Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/taylor-francis/gefs-in-growth-factor-signaling-Rpm9aY0Wq3
References (72)
-
H. Sondermann, S. Soisson, Sean Boykevisch, Shao-song Yang, D. Bar-Sagi, J. Kuriyan (2004)
Structural Analysis of Autoinhibition in the Ras Activator Son of SevenlessCell, 119
-
G. Scita, Johan Nordstrom, R. Carbone, P. Tenca, G. Giardina, S. Gutkind, Mattias Bjarnegård, C. Betsholtz, P. Fiore (1999)
EPS8 and E3B1 transduce signals from Ras to RacNature, 401
-
S. Corbalán-García, S. Margarit, D. Galron, Shao-song Yang, D. Bar-Sagi (1998)
Regulation of Sos Activity by Intramolecular InteractionsMolecular and Cellular Biology, 18
-
R. Kunita, A. Otomo, Hikaru Mizumura, K. Suzuki-Utsunomiya, S. Hadano, J. Ikeda (2007)
The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis*Journal of Biological Chemistry, 282
-
N. Gnesutta, M. Ceriani, M. Innocenti, I. Mauri, R. Zippel, E. Sturani, B. Borgonovo, G. Berruti, E. Martegani (2001)
Cloning and Characterization of Mouse UBPy, a Deubiquitinating Enzyme That Interacts with the Ras Guanine Nucleotide Exchange Factor CDC25Mm/Ras-GRF1*The Journal of Biological Chemistry, 276
-
J. Weissman, H. Plutner, W. Balch (2001)
The Mammalian Guanine Nucleotide Exchange Factor mSec12 is Essential for Activation of the Sar1 GTPase Directing Endoplasmic Reticulum ExportTraffic, 2
-
M. Hafner, A. Schmitz, Imke Grüne, S. Srivatsan, B. Paul, W. Kolanus, T. Quast, E. Kremmer, Inga Bauer, M. Famulok (2006)
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistanceNature, 444
-
A. Bernards (2006)
Ras superfamily and interacting proteins database.Methods in enzymology, 407
-
C. Dermardirossian, A. Schnelzer, G. Bokoch (2004)
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.Molecular cell, 15 1
-
C. Jackson, J. Casanova (2000)
Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors.Trends in cell biology, 10 2
-
B. Davies, J. Topp, Agnel Sfeir, D. Katzmann, Darren Carney, G. Tall, A. Friedberg, L. Deng, Zhijian Chen, B. Horazdovsky (2003)
Vps9p CUE Domain Ubiquitin Binding Is Required for Efficient Endocytic Protein Traffic*Journal of Biological Chemistry, 278
-
Yi Yang, A. Hentati, H. Deng, O. Dabbagh, T. Sasaki, M. Hirano, W. Hung, K. Ouahchi, Jianhua Yan, A. Azim, N. Cole, G. Gascon, A. Yagmour, M. Ben-Hamida, M. Pericak-Vance, F. Hentati, T. Siddique (2001)
Erratum: The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis (Nature Genetics (2001) 29 (160-165))Nature Genetics, 29
-
Bernward Hinkes, R. Wiggins, R. Gbadegesin, C. Vlangos, D. Seelow, G. Nürnberg, P. Garg, R. Verma, H. Chaib, Bethan Hoskins, S. Ashraf, C. Becker, H. Hennies, M. Goyal, B. Wharram, A. Schachter, S. Mudumana, I. Drummond, D. Kerjaschki, R. Waldherr, A. Dietrich, F. Ozaltin, A. Bakkaloğlu, R. Cleper, L. Basel‐Vanagaite, M. Pohl, M. Griebel, A. Tsygin, A. Soylu, D. Müller, Caroline Sorli, T. Bunney, M. Katan, Jinhong Liu, M. Attanasio, John O'Toole, K. Hasselbacher, Bettina Mucha, E. Otto, R. Airik, A. Kispert, G. Kelley, A. Smrcka, T. Gudermann, L. Holzman, P. Nürnberg, F. Hildebrandt (2006)
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversibleNature Genetics, 38
-
Mark Barber, S. Donald, S. Thelen, K. Anderson, M. Thelen, Heidi Welch (2007)
Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.The Journal of biological chemistry, 282 41
-
X. Su, C. Kong, P. Stahl (2007)
GAPex-5 Mediates Ubiquitination, Trafficking, and Degradation of Epidermal Growth Factor Receptor*Journal of Biological Chemistry, 282
-
E. Kamynina, K. Kauppinen, F. Duan, Nora Muakkassa, D. Manor (2006)
Regulation of Proto-Oncogenic Dbl by Chaperone-Controlled, Ubiquitin-Mediated DegradationMolecular and Cellular Biology, 27
-
(2007)
CFC and Noonan syndromes due to mutations in RAS/MAPK signaling pathway: Genotype/phenotype relationships and overlap with Costello syndrome -
M. Hayakawa, H. Kitagawa, K. Miyazawa, M. Kitagawa, K. Kikugawa (2005)
