Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Sylvia Christakos; Puneet Dhawan; Annemieke Verstuyf; Lieve Verlinden; Geert Carmeliet

doi:10.1152/physrev.00014.2015

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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Christakos, Sylvia; Dhawan, Puneet; Verstuyf, Annemieke; Verlinden, Lieve; Carmeliet, Geert

Physiological Reviews – Dec 23, 2015

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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Christakos, Sylvia; Dhawan, Puneet; Verstuyf, Annemieke; Verlinden, Lieve; Carmeliet, Geert

Physiological Reviews – Dec 23, 2015

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References (548)

Jongha Park, Connie Rhee, W. Lau, K. Kalantar-Zadeh (2014)
Clinical uses of 1-alpha-hydroxy-ergocalciferol.
Current vascular pharmacology, 12 2
D. Bikle, J. Adams, S. Christakos (2013)
Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements
C. Wagner, N. Hernando, I. Forster, J. Biber (2013)
The SLC34 family of sodium-dependent phosphate transporters
Pflügers Archiv - European Journal of Physiology, 466
H. Henry, A. Norman (1978)
Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability.
Science, 201 4358
N. Harvey, C. Cooper (2012)
Vitamin D: some perspective please
BMJ : British Medical Journal, 345
T. Evans, K. Colston, F. Lofts, D. Cunningham, D. Anthoney, H. Gogas, J. bono, K. Hamberg, T. Skov, J. Mansi (2002)
A phase II trial of the vitamin D analogue Seocalcitol (EB1089) in patients with inoperable pancreatic cancer
British Journal of Cancer, 86
M. Chung, Jounghee Lee, T. Terasawa, J. Lau, T. Trikalinos (2011)
Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force
Annals of Internal Medicine, 155
G. Eelen, Noelia Valle, Yoshiteru Sato, N. Rochel, L. Verlinden, P. Clercq, D. Moras, R. Bouillon, A. Muñoz, A. Verstuyf (2008)
Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.
Chemistry & biology, 15 10
A. Nykjaer, J. Fyfe, R. Kozyraki, Jörg-Robert Leheste, C. Jacobsen, M. Nielsen, P. Verroust, M. Aminoff, A. Chapelle, S. Moestrup, R. Ray, J. Gliemann, T. Willnow, E. Christensen (2001)
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D3
Proceedings of the National Academy of Sciences of the United States of America, 98
S. Moe (2007)
Vitamin D, Cardiovascular Disease, and Survival in Dialysis Patients
Journal of Bone and Mineral Research, 22
A. Ross, J. Manson, S. Abrams, J. Aloia, J. Aloia, P. Brannon, S. Clinton, R. Durazo-Arvizu, J. Gallagher, R. Gallo, Glenville Jones, C. Kovacs, S. Mayne, C. Rosen, S. Shapses (2010)
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know
The Journal of Clinical Endocrinology and Metabolism, 96
G. Bises, E. Kallay, T. Weiland, F. Wrba, E. Wenzl, E. Bonner, S. Kriwanek, P. Obrist, H. Cross (2004)
25-Hydroxyvitamin D3-1α-hydroxylase Expression in Normal and Malignant Human Colon
Journal of Histochemistry & Cytochemistry, 52
I. Pickholtz, Shira Saadyan, G. Keshet, Victor Wang, Rachel Cohen, P. Bouwman, J. Jonkers, S. Byers, M. Papa, R. Yarden (2014)
Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells
Oncotarget, 5
R. St-Arnaud, Serge Messerlian, J. Moir, J. Omdahl, F. Glorieux (1997)
The 25‐Hydroxyvitamin D 1‐Alpha‐Hydroxylase Gene Maps to the Pseudovitamin D‐Deficiency Rickets (PDDR) Disease Locus
Journal of Bone and Mineral Research, 12
S. Morris, M. Tallquist, C. Rock, Jonathan Cooper (2002)
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport
The EMBO Journal, 21
A. Mondul, I. Shui, Kai Yu, S. Weinstein, K. Tsilidis, A. Joshi, A. Agudo, C. Berg, A. Black, J. Buring, D. Chasman, M. Gaudet, C. Haiman, S. Hankinson, B. Henderson, R. Hoover, D. Hunter, K. Khaw, T. Kühn, M. Kvaskoff, L. Marchand, S. Lindström, M. McCullough, K. Overvad, P. Peeters, E. Riboli, P. Ridker, D. Stram, M. Sund, D. Trichopoulos, R. Tumino, E. Weiderpass, W. Willett, P. Kraft, R. Ziegler, D. Albanes (2014)
Vitamin D–Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)
Cancer Epidemiology, Biomarkers & Prevention, 24
Scott Bauer, S. Hankinson, E. Bertone-Johnson, E. Ding (2013)
Plasma Vitamin D Levels, Menopause, and Risk of Breast Cancer
Medicine, 92
J. Marniemi, E. Alanen, O. Impivaara, R. Seppänen, P. Hakala, T. Rajala, T. Rönnemaa (2005)
Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 15 3
O. Golovko, N. Nazarova, P. Tuohimaa (2005)
Vitamin D–induced up–regulation of tumour necrosis factor alpha (TNF–α) in prostate cancer cells
Life Sciences, 77
K. Takeyama, S. Kitanaka, Takashi Sato, M. Kobori, J. Yanagisawa, S. Kato (1997)
25-Hydroxyvitamin D3 1α-Hydroxylase and Vitamin D Synthesis
Science, 277
K. Jarnagin, R. Brommage, H. DeLuca, S. Yamada, H. Takayama (1983)
1- but not 24-hydroxylation of vitamin D is required for growth and reproduction in rats.
