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Molecular basis of functional voltage‐gated K + channel diversity in the mammalian myocardium

Molecular basis of functional voltage‐gated K + channel diversity in the mammalian myocardium In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+) currents contribute importantly to shaping the waveforms of action potentials, and several distinct types of voltage‐gated K+ currents that subserve this role have been characterized. In most cardiac cells, transient outward currents, Ito,f and/or Ito,s, and several components of delayed reactivation, including IKr, IKs, IKur and IK,slow, are expressed. Nevertheless, there are species, as well as cell‐type and regional, differences in the expression patterns of these currents, and these differences are manifested as variations in action potential waveforms. A large number of voltage‐gated K+ channel pore‐forming (α) and accessory (β, minK, MiRP) subunits have been cloned from or shown to be expressed in heart, and a variety of experimental approaches are being exploited in vitro and in vivo to define the relationship(s) between these subunits and functional voltage‐gated cardiac K+ channels. Considerable progress has been made in defining these relationships recently, and it is now clear that distinct molecular entities underlie the various electrophysiologically distinct repolarizing K+ currents (i.e. Ito,f, Ito,s, IKr, IKs, IKur, IK,slow, etc.) in myocyardial cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Physiology Wiley

Molecular basis of functional voltage‐gated K + channel diversity in the mammalian myocardium

Nerbonne, Jeanne M.
The Journal of Physiology , Volume 525 (2) – Jun 1, 2000
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References (161)

Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3751
eISSN
1469-7793
DOI
10.1111/j.1469-7793.2000.t01-1-00285.x
Publisher site
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Abstract

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+) currents contribute importantly to shaping the waveforms of action potentials, and several distinct types of voltage‐gated K+ currents that subserve this role have been characterized. In most cardiac cells, transient outward currents, Ito,f and/or Ito,s, and several components of delayed reactivation, including IKr, IKs, IKur and IK,slow, are expressed. Nevertheless, there are species, as well as cell‐type and regional, differences in the expression patterns of these currents, and these differences are manifested as variations in action potential waveforms. A large number of voltage‐gated K+ channel pore‐forming (α) and accessory (β, minK, MiRP) subunits have been cloned from or shown to be expressed in heart, and a variety of experimental approaches are being exploited in vitro and in vivo to define the relationship(s) between these subunits and functional voltage‐gated cardiac K+ channels. Considerable progress has been made in defining these relationships recently, and it is now clear that distinct molecular entities underlie the various electrophysiologically distinct repolarizing K+ currents (i.e. Ito,f, Ito,s, IKr, IKs, IKur, IK,slow, etc.) in myocyardial cells.

Journal

The Journal of Physiology – Wiley

Published: Jun 1, 2000

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