The FWD1/β‐TrCP‐mediated degradation pathway establishes a ‘turning off switch’ of a Cdc42 guanine nucleotide exchange factor, FGD1Genes to Cells, 10
-
Y. Aoki, T. Niihori, H. Kawame, K. Kurosawa, H. Ohashi, Yukichi Tanaka, M. Filocamo, Kumi Kato, Yoichi Suzuki, S. Kure, Y. Matsubara (2005)
Germline mutations in HRAS proto-oncogene cause Costello syndromeNature Genetics, 37
-
Y. Takai, K. Kaibuchi, A. Kikuchi, M. Kawata (1992)
Small GTP-binding proteins.International review of cytology, 133
-
A. Bernards, J. Settleman (2005)
GAPs in growth factor signallingGrowth Factors, 23
-
Yuko Miura-Shimura, Lei Duan, N. Rao, A. Reddi, H. Shimura, R. Rottapel, Brain Druker, A. Tsygankov, V. Band, H. Band (2003)
Cbl-mediated Ubiquitinylation and Negative Regulation of Vav*Journal of Biological Chemistry, 278
-
J. Bowzard, Dongmei Cheng, Junmin Peng, R. Kahn (2007)
ELMOD2 Is an Arl2 GTPase-activating Protein That Also Acts on Arfs*Journal of Biological Chemistry, 282
-
Suzanne Schubbert, M. Zenker, Sara Rowe, Silke Böll, C. Klein, G. Bollag, I. Burgt, L. Musante, V. Kalscheuer, L. Wehner, Hoa Nguyen, B. West, Kam Zhang, E. Sistermans, A. Rauch, C. Niemeyer, K. Shannon, C. Kratz (2006)
Germline KRAS mutations cause Noonan syndromeNature Genetics, 38
-
Chen Zhao, G. Du, K. Skowronek, M. Frohman, D. Bar-Sagi (2007)
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by SosNature Cell Biology, 9
-
J. Birkenfeld, P. Nalbant, B. Bohl, O. Pertz, K. Hahn, G. Bokoch (2007)
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.Developmental cell, 12 5
-
T. Hart, Yingze Zhang, M. Gorry, P. Hart, M. Cooper, M. Marazita, Jared Marks, J. Cortelli, D. Pallos (2002)
A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1.American journal of human genetics, 70 4
-
N. Pasteris, Amy Cadle, L. Logie, M. Porteous, C. Schwartz, R. Stevenson, T. Glover, R. Wilroy, J. Gorski (1994)
Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative Rho Rac guanine nucleotide exchange factorCell, 79
-
V. Yajnik, C. Paulding, Raffaella Sordella, A. McClatchey, Mako Saito, D. Wahrer, P. Reynolds, D. Bell, Robert Lake, S. Heuvel, J. Settleman, D. Haber (2003)
DOCK4, a GTPase Activator, Is Disrupted during TumorigenesisCell, 112
-
(2006)
Identification of TRIO-GEFD1 -
M. Petronczki, M. Glotzer, N. Kraut, J. Peters (2007)
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.Developmental cell, 12 5
-
D. Baird, Q. Feng, R. Cerione (2005)
The Cool-2/α-Pix Protein Mediates a Cdc42-Rac Signaling CascadeCurrent Biology, 15
-
Steven Waters, K. Yamauchi, J. Pessin (1995)
Insulin-stimulated disassociation of the SOS-Grb2 complexMolecular and Cellular Biology, 15
-
D. Baird, Q. Feng, R. Cerione (2005)
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.Current biology : CB, 15 1
-
L. Reiter, T. Seagroves, M. Bowers, E. Bier (2006)
Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase.Human molecular genetics, 15 18
-
P. Rodriguez-Viciana, O. Tetsu, W. Tidyman, A. Estep, Brenda Conger, M. Cruz, F. McCormick, K. Rauen (2006)
Germline Mutations in Genes Within the MAPK Pathway Cause Cardio-facio-cutaneous SyndromeScience, 311
-
A. Blangy, Nathalie Bouquier, C. Gauthier-Rouvière, S. Schmidt, A. Debant, J. Leonetti, P. Fort (2006)
Identification of TRIO‐GEFD1 chemical inhibitors using the yeast exchange assayBiology of the Cell, 98
-
Y. Hsu, J. Chern, Yi Cai, Mingyao Liu, Kwang-Wook Choi (2007)
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPaseNature, 445
-
Heidi Welch, W. Coadwell, C. Ellson, G. Ferguson, S. Andrews, H. Erdjument-Bromage, P. Tempst, P. Hawkins, L. Stephens (2002)
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.Cell, 108 6
-
(1994)
Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative Rho/Rac guanine nucleotide exchange factor, 79
-
V. Delague, A. Jacquier, T. Hamadouche, Y. Poitelon, Cécile Baudot, I. Boccaccio, E. Chouery, M. Chaouch, N. Kassouri, R. Jabbour, D. Grid, A. Mégarbané, G. Haase, Nicolas Lévy (2007)