The American journal of physiology, 244 3
T. Shimada, M. Kakitani, Y. Yamazaki, H. Hasegawa, Y. Takeuchi, T. Fujita, S. Fukumoto, K. Tomizuka, T. Yamashita (2004)
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.
The Journal of clinical investigation, 113 4
Ryan Forster, P. Jurutka, J. Hsieh, C. Haussler, Christine Lowmiller, I. Kaneko, M. Haussler, G. Whitfield (2011)
Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells.
Biochemical and biophysical research communications, 414 3
E. Gardiner, P. Baldock, Gethin Thomas, N. Sims, N. Henderson, Bruce Hollis, C. White, K. Sunn, N. Morrison, W. Walsh, J. Eisman (2000)
Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage
The FASEB Journal, 14
Kimberly Santucci, K. Snyder, J. Baust, R. Buskirk, V. Mouraviev, T. Polascik, A. Gage, J. Baust (2010)
The use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model
Prostate cancer and prostatic diseases, 14
S. Casella, B. Reiner, T. Chen, M. Holick, H. Harrison (1994)
A possible genetic defect in 25-hydroxylation as a cause of rickets.
The Journal of pediatrics, 124 6
N. Keum, E. Giovannucci (2014)
Vitamin D supplements and cancer incidence and mortality: a meta-analysis
British Journal of Cancer, 111
S. Ramagopalan, A. Heger, A. Berlanga, N. Maugeri, M. Lincoln, Amy Burrell, L. Handunnetthi, A. Handel, G. Disanto, S. Orton, C. Watson, J. Morahan, G. Giovannoni, C. Ponting, G. Ebers, J. Knight (2010)
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.
Genome research, 20 10
J. Zhang, Z. Yao (1999)
[The effect of 1, 25 (OH)(2)D(3)on growth and apoptosis in breast cancer cell line MCF-7].
Zhonghua wai ke za zhi [Chinese journal of surgery], 37 8
Jeffrey Cheng, D. Motola, D. Mangelsdorf, D. Russell (2003)
DE-ORPHANIZATION OF CYTOCHROME P450 2R1: A MICROSOMAL VITAMIN D 25-HYDROXYLASE
G. Eelen, L. Verlinden, M. Camp, F. Claessens, P. Clercq, M. Vandewalle, R. Bouillon, A. Verstuyf (2005)
Altered Vitamin D receptor–coactivator interactions reflect superagonism of Vitamin D analogs
The Journal of Steroid Biochemistry and Molecular Biology, 97
R. Chun (2012)
New perspectives on the vitamin D binding protein
Cell Biochemistry and Function, 30
Luz Tavera-Mendoza, Tian-tian Wang, B. Lallemant, Rui Zhang, Yoshihiko Nagai, V. Bourdeau, Mario Ramirez-Calderon, J. Desbarats, S. Mader, John White (2006)
Convergence of vitamin D and retinoic acid signalling at a common hormone response element
EMBO reports, 7
A. Webb, L. Kline, M. Holick (1988)
Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin.
The Journal of clinical endocrinology and metabolism, 67 2
N. Ditsch, B. Toth, D. Mayr, M. lenhard, J. Gallwas, T. Weissenbacher, C. Dannecker, K. Friese, U. Jeschke (2012)
The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer
Journal of Histochemistry & Cytochemistry, 60
H. DeLuca, W. Bedale, N. Binkley, J. Gallagher, M. Bolognese, M. Peacock, J. Aloia, M. Clagett-Dame, L. Plum (2011)
The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1‐year phase 2 double‐blind, placebo‐controlled, randomized clinical trial
Journal of Bone and Mineral Research, 26
Thomas Wang, Feng Zhang, J. Richards, B. Kestenbaum, J. Meurs, D. Berry, D. Kiel, E. Streeten, C. Ohlsson, Daniel Koller, L. Peltonen, J. Cooper, P. O’Reilly, D. Houston, N. Glazer, L. Vandenput, M. Peacock, J. Shi, F. Rivadeneira, M. McCarthy, Pouta Anneli, I. Boer, M. Mangino, B. Kato, D. Smyth, S. Booth, P. Jacques, G. Burke, M. Goodarzi, C. Cheung, M. Wolf, K. Rice, D. Goltzman, N. Hidiroglou, M. Ladouceur, N. Wareham, L. Hocking, D. Hart, N. Arden, C. Cooper, S. Malik, W. Fraser, A. Hartikainen, G. Zhai, H. Macdonald, N. Forouhi, R. Loos, D. Reid, A. Hakim, E. Dennison, Yongmei Liu, C. Power, H. Stevens, Laitinen Jaana, R. Vasan, N. Soranzo, J. Bojunga, B. Psaty, M. Lorentzon, T. Foroud, T. Harris, A. Hofman, J. Jansson, J. Cauley, A. Uitterlinden, Q. Gibson, M. Järvelin, D. Karasik, D. Siscovick, M. Econs, S. Kritchevsky, J. Florez, J. Todd, J. Dupuis, E. Hyppönen, T. Spector (2010)
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
The Lancet, 376
Yan Li, M. Amling, A. Pirro, M. Priemel, Jennifer Meuse, R. Baron, G. Delling, M. Demay (1998)
Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice.
Endocrinology, 139 10
G. Bjelakovic, L. Gluud, D. Nikolova, K. Whitfield, G. Krstić, J. Wetterslev, C. Gluud (2014)
Vitamin D supplementation for prevention of cancer in adults.
The Cochrane database of systematic reviews, 6
P. Ordóñez-Morán, M. Larriba, H. Pálmer, R. Valero, A. Barbáchano, M. Duñach, A. Herreros, C. Villalobos, M. Berciano, M. Lafarga, A. Muñoz (2008)
RhoA–ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells
The Journal of Cell Biology, 183
Peter Brøndum-Jacobsen, M. Benn, G. Jensen, B. Nordestgaard (2012)
25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death: Population-Based Study and Meta-Analyses of 18 and 17 Studies
Arteriosclerosis, Thrombosis, and Vascular Biology, 32
R. Prince, Nicole Austin, A. Devine, I. Dick, D. Bruce, K. Zhu (2008)
Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women.
