Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/expanded-polyglutamine-stretches-interact-with-tafii130-interfering-EIwvvLIODi
References (48)
-
A. Bonni, A. Brunet, A. West, S. Datta, M. Takasu, M. Greenberg (1999)
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.Science, 286 5443
-
Osamu Onodera, James Burke, Sara Miller, Susan Hester, Shoji Tsuji, A. Roses, Warren Strittmatter (1997)
Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells.Biochemical and biophysical research communications, 238 2
-
M. Usdin, M. Usdin, P. Shelbourne, R. Myers, D. Madison, D. Madison (1999)
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation.Human molecular genetics, 8 5
-
Mei Li, S. Miwa, Yasushi Kobayashi, D. Merry, Masahiko Yamamoto, F. Tanaka, M. Doyu, Yoshio Hashizum, K. Fischbeck, G. Sobue (1998)
Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophyAnnals of Neurology, 44
-
A. Sato, T. Shimohata, R. Koide, H. Takano, Toshiya Sato, M. Oyake, S. Igarashi, Keiko Tanaka, T. Inuzuka, H. Nawa, S. Tsuji (1999)
Adenovirus-mediated expression of mutant DRPLA proteins with expanded polyglutamine stretches in neuronally differentiated PC12 cells. Preferential intranuclear aggregate formation and apoptosis.Human molecular genetics, 8 6
-
Paul Brindle, S. Linke, M. Montminy (1993)
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressersNature, 364
-
A. Kazantsev, E. Preisinger, A. Dranovsky, D. Goldgaber, D. Housman (1999)
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America, 96 20
-
P. Skinner, B. Koshy, C. Cummings, I. Klement, K. Helin, A. Servadio, H. Zoghbi, H. Orr (1997)
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structuresNature, 389
-
Gabriele Schilling, J. Wood, K. Duan, H. Slunt, V. Gonzales, M. Yamada, J. Cooper, R. Margolis, N. Jenkins, N. Copeland, H. Takahashi, S. Tsuji, D. Price, D. Borchelt, C. Ross (1999)
Nuclear Accumulation of Truncated Atrophin-1 Fragments in a Transgenic Mouse Model of DRPLANeuron, 24
-
H. Paulson, Matthew Perez, Y. Trottier, J. Trojanowski, S. Subramony, S. Das, P. Vig, J. Mandel, K. Fischbeck, R. Pittman (1997)
Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3Neuron, 19
-
S. Davies, M. Turmaine, Barbara Cozens, M. Difiglia, A. Sharp, C. Ross, E. Scherzinger, E. Wanker, L. Mangiarini, G. Bates (1997)
Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD MutationCell, 90
-
Toshihiro Nakajima, C. Uchida, S. Anderson, Jeffrey Parvin, M. Montminy (1997)
Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.Genes & development, 11 6
-
D. Newmeyer, D. Forbes (1988)
Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocationCell, 52
-
I. Klement, P. Skinner, M. Kaytor, H. Yi, S. Hersch, H. Clark, H. Zoghbi, H. Orr (1998)
Ataxin-1 Nuclear Localization and Aggregation Role in Polyglutamine-Induced Disease in SCA1 Transgenic MiceCell, 95
-
M. Kalchman, H. Koide, K. McCutcheon, R. Graham, K. Nichol, K. Nishiyama, P. Kazemi-Esfarjani, F. Lynn, C. Wellington, M. Metzler, Y. Goldberg, I. Kanazawa, R. Gietz, M. Hayden (1997)
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brainNature Genetics, 16
-
Xiao-Jiang Li, Shihua Li, A. Sharp, F. Nucifora, Gabriele Schilling, A. Lanahan, P. Worley, S. Snyder, C. Ross (1995)
A huntingtin-associated protein enriched in brain with implications for pathologyNature, 378
-
A. Riccio, Sohyun Ahn, C. Davenport, J. Blendy, D. Ginty (1999)
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.Science, 286 5448
-
K. Moulder, O. Onodera, J. Burke, W. Strittmatter, E. Johnson (1999)
Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine LengthThe Journal of Neuroscience, 19
-
Shihua Li, A. Cheng, He Li, Xiao-Jiang Li (1999)
Cellular Defects and Altered Gene Expression in PC12 Cells Stably Expressing Mutant HuntingtinThe Journal of Neuroscience, 19
-
S. Igarashi, R. Koide, T. Shimohata, M. Yamada, Y. Hayashi, H. Takano, H. Date, M. Oyake, Toshiya Sato, A. Sato, S. Egawa, T. Ikeuchi, Hajime Tanaka, R. Nakano, Keiko Tanaka, I. Hozumi, T. Inuzuka, H. Takahashi, S. Tsuji (1998)
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretchNature Genetics, 18
-
M. Waragai, C. Lammers, S. Takeuchi, I. Imafuku, Y. Udagawa, I. Kanazawa, M. Kawabata, M. Mouradian, H. Okazawa (1999)
PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.Human molecular genetics, 8 6
-
O. Zhuchenko, J. Bailey, P. Bonnen, T. Ashizawa, D. Stockton, C. Amos, W. Dobyns, S. Subramony, H. Zoghbi, Cheng Lee (1997)
Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channelNature Genetics, 15
-
M. Difiglia, E. Sapp, K. Chase, S. Davies, G. Bates, J. Vonsattel, N. Aronin (1997)
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.Science, 277 5334
-
E. Sapp, P. Ge, H. Aizawa, E. Bird, J. Penney, A. Young, J. Vonsattel, M. Difiglia (1995)
Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysisNeuroscience, 64
-
H. Timmers, D. Swaab, J. Nes, H. Kremer (1996)
Somatostatin 1–12 immunoreactivity is decreased in the hypothalamic lateral tuberal nucleus of Huntington's disease patientsBrain Research, 728
