
-
Nicole Joller, J. Hafler, B. Brynedal, N. Kassam, S. Spoerl, S. Levin, A. Sharpe, V. Kuchroo (2011)
Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory FunctionsThe Journal of Immunology, 186
-
Zuqiang Liu, Jin Kim, L. Falo, Z. You (2009)
Tumor Regulatory T Cells Potently Abrogate Antitumor Immunity1The Journal of Immunology, 182
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Published: Mar 28, 2013