Archives of internal medicine, 168 1
Yingyu Ma, Wei-dong Yu, B. Su, M. Seshadri, W. Luo, D. Trump, Candace Johnson (2013)
Regulation of motility, invasion, and metastatic potential of squamous cell carcinoma by 1α,25‐dihydroxycholecalciferol
Cancer, 119
(2013)
Vitamin D: production, metabolism and clinical requirements. In: Primer Metab Bone Dis, edited by Rosen C
Joseph Wahler, J. So, Larry Cheng, H. Maehr, M. Uskoković, N. Suh (2015)
Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer
The Journal of Steroid Biochemistry and Molecular Biology, 148
G. Ferreira, E. Etten, A. Verstuyf, M. Waer, L. Overbergh, C. Gysemans, C. Mathieu (2011)
1,25‐Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo
Diabetes/Metabolism Research and Reviews, 27
P. Dwivedi, J. Omdahl, I. Kola, D. Hume, B. May (2000)
Regulation of Rat Cytochrome P450C24 (CYP24) Gene Expression
The Journal of Biological Chemistry, 275
Weicheng Liu, Yunzi Chen, M. Golan, M. Annunziata, Jie Du, U. Dougherty, J. Kong, M. Musch, Yong Huang, J. Pekow, Changqing Zheng, M. Bissonnette, S. Hanauer, Y. Li (2013)
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
The Journal of clinical investigation, 123 9
Richard Lund, D. Andress, M. Amdahl, L. Williams, R. Heaney (2009)
Differential Effects of Paricalcitol and Calcitriol on Intestinal Calcium Absorption in Hemodialysis Patients
American Journal of Nephrology, 31
R. Bouillon, W. Okamura, A. Norman (1995)
Structure-function relationships in the vitamin D endocrine system.
Endocrine reviews, 16 2
Lee Zella, M. Meyer, R. Nerenz, S. Lee, Melissa Martowicz, J. Pike (2010)
Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.
Molecular endocrinology, 24 1
Antonio Berlanga-Taylor, J. Knight (2014)
An Integrated Approach to Defining Genetic and Environmental Determinants for Major Clinical Outcomes Involving Vitamin D
Molecular Diagnosis & Therapy, 18
E. Abe, C. Miyaura, H. Sakagami, M. Takeda, K. Konno, T. Yamazaki, S. Yoshiki, T. Suda (1981)
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America, 78 8
S. Gregori, Nadia Giarratana, S. Smiroldo, M. Uskoković, L. Adorini (2002)
A 1α,25-Dihydroxyvitamin D3 Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice
Diabetes, 51
J. Blaine, M. Chonchol, M. Levi (2015)
Renal control of calcium, phosphate, and magnesium homeostasis.
Clinical journal of the American Society of Nephrology : CJASN, 10 7
Glenville Jones, D. Prosser (2011)
The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases)
S. Khader, S. Gaffen, J. Kolls (2009)
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
Mucosal Immunology, 2
N. Liu, Amber Kaplan, V. Lagishetty, Yuxin Ouyang, Ouyang Yi, C. Simmons, O. Equils, M. Hewison (2011)
InflammationVitamin D and the Regulation of Placental
B. Schöttker, R. Jorde, A. Peasey, B. Thorand, E. Jansen, L. Groot, M. Streppel, Julian Gardiner, J. Ordóñez-Mena, L. Perna, T. Wilsgaard, W. Rathmann, E. Feskens, E. Kampman, Galatios Siganos, I. Njølstad, E. Mathiesen, R. Kubínová, A. Pająk, R. Topor-Madry, A. Tamošiūnas, M. Hughes, F. Kee, M. Bobák, A. Trichopoulou, P. Boffetta, H. Brenner (2014)
Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
The BMJ, 348
D. Bikle (2014)
Vitamin D metabolism, mechanism of action, and clinical applications.
Chemistry & biology, 21 3
Zhan Guo, Jianguo Wen, Q. Kan, Shuman Huang, Xianghua Liu, Ning Sun, Zhenzhen Li (2013)
Lack of association between vitamin D receptor gene FokI and BsmI polymorphisms and prostate cancer risk: an updated meta-analysis involving 21,756 subjects
Tumor Biology, 34
M. Sherman, R. Yu, Dannielle Engle, N. Ding, A. Atkins, H. Tiriac, E. Collisson, F. Connor, T. Dyke, S. Kozlov, Philip Martin, Tiffany Tseng, D. Dawson, T. Donahue, A. Masamune, T. Shimosegawa, M. Apte, Jeremy Wilson, B. Ng, S. Lau, J. Gunton, G. Wahl, T. Hunter, J. Drebin, P. O'dwyer, C. Liddle, D. Tuveson, M. Downes, R. Evans (2014)
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Cell, 159
Y. Sabbagh, T. Carpenter, M. Demay (2005)
Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes.
Proceedings of the National Academy of Sciences of the United States of America, 102 27
(2014)
1,25-Dihydroxyvitamin D3 CHRISTAKOS ET AL
J. Reichrath, S. Müller, A. Kerber, H. Baum, F. Bahmer (1997)
Biologic effects of topical calcipotriol (MC 903) treatment in psoriatic skin.
Journal of the American Academy of Dermatology, 36 1
D. Dowd, P. MacDonald (2011)
Coregulators of VDR-mediated gene expression
M. Milczarek, Sara Rosińska, Mateusz Psurski, M. Maciejewska, A. Kutner, J. Wietrzyk (2013)
Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin.
