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Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study

Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory... To evaluate factors predisposing to liver injury following jejunoileal bypass, 27 patients underwent clinical evaluation and liver biopsy prior to bypass and at 3, 6, 12, 18, and 24 months and yearly thereafter. Nineteen patients developed increased fatty infiltration of the liver, 1 developed cryptogenic cirrhosis, and 7 developed steatonecrosis, central hyaline sclerosis, or cirrhosis indistinguishable from alcoholic liver disease during the period of rapid weight loss. Two of these 7 patients developed clinical liver failure; inactive cirrhosis evolved after parenteral alimentation and reanastomosis in one, and after oral nutritional supplementation in the other. Four of 5 asymptomatic patients resolved to inactive cirrhosis as weight loss diminished. Each of the 7 patients had pericentral fibrosis on pre‐bypass liver biopsies, suggesting a previous hepatic injury. These patients were older (p < 0.02) and, 3 months following bypass, had greater cumulative per cent weight loss (p < 0.05), higher levels of serum aspartate aminotransferase (p < 0.005), and greater 45‐min bromosulfophthalein retention (p < 0.02). Histologic evidence of pericentral fibrosis identified patients at risk to develop steatonecrosis and cirrhosis; these lesions occurred in older patients who had greater weight loss following jejunoileal bypass. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology Wolters Kluwer Health

Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study

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Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study

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References (42)

Publisher
Wolters Kluwer Health
Copyright
Copyright © 1981 American Association for the Study of Liver Diseases
ISSN
0270-9139
eISSN
1527-3350
DOI
10.1002/hep.1840010212
Publisher site
See Article on Publisher Site

Abstract

To evaluate factors predisposing to liver injury following jejunoileal bypass, 27 patients underwent clinical evaluation and liver biopsy prior to bypass and at 3, 6, 12, 18, and 24 months and yearly thereafter. Nineteen patients developed increased fatty infiltration of the liver, 1 developed cryptogenic cirrhosis, and 7 developed steatonecrosis, central hyaline sclerosis, or cirrhosis indistinguishable from alcoholic liver disease during the period of rapid weight loss. Two of these 7 patients developed clinical liver failure; inactive cirrhosis evolved after parenteral alimentation and reanastomosis in one, and after oral nutritional supplementation in the other. Four of 5 asymptomatic patients resolved to inactive cirrhosis as weight loss diminished. Each of the 7 patients had pericentral fibrosis on pre‐bypass liver biopsies, suggesting a previous hepatic injury. These patients were older (p < 0.02) and, 3 months following bypass, had greater cumulative per cent weight loss (p < 0.05), higher levels of serum aspartate aminotransferase (p < 0.005), and greater 45‐min bromosulfophthalein retention (p < 0.02). Histologic evidence of pericentral fibrosis identified patients at risk to develop steatonecrosis and cirrhosis; these lesions occurred in older patients who had greater weight loss following jejunoileal bypass.

Journal

Hepatology – Wolters Kluwer Health

Published: Mar 1, 1981

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