G.O.3 Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4HNeuromuscular Disorders, 17
-
K. Kutsche, H. Yntema, Alexander Brandt, I. Jantke, H. Nothwang, U. Orth, M. Boavida, D. David, J. Chelly, J. Fryns, C. Moraine, H. Ropers, B. Hamel, H. Bokhoven, A. Gal (2000)
Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardationNature Genetics, 26
-
L. Penengo, M. Mapelli, A. Murachelli, S. Confalonieri, L. Magri, A. Musacchio, P. Fiore, Simona Polo, T. Schneider (2006)
Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with UbiquitinCell, 124
-
M. Razzaque, T. Nishizawa, Yuta Komoike, Hisato Yagi, M. Furutani, Ryunosuke Amo, M. Kamisago, K. Momma, H. Katayama, M. Nakagawa, Y. Fujiwara, M. Matsushima, K. Mizuno, M. Tokuyama, H. Hirota, J. Muneuchi, T. Higashinakagawa, R. Matsuoka (2007)
Germline gain-of-function mutations in RAF1 cause Noonan syndromeNature Genetics, 39
-
T. Niihori, Y. Aoki, Y. Narumi, G. Neri, H. Cavé, A. Verloes, N. Okamoto, R. Hennekam, G. Gillessen‐Kaesbach, D. Wieczorek, M. Kavamura, K. Kurosawa, H. Ohashi, L. Wilson, D. Heron, D. Bonneau, G. Corona, T. Kaname, K. Naritomi, C. Baumann, N. Matsumoto, Kumi Kato, S. Kure, Y. Matsubara (2006)
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndromeNature Genetics, 38
-
Kenji Takahashi, T. Kohno, R. Ajima, H. Sasaki, J. Minna, T. Fujiwara, N. Tanaka, J. Yokota (2006)
Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer.International journal of oncology, 28 2
-
S. Moeller, Elizabeth Head, R. Sheaff (2003)
p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras ActivationMolecular and Cellular Biology, 23
-
N. Pham, D. Rotin (2001)
Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF*The Journal of Biological Chemistry, 276
-
K. Ishikawa, S. Toru, T. Tsunemi, Mingshun Li, Kazuhiro Kobayashi, T. Yokota, T. Amino, K. Owada, H. Fujigasaki, Masaki Sakamoto, H. Tomimitsu, M. Takashima, J. Kumagai, Y. Noguchi, Yoshiyuki Kawashima, N. Ohkoshi, G. Ishida, M. Gomyoda, Mari Yoshida, Y. Hashizume, Yuko Saito, S. Murayama, H. Yamanouchi, T. Mizutani, I. Kondo, T. Toda, H. Mizusawa (2005)
An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains.American journal of human genetics, 77 2
-
(2007)
ARHGEF9 disruption -
K. Hahn, A. Toutchkine (2002)
Live-cell fluorescent biosensors for activated signaling proteins.Current opinion in cell biology, 14 2
-
J. Rooij, H. Rehmann, Miranda Triest, Robert Cool, A. Wittinghofer, J. Bos (2000)
Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs*The Journal of Biological Chemistry, 275
-
F. Niiya, T. Tatsumoto, K. Lee, T. Miki (2006)
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoAOncogene, 25
-
Yi Yang, A. Hentati, H. Deng, O. Dabbagh, Toru Sasaki, M. Hirano, W. Hung, K. Ouahchi, Jianhua Yan, A. Azim, N. Cole, G. Gascon, A. Yagmour, M. Ben-Hamida, M. Pericak-Vance, F. Hentati, T. Siddique (2001)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosisNature Genetics, 29
-
J. Bos, H. Rehmann, A. Wittinghofer (2007)
GEFs and GAPs: Critical Elements in the Control of Small G ProteinsCell, 129
-
M. Fernandez-Zapico, Natalia Gonzalez-Paz, Ellen Weiss, Doris Savoy, J. Molina, R. Fonseca, T. Smyrk, S. Chari, R. Urrutia, D. Billadeau (2005)
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis.Cancer cell, 7 1
-
A. Roberts, T. Araki, K. Swanson, K. Montgomery, T. Schiripo, V. Joshi, Li Li, Yosuf Yassin, Alex Tamburino, B. Neel, R. Kucherlapati (2007)
Germline gain-of-function mutations in SOS1 cause Noonan syndromeNature Genetics, 39
-
C. Nava, N. Hanna, C. Michot, S. Pereira, N. Pouvreau, T. Niihori, Y. Aoki, Y. Matsubara, B. Arveiler, D. Lacombe, E. Pasmant, B. Parfait, C. Baumann, D. Heron, S. Sigaudy, A. Toutain, M. Rio, A. Goldenberg, B. Leheup, A. Verloes, H. Cavé (2007)
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype–phenotype relationships and overlap with Costello syndromeJournal of Medical Genetics, 44