Anticancer research, 33 2
Mohamed Elamin, Nisrin Elnour, Khalid Elamin, M. Fatourechi, A. Alkatib, Jaime Almandoz, Hau Liu, Melanie Lane, R. Mullan, A. Hazem, P. Erwin, D. Hensrud, M. Murad, V. Montori (2011)
Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis.
The Journal of clinical endocrinology and metabolism, 96 7
K. Colston, M. Colston, D. Feldman (1981)
1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture.
Endocrinology, 108 3
Yoko Yamamoto, T. Yoshizawa, T. Fukuda, Yuko Shirode-Fukuda, T. Yu, K. Sekine, Takashi Sato, H. Kawano, K. Aihara, Yuko Nakamichi, Tomoyuki Watanabe, Masayo Shindo, Kazuki Inoue, Erina Inoue, Naoya Tsuji, Maiko Hoshino, G. Karsenty, D. Metzger, P. Chambon, S. Kato, Yuuki Imai (2013)
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
Endocrinology, 154 3
N. Nazarova, O. Golovko, M. Bläuer, P. Tuohimaa (2005)
Calcitriol inhibits growth response to Platelet-Derived Growth Factor-BB in human prostate cells
The Journal of Steroid Biochemistry and Molecular Biology, 94
S. Tamura, K. Ueki, Keiichi Mashimo, Y. Tsukada, M. Naitoh, Y. Abe, H. Kawai, A. Tsuchida, R. Wakamatsu, Y. Nojima (2005)
Comparison of the efficacy of an oral calcitriol pulse or intravenous 22-oxacalcitriol therapies in chronic hemodialysis patients
Clinical and Experimental Nephrology, 9
M. Cantorna, C. Hayes, H. DeLuca (1996)
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America, 93 15
R. Chun, Philip Liu, R. Modlin, J. Adams, M. Hewison (2014)
Impact of vitamin D on immune function: lessons learned from genome-wide analysis
Frontiers in Physiology, 5
H. Rebel, Celia Spek, D. Salvatori, J. Leeuwen, E. Robanus-Maandag, F. Gruijl (2015)
UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine‐specific Apc mutant mice kept on low vitamin D diet
International Journal of Cancer, 136
I. Alroy, Terri Towers, L. Freedman (1995)
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
Molecular and Cellular Biology, 15
A. Prentice (2013)
Nutritional rickets around the world
The Journal of Steroid Biochemistry and Molecular Biology, 136
A. Norman (2008)
From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.
The American journal of clinical nutrition, 88 2
T. Monkawa, T. Yoshida, S. Wakino, T. Shinki, H. Anazawa, H. DeLuca, T. Suda, M. Hayashi, T. Saruta (1997)
Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.
Biochemical and biophysical research communications, 239 2
S. Santagata, A. Thakkar, A. Ergonul, Bin Wang, Terri Woo, R. Hu, J. Harrell, G. McNamara, Matthew Schwede, A. Culhane, D. Kindelberger, S. Rodig, A. Richardson, S. Schnitt, R. Tamimi, T. Ince (2014)
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
The Journal of clinical investigation, 124 2
G. Bjelakovic, L. Gluud, D. Nikolova, K. Whitfield, J. Wetterslev, R. Simonetti, M. Bjelaković, C. Gluud (2014)
Vitamin D supplementation for prevention of mortality in adults.
The Cochrane database of systematic reviews, 1
W. Ni, S. Watts, Michael Ng, Songcang Chen, D. Glenn, D. Gardner (2014)
Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function
Hypertension, 64
S. Cromphaut, I. Stockmans, S. Torrekens, E. Herck, G. Carmeliet, R. Bouillon (2007)
Duodenal calcium absorption in dexamethasone-treated mice: functional and molecular aspects.
Archives of biochemistry and biophysics, 460 2
G. Penna, S. Amuchastegui, C. Cossetti, Francesca Aquilano, R. Mariani, F. Sanvito, C. Doglioni, L. Adorini (2006)
Treatment of Experimental Autoimmune Prostatitis in Nonobese Diabetic Mice by the Vitamin D Receptor Agonist Elocalcitol1
The Journal of Immunology, 177
Kim Köstner, Nicole Denzer, Cornelia Müller, R. Klein, W. Tilgen, J. Reichrath (2009)
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Anticancer research, 29 9
J. Frazão, L. Elangovan, H. Maung, R. Chesney, S. Acchiardo, J. Bower, B. Kelley, H. Rodriguez, Keith Norris, J. Robertson, B. Levine, W. Goodman, D. Gentile, R. Mazess, D. Kyllo, L. Douglass, C. Bishop, J. Coburn (2000)
Intermittent doxercalciferol (1alpha-hydroxyvitamin D(2)) therapy for secondary hyperparathyroidism.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 36 3
Kai Zhang, Lihua Song (2014)
Association between Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis of 39 Studies
PLoS ONE, 9
D. Matusiak, R. Benya (2007)
CYP27A1 and CYP24 Expression as a Function of Malignant Transformation in the Colon
Journal of Histochemistry & Cytochemistry, 55
Robert Wasserman (2004)
Vitamin D and the dual processes of intestinal calcium absorption.
The Journal of nutrition, 134 11
T. Oppé (1979)
Vitamin D deficiency.