-
D. Tait, M. Riccio, A. Sittler, E. Scherzinger, S. Santi, A. Ognibene, N. Maraldi, H. Lehrach, E. Wanker (1998)
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.Human molecular genetics, 7 6
-
Seiichi Mizushima, S. Nagata (1990)
pEF-BOS, a powerful mammalian expression vector.Nucleic acids research, 18 17
-
D. Parker, K. Ferreri, Toshihiro Nakajima, V. Lamorte, R. Evans, S. Koerber, C. Hoeger, M. Montminy (1996)
Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanismMolecular and Cellular Biology, 16
-
S. Sisodia (1998)
Nuclear Inclusions in Glutamine Repeat Disorders Are They Pernicious, Coincidental, or Beneficial?Cell, 95
-
H. Ikeda, M. Yamaguchi, S. Sugai, Y. Aze, S. Narumiya, A. Kakizuka (1996)
Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivoNature Genetics, 13
-
S. Koyano, T. Uchihara, H. Fujigasaki, A. Nakamura, S. Yagishita, K. Iwabuchi (1999)
Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent studyNeuroscience Letters, 273
-
H. Gerber, K. Seipel, O. Georgiev, M. Hofferer, M. Hug, S. Rusconi, W. Schaffner (1994)
Transcriptional activation modulated by homopolymeric glutamine and proline stretches.Science, 263 5148
-
N. Tanese, D. Saluja, M. Vassallo, J. Chen, A. Admon (1996)
Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100.Proceedings of the National Academy of Sciences of the United States of America, 93 24
-
E. Souza, P. Whitehouse, S. Folstein, D. Price, W. Vale (1987)
Corticotropin-releasing hormone (CRH) is decreased in the basal ganglia in Huntington's diseaseBrain Research, 437
-
M. Kaytor, L. Duvick, P. Skinner, M. Koob, L. Ranum, H. Orr (1999)
Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7.Human molecular genetics, 8 9
-
RH Schiestl, RD Gietz (1989)
High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrierCurr. Genet., 16
-
C. Ross (1997)
Intranuclear Neuronal Inclusions: A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases?Neuron, 19
-
A. Matilla, B. Koshy, C. Cummings, T. Isobe, H. Orr, H. Zoghbi (1997)
The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1Nature, 389
-
G. Gonzalez, M. Montminy (1989)
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Cell, 59
-
Matthew Perez, H. Paulson, Sagun Pendse, Sarah Saionz, N. Bonini, R. Pittman (1998)
Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated AggregationThe Journal of Cell Biology, 143
-
T. Miyashita, Kazuaki Nagao, K. Ohmi, H. Yanagisawa, Y. Okamura-Oho, M. Yamada (1998)
Intracellular aggregate formation of dentatorubral-pallidoluysian atrophy (DRPLA) protein with the extended polyglutamine.Biochemical and biophysical research communications, 249 1
-
M. Holmberg, C. Duyckaerts, A. Durr, G. Cancel, I. Gourfinkel‐An, P. Damier, B. Faucheux, Y. Trottier, E. Hirsch, Y. Agid, A. Brice (1998)
Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.Human molecular genetics, 7 5
-
F. Saudou, S. Finkbeiner, D. Devys, M. Greenberg (1998)
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear InclusionsCell, 95
-
G. Mengus, M. May, L. Carré, P. Chambon, I. Davidson (1997)
Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.Genes & development, 11 11
-
J. Dignam, R. Lebovitz, R. Roeder (1983)
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.Nucleic acids research, 11 5
-
L. Mangiarini, K. Sathasivam, M. Seller, Barbara Cozens, Alex Harper, C. Hetherington, Martin Lawton, Y. Trottier, H. Lehrach, S. Davies, G. Bates (1996)
Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic MiceCell, 87
-
J. Simental, Madhabananda Sar, Malcolm Lane, Frank French, E. Wilson (1991)
Transcriptional activation and nuclear targeting signals of the human androgen receptor.The Journal of biological chemistry, 266 1
-
Y. Goldberg, D. Nicholson, D. Rasper, M. Kalchman, H. Koide, R. Graham, M. Bromm, P. Kazemi-Esfarjani, N. Thornberry, J. Vaillancourt, M. Hayden (1996)
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tractNature Genetics, 13
- Publisher
- Springer Journals
- Copyright
- Copyright © 2000 by Nature America Inc.
- Subject
- Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- DOI
- 10.1038/79139
- Publisher site
- See Article on Publisher Site
Abstract
At least eight inherited neurodegenerative diseases are caused by expanded CAG repeats encoding polyglutamine (polyQ) stretches. Although cytotoxicities of expanded polyQ stretches are implicated, the molecular mechanisms of neurodegeneration remain unclear. We found that expanded polyQ stretches preferentially bind to TAFII130, a coactivator involved in cAMP-responsive element binding protein (CREB)-dependent transcriptional activation, and strongly suppress CREB-dependent transcriptional activation. The suppression of CREB-dependent transcription and the cell death induced by polyQ stretches were restored by the co-expression of TAFII130. Our results indicate that interference of transcription by the binding of TAFII130 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.
Journal
Nature Genetics – Springer Journals
Published: Sep 1, 2000