-
H. Bourne, D. Sanders, F. McCormick (1990)
The GTPase superfamily: a conserved switch for diverse cell functionsNature, 348
-
W. Wu, Shine Tu, R. Cerione (2003)
Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor DegradationCell, 114
-
Sangho Lee, Y. Tsai, R. Mattera, William Smith, M. Kostelansky, A. Weissman, J. Bonifacino, J. Hurley (2006)
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5Nature Structural &Molecular Biology, 13
-
V. Sheen, V. Ganesh, M. Topçu, G. Sébire, A. Bodell, R. Hill, P. Grant, Y. Shugart, J. Imitola, S. Khoury, R. Guerrini, Christopher Walsh (2004)
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortexNature Genetics, 36
-
B. Pandit, A. Sarkozy, L. Pennacchio, C. Carta, Kimihiko Oishi, S. Martinelli, E. Pogna, Wendy Schackwitz, Anna Ustaszewska, A. Landstrom, J. Bos, S. Ommen, Giorgia Esposito, F. Lepri, C. Faul, P. Mundel, J. Siguero, R. Tenconi, A. Selicorni, C. Rossi, L. Mazzanti, I. Torrente, B. Marino, M. Digilio, G. Zampino, M. Ackerman, B. Dallapiccola, M. Tartaglia, M. Tartaglia, B. Gelb (2007)
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathyNature Genetics, 39
-
(2006)
Structural basis for -
Sean Boykevisch, Chen Zhao, H. Sondermann, Polyxeni Philippidou, S. Halegoua, J. Kuriyan, D. Bar-Sagi (2006)
Regulation of Ras Signaling Dynamics by Sos-Mediated Positive FeedbackCurrent Biology, 16
-
J. Rosa, R. Casaroli-Marano, A. Buckler, S. Vilaró, M. Barbacid (1996)
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.The EMBO Journal, 15
-
J. Helms, J. Rothman (1992)
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARFNature, 360
-
Carmen Hoog, J. Koehler, M. Goldstein, Paul Taylor, D. Figeys, M. Moran (2001)
Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2Molecular and Cellular Biology, 21
-
E. Marco, F. Abidi, J. Bristow, Willow Dean, Philip Cotter, Rita Jeremy, C. Schwartz, E. Sherr (2007)
ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousalJournal of Medical Genetics, 45
-
Mark Barber, S. Donald, S. Thelen, K. Anderson, M. Thelen, Heidi Welch (2007)
Membrane Translocation of P-Rex1 Is Mediated by G Protein βγ Subunits and Phosphoinositide 3-Kinase*Journal of Biological Chemistry, 282
-
M. Tartaglia, L. Pennacchio, Chen Zhao, K. Yadav, V. Fodale, A. Sarkozy, B. Pandit, Kimihiko Oishi, S. Martinelli, Wendy Schackwitz, Anna Ustaszewska, Joel Martin, J. Bristow, C. Carta, F. Lepri, C. Neri, I. Vasta, K. Gibson, C. Curry, J. Siguero, M. Digilio, G. Zampino, B. Dallapiccola, D. Bar-Sagi, B. Gelb (2006)
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndromeNature Genetics, 39
-
M. Tartaglia, E. Mehler, R. Goldberg, G. Zampino, H. Brunner, H. Kremer, I. Burgt, A. Crosby, A. Ion, S. Jeffery, K. Kalidas, M. Patton, R. Kucherlapati, B. Gelb (2001)
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndromeNature Genetics, 29
- Publisher
- Taylor & Francis
- Copyright
- © 2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
- ISSN
- 1029-2292
- eISSN
- 0879-7194
- DOI
- 10.1080/08977190701830375
- pmid
- 18236214
- Publisher site
- See Article on Publisher Site
Abstract
Evolutionary conserved members of the Ras superfamily of small GTP-binding proteins function as binary molecular switches to control diverse biological processes. In the context of cellular signaling, these include functions in exocytic and endocytic trafficking, as well as roles in signal relay downstream of various cell surface receptors. We previously reviewed roles played by the large family of GTPase, activating proteins in these processes. In this companion review, we highlight recent findings relating to the regulation of another major class of Ras superfamily regulatory proteins, the guanine nucleotide exchange factors.
Journal
Growth Factors – Taylor & Francis
Published: Jan 1, 2007
Keywords: Growth factors; guanine nucleotide exchange factor; signal transduction; Ras superfamily; GTPase regulation