British Medical Journal, 2
Lijuan Xu, X. Wan, Zhi-min Huang, Fangfang Zeng, G. Wei, D. Fang, W. Deng, Yanbing Li (2013)
Impact of Vitamin D on Chronic Kidney Diseases in Non-Dialysis Patients: A Meta-Analysis of Randomized Controlled Trials
PLoS ONE, 8
C. Ritter, Alex Brown (2011)
Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D‐binding protein and resistance to metabolism
Journal of Cellular Biochemistry, 112
T. Nakashima, M. Hayashi, T. Fukunaga, K. Kurata, M. Oh‐hora, Jian Feng, L. Bonewald, T. Kodama, A. Wutz, E. Wagner, J. Penninger, H. Takayanagi (2011)
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nature Medicine, 17
Whitney Hendrickson, R. Flavin, J. Kasperzyk, M. Fiorentino, Fang Fang, R. Lis, C. Fiore, K. Penney, Jing Ma, P. Kantoff, M. Stampfer, M. Loda, L. Mucci, E. Giovannucci (2011)
Vitamin D receptor protein expression in tumor tissue and prostate cancer progression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 17
M. Hughes, P. Malloy, D. Kieback, R. Kesterson, J. Pike, D. Feldman, B. O’Malley (1988)
Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets.
Science, 242 4886
Michaela Pfeifer, B. Begerow, Helmut Minne, D. Nachtigall, C. Hansen (2001)
Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.
The Journal of clinical endocrinology and metabolism, 86 4
L. Quarles (2012)
Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease.
Experimental cell research, 318 9
L. Quarles (2012)
Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
Nature Reviews Endocrinology, 8
Matthew Palmer, Y. Lee, Craig Maynard, J. Oliver, D. Bikle, A. Jetten, C. Weaver (2010)
Lineage-specific Effects of 1,25-Dihydroxyvitamin D3 on the Development of Effector CD4 T Cells*
The Journal of Biological Chemistry, 286
S. Cromphaut, M. Dewerchin, J. Hoenderop, I. Stockmans, E. Herck, S. Kato, R. Bindels, D. Collen, P. Carmeliet, R. Bouillon, G. Carmeliet (2001)
Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects
Proceedings of the National Academy of Sciences of the United States of America, 98
Xijie Yu, O. Ibrahimi, R. Goetz, Fuming Zhang, S. Davis, H. Garringer, R. Linhardt, D. Ornitz, M. Mohammadi, K. White (2005)
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.
Endocrinology, 146 11
M. Melamed, E. Michos, W. Post, B. Astor (2008)
25-hydroxyvitamin D levels and the risk of mortality in the general population.
Archives of internal medicine, 168 15
T. Belle, C. Gysemans, C. Mathieu (2011)
Vitamin D in autoimmune, infectious and allergic diseases: a vital player?
Best practice & research. Clinical endocrinology & metabolism, 25 4
B. Benn, Dare Ajibade, A. Porta, P. Dhawan, M. Hediger, Ji-Bin Peng, Yi Jiang, G. Oh, E. Jeung, L. Lieben, R. Bouillon, G. Carmeliet, S. Christakos (2008)
Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k.
Endocrinology, 149 6
L. Lieben, Bryan Benn, Dare Ajibade, I. Stockmans, K. Moermans, Matthias Hediger, Ji-Bin Peng, Sylvia Christakos, Roger Bouillon, G. Carmeliet (2010)
Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis.
Bone, 47 2
(2008)
Vitamin D gene regulation In: Principles of Bone Biology, edited by Bilezikian
P. Mancuso, Ayesha Rahman, S. Hershey, Loredana Dandu, Karl Nibbelink, R. Simpson (2008)
1,25-Dihydroxyvitamin-D3 Treatment Reduces Cardiac Hypertrophy and Left Ventricular Diameter in Spontaneously Hypertensive Heart Failure-prone (cp/+) Rats Independent of Changes in Serum Leptin
Journal of Cardiovascular Pharmacology, 51
Kan Yang, N. Kurihara, K. Fan, H. Newmark, B. Rigas, L. Bancroft, G. Corner, E. Livote, M. Lesser, W. Edelmann, A. Velcich, M. Lipkin, L. Augenlicht (2008)
Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.
Cancer research, 68 19
J. Forman, Jamil Scott, K. Ng, B. Drake, E. Suarez, D. Hayden, G. Bennett, P. Chandler, B. Hollis, K. Emmons, E. Giovannucci, C. Fuchs, A. Chan (2013)
Effect of Vitamin D Supplementation on Blood Pressure in Blacks
Hypertension, 61
M. Hu, K. Shiizaki, M. Kuro-o, O. Moe (2013)
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
Annual review of physiology, 75
J. Kanis, N. Burlet, C. Cooper, P. Delmas, J. Reginster, F. Borgstrom, R. Rizzoli, on Osteoarthritis (2008)
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Osteoporosis International, 19
M. Park, Ji Lee, Myung Park, J. Hwang, H. Shim, Sang‐Hee Cho, I. Chung, W. Bae (2012)
Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model
Journal of Korean Medical Science, 27
Mark Bower, Robert Stein, A. Hedley, R. Coombes, K. Colston, J. Gazet, H. Ford (1991)
Topical calcipotriol treatment in advanced breast cancer
The Lancet, 337
L. Nonn, Lihong Peng, D. Feldman, D. Peehl (2006)
Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.
Cancer research, 66 8
H. Brenza, H. DeLuca (2000)
Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3.
Archives of biochemistry and biophysics, 381 1
A. Bhalla, E. Amento, T. Clemens, M. Holick, S. Krane (1983)
Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.
The Journal of clinical endocrinology and metabolism, 57 6
C. Engelman, T. Fingerlin, C. Langefeld, P. Hicks, S. Rich, L. Wagenknecht, D. Bowden, J. Norris (2008)
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.
The Journal of clinical endocrinology and metabolism, 93 9
Katie Williams, H. DeLuca (2007)
Characterization of intestinal phosphate absorption using a novel in vivo method.
American journal of physiology. Endocrinology and metabolism, 292 6
M. Campbell, E. Elstner, S. Holden, M. Uskoković, H. Koeffler (1997)
Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.
Journal of molecular endocrinology, 19 1
D. Trivedi, R. Doll, K. Khaw (2003)
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial
BMJ : British Medical Journal, 326
C. Garland, F. Garland (1980)
Do sunlight and vitamin D reduce the likelihood of colon cancer?
International journal of epidemiology, 9 3
Anping Chen, B. Davis, M. Sitrin, T. Brasitus, M. Bissonnette (2002)
Transforming growth factor-β1 signaling contributes to Caco-2 cell growth inhibition induced by 1,25(OH)2D3
American Journal of Physiology-gastrointestinal and Liver Physiology, 283
A. Villagra, F. Cruzat, Loreto Carvallo, R. Paredes, J. Olate, A. Wijnen, G. Stein, J. Lian, J. Stein, A. Imbalzano, M. Montecino (2006)
Chromatin Remodeling and Transcriptional Activity of the Bone-specific Osteocalcin Gene Require CCAAT/Enhancer-binding Protein β-dependent Recruitment of SWI/SNF Activity*
Journal of Biological Chemistry, 281
A. Fleck (1989)
LATITUDE AND ISCHAEMIC HEART DISEASE
The Lancet, 333
J. Hoenderop, O. Dardenne, Monique Abel, A. Kemp, C. Os, R. St-Arnaud, R. Bindels (2002)
Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25‐dihydroxyvitamin D3 in 25hydroxyvitamin D3‐1α‐hydroxylase knockout mice
The FASEB Journal, 16
Ann Burgaz, N. Orsini, S. Larsson, A. Wolk (2011)
Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis
Journal of Hypertension, 29
K. Kupferschmidt (2012)
Uncertain verdict as vitamin D goes on trial.
Science, 337 6101
Shun‐Ai Li, Masami Watanabe, H. Yamada, A. Nagai, M. Kinuta, K. Takei (2004)
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice.
Cell structure and function, 29 4
Zeev Hochberg, D. Tiosano, L. Even (1992)
Calcium therapy for calcitriol-resistant rickets.
The Journal of pediatrics, 121 5 Pt 1
Wei Zheng, Fariba Tayyari, G. Gowda, D. Raftery, E. McLamore, Jin Shi, D. Porterfield, Shawn Donkin, B. Bequette, D. Teegarden (2013)
1,25-Dihydroxyvitamin D regulation of glucose metabolism in Harvey-ras transformed MCF10A human breast epithelial cells
The Journal of Steroid Biochemistry and Molecular Biology, 138
Z. Hegyi, S. Zwicker, D. Bureik, M. Perić, Sarah Koglin, A. Batycka‐Baran, J. Prinz, T. Ruzicka, J. Schauber, R. Wolf (2012)
Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 "alarmins" psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis.
The Journal of investigative dermatology, 132 5
S. Caini, M. Boniol, G. Tosti, S. Magi, M. Medri, I. Stanganelli, D. Palli, M. Assedi, V. Marmol, S. Gandini (2014)
Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: a comprehensive review and meta-analysis.
European journal of cancer, 50 15
A. Norman, Jian‐Yuan Zhou, H. Henry, M. Uskoković, H. Koeffler (1990)
Structure-Function Studies on Analogues of 1α,25-Dihydroxyvitamin D3: Differential Effects on Leukemic Cell Growth, Differentiation, and Intestinal Calcium Absorption
Cancer Research, 50
S. Akhter, Galina Kutuzova, S. Christakos, H. DeLuca (2007)
Calbindin D9k is not required for 1,25-dihydroxyvitamin D3-mediated Ca2+ absorption in small intestine.
Archives of biochemistry and biophysics, 460 2
Wei Zheng, Yixia Xie, Gang Li, J. Kong, Jian Feng, Y. Li (2004)
Critical Role of Calbindin-D28k in Calcium Homeostasis Revealed by Mice Lacking Both Vitamin D Receptor and Calbindin-D28k*
Journal of Biological Chemistry, 279
K. Dalhoff, J. Dancey, L. Astrup, T. Skovsgaard, K. Hamberg, FJ Lofts, O. Rosmorduc, S. Erlinger, J. Hansen, W. Steward, T. Skov, F. Burcharth, T. Evans (2003)
A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma
British Journal of Cancer, 89
E. Guallar, S. Stranges, C. Mulrow, L. Appel, E. Miller (2013)
Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements
Annals of Internal Medicine, 159
S. Sprague, F. Llach, M. Amdahl, Carol Taccetta, D. Batlle (2003)
Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism.
Kidney international, 63 4
R. St-Arnaud (2010)
CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24
The Journal of Steroid Biochemistry and Molecular Biology, 121
O. Andrukhova, S. Slavic, Ute Zeitz, S. Riesen, M. Heppelmann, T. Ambrisko, Mato Markovic, W. Kuebler, R. Erben (2014)
Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice.
Molecular endocrinology, 28 1
B. Tang, G. Eslick, C. Nowson, Caroline Smith, A. Bensoussan (2007)
Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis
The Lancet, 370
P. Autier, M. Boniol, C. Pizot, P. Mullie (2014)
Vitamin D status and ill health: a systematic review.
The lancet. Diabetes & endocrinology, 2 1
P. Kovalenko, Zhentao Zhang, M. Cui, S. Clinton, J. Fleet (2010)
1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1
BMC Genomics, 11
I. Pickholtz, Shira Saadyan, G. Keshet, Victor Wang, Rachel Cohen, P. Bouwman, J. Jonkers, S. Byers, M. Papa, R. Yarden (2014)
Cooperation between BRCA 1 and vitamin D is critical for histone acetylation of the p 21 waf 1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells
Su’e Chang, Ling Gao, Yang Yang, D. Tong, B. Guo, Liying Liu, Zongfang Li, T. Song, Chen Huang (2015)
miR-145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells
Oncotarget, 6
Carly Kemmis, J. Welsh (2008)
Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway
Journal of Cellular Biochemistry, 105
S. Christakos, L. Lieben, R. Masuyama, G. Carmeliet (2014)
Vitamin D endocrine system and the intestine.
BoneKEy reports, 3
Marie-France Penet, P. Winnard, R. Marik, S. Nimmagadda, M. Pomper, Z. Bhujwalla (2011)
Abstract 5276: Exploration of the cachectic phenotype
Cancer Research, 71
J. Hsia, G. Heiss, Hong Ren, M. Allison, N. Dolan, P. Greenland, S. Heckbert, K. Johnson, J. Manson, S. Sidney, M. Trevisan (2007)
Calcium/Vitamin D Supplementation and Cardiovascular Events
Circulation, 115
D. Bikle (2012)
Vitamin D and the skin: Physiology and pathophysiology
Reviews in Endocrine and Metabolic Disorders, 13
A. Norman, P. Manchand, M. Uskoković, W. Okamura, J. Takeuchi, J. Bishop, J. Hisatake, H. Koeffler, S. Peleg (2000)
Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.
Journal of medicinal chemistry, 43 14
Steven Mackey, Jennifer Heymont, H. Kronenberg, M. Demay (1996)
Vitamin D receptor binding to the negative human parathyroid hormone vitamin D response element does not require the retinoid x receptor.
Molecular endocrinology, 10 3
F. Llach, M. Yudd (2001)
Paricalcitol in dialysis patients with calcitriol-resistant secondary hyperparathyroidism.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 38 5 Suppl 5
I. Macintyre, K. Colston, I. Evans (1975)
The regulation of vitamin D metabolism
Calcified Tissue Research, 21
S. Christakos, T. Seth, J. Hirsch, A. Porta, A. Moulas, P. Dhawan (2013)
Vitamin D biology revealed through the study of knockout and transgenic mouse models.
Annual review of nutrition, 33
M. Haussler, G. Whitfield, I. Kaneko, I. Kaneko, C. Haussler, David Hsieh, J. Hsieh, P. Jurutka, P. Jurutka (2012)
Molecular Mechanisms of Vitamin D Action
Calcified Tissue International, 92
E. Farrow, S. Davis, Lelia Summers, K. White (2009)
Initial FGF23-mediated signaling occurs in the distal convoluted tubule.
Journal of the American Society of Nephrology : JASN, 20 5
David Martins, Myles Wolf, Deyu Pan, Ashraf Zadshir, N. Tareen, Ravi Thadhani, Arnold Felsenfeld, Barton Levine, R. Mehrotra, Keith Norris (2007)
Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey.
Archives of internal medicine, 167 11
O. Dardenne, J. Prud’homme, A. Arabian, F. Glorieux, R. St-Arnaud (2001)
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets.
Endocrinology, 142 7
Lee Zella, M. Meyer, R. Nerenz, J. Pike (2009)
The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes.
Endocrinology, 150 8
H. Armbrecht, T. Zenser, B. Davis (1980)
Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat.
The Journal of clinical investigation, 66 5
F. Baeke, T. Takiishi, H. Korf, C. Gysemans, C. Mathieu (2010)
Vitamin D: modulator of the immune system.
Current opinion in pharmacology, 10 4
P. Arora, Yanna Song, J. Dusek, G. Plotnikoff, M. Sabatine, Susan Cheng, A. Valcour, Heather Swales, B. Taylor, E. Carney, Derek Guanaga, Joseph Young, Courtney Karol, Michael Torre, A. Azzahir, Semerit Strachan, Dillon O'Neill, M. Wolf, F. Harrell, C. Newton‐Cheh, Thomas Wang (2015)
Vitamin D Therapy in Individuals With Prehypertension or Hypertension: The DAYLIGHT Trial
Circulation, 131
J. Russell, Sheela Ashok, N. Koszewski (1999)
Vitamin D Receptor Interactions with the Rat Parathyroid Hormone Gene: Synergistic Effects Between Two Negative Vitamin D Response Elements
Journal of Bone and Mineral Research, 14
A. Nykjaer, D. Dragun, D. Walther, H. Vorum, C. Jacobsen, J. Herz, F. Melsen, E. Christensen, T. Willnow (1999)
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Cell, 96
Tanya Seth-Vollenweider, Sneha Joshi, P. Dhawan, S. Sif, S. Christakos (2014)
Novel Mechanism of Negative Regulation of 1,25-Dihydroxyvitamin D3-induced 25-Hydroxyvitamin D3 24-Hydroxylase (Cyp24a1) Transcription
The Journal of Biological Chemistry, 289
Teo Soleymani, Tracy Hung, J. Soung (2015)
The role of vitamin D in psoriasis: a review
International Journal of Dermatology, 54
M. Snijder, M. Snijder, P. Lips, J. Seidell, J. Seidell, Marjolein Visser, Marjolein Visser, Dorly Deeg, J. Dekker, R. Dam, R. Dam (2007)
Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population‐based study in older men and women
Journal of Internal Medicine, 261
M. Cui, Qiang Li, Robert Johnson, J. Fleet (2012)
Villin promoter‐mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild‐type and vitamin D receptor knockout mice
Journal of Bone and Mineral Research, 27
H. Dobnig, S. Pilz, H. Scharnagl, W. Renner, U. Seelhorst, B. Wellnitz, J. Kinkeldei, B. Boehm, G. Weihrauch, W. Maerz (2008)
Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality.
Archives of internal medicine, 168 12
A. Mondul, S. Weinstein, R. Horst, M. Purdue, D. Albanes (2012)
Serum Vitamin D and Risk of Bladder Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Cancer Epidemiology, Biomarkers & Prevention, 21
D. d'Ambrosio, M. Cippitelli, M. Cocciolo, D. Mazzeo, P. Lucia, R. Lang, F. Sinigaglia, P. Panina-Bordignon (1998)
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
The Journal of clinical investigation, 101 1
M. González, Petra Samenfeld, M. Peräkylä, C. Carlberg (2003)
Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor.
Molecular endocrinology, 17 10
V. Sung, D. Feldman (2000)
1,25-Dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration
Molecular and Cellular Endocrinology, 164
S. Wu, S. Ho, Liu Zhong (2010)
Effects of Vitamin D Supplementation on Blood Pressure
Southern Medical Journal, 103
J. Kendrick, G. Targher, G. Smits, M. Chonchol (2009)
25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey.
Atherosclerosis, 205 1
M. Favus (1985)
Factors that influence absorption and secretion of calcium in the small intestine and colon.
The American journal of physiology, 248 2 Pt 1
H. DeLuca (2008)
Evolution of our understanding of vitamin D.
Nutrition reviews, 66 10 Suppl 2
P. Kerkhof, J. Berth‐Jones, C. Griffiths, P. Harrison, H. Hönigsmann, R. Marks, R. Roelandts, E. Schöpf, C. Trompke (2002)
Long‐term efficacy and safety of tacalcitol ointment in patients with chronic plaque psoriasis
British Journal of Dermatology, 146
S. Kunutsor, S. Burgess, P. Munroe, H. Khan (2013)
Vitamin D and high blood pressure: causal association or epiphenomenon?
European Journal of Epidemiology, 29
A. Handel, G. Sandve, G. Disanto, Antonio Berlanga-Taylor, G. Gallone, H. Hanwell, F. Drabløs, G. Giovannoni, G. Ebers, S. Ramagopalan (2013)
Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease
BMC Medicine, 11
R. Borkowski, Liqin Du, Zhenze Zhao, E. McMillan, A. Kosti, Chin-Rang Yang, M. Suraokar, I. Wistuba, A. Gazdar, J. Minna, M. White, A. Pertsemlidis (2015)
Genetic mutation of p53 and suppression of the miR-17∼92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling.
Cancer research, 75 4
Erin Stashi, B. York, B. O’Malley (2014)
Steroid receptor coactivators: servants and masters for control of systems metabolism
Trends in Endocrinology & Metabolism, 25
Yuzhuo Pan, Wenqing Gao, A. Yu (2009)
MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting The online version of this article (available at http://dmd.aspetjournals.org) contains supplemental material.
Drug Metabolism and Disposition, 37
Toshio Matsumoto, T. Miki, H. Hagino, T. Sugimoto, Sumiaki Okamoto, T. Hirota, Y. Tanigawara, Y. Hayashi, M. Fukunaga, M. Shiraki, Toshitaka Nakamura (2005)
A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.
The Journal of clinical endocrinology and metabolism, 90 9
A. Annalora, D. Goodin, W. Hong, Qinghai Zhang, E. Johnson, C. Stout (2010)
Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.
Journal of molecular biology, 396 2
Yonghua Xu, Xiaoping Shao, Ya-cheng Yao, Lijian Xu, Liang Chang, Zhuojuan Jiang, Zhaofen Lin (2014)
Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis
Journal of Cancer Research and Clinical Oncology, 140
S. Swami, A. Krishnan, Jennifer Wang, K. Jensen, R. Horst, M. Albertelli, D. Feldman (2012)
Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer.
Endocrinology, 153 6
J. Arnaud, J. Constans (1993)
Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP)
Human Genetics, 92
D. Dinour, P. Beckerman, Liat Ganon, K. Tordjman, Z. Eisenstein, E. Holtzman (2013)
Loss-of-function mutations of CYP24A1, the vitamin D 24-hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
The Journal of urology, 190 2
Jun Zhang, M. Chalmers, K. Stayrook, L. Burris, Yongjun Wang, Scott Busby, B. Pascal, Ruben Garcia-Ordonez, J. Bruning, M. Istrate, D. Kojetin, J. Dodge, T. Burris, P. Griffin (2011)
DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
Nature structural & molecular biology, 18
L. Reimers, K. Crew, P. Bradshaw, R. Santella, S. Steck, Iryna Sirosh, M. Terry, D. Hershman, E. Shane, S. Cremers, E. Dworakowski, S. Teitelbaum, A. Neugut, M. Gammon (2015)
Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk
Cancer Causes & Control, 26
X. Bosch (1998)
Hypercalcemia due to endogenous overproduction of 1,25-dihydroxyvitamin D in Crohn's disease.
Gastroenterology, 114 5
W. Wade, M. Willingham, C. Koumenis, S. Cramer (2002)
p27 Kip1 Is Essential for the Antiproliferative Action of 1,25-Dihydroxyvitamin D3 in Primary, but Not Immortalized, Mouse Embryonic Fibroblasts*
The Journal of Biological Chemistry, 277
Zhiwei Li, Z. Jia, Yong Gao, D. Xie, D. Wei, Jiujie Cui, L. Mishra, Suyun Huang, Yanqiao Zhang, K. Xie (2014)
Activation of Vitamin D Receptor Signaling Downregulates the Expression of Nuclear FOXM1 Protein and Suppresses Pancreatic Cancer Cell Stemness
Clinical Cancer Research, 21
Elżbieta Gocek, Xuening Wang, Xiuping Liu, Changfeng Liu, G. Studzinski (2011)
MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis.
Cancer research, 71 19
J. Zella, L. Plum, D. Plowchalk, Michael Potochoiba, M. Clagett-Dame, H. DeLuca (2014)
Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women
American Journal of Nephrology, 39
R. Masuyama, Y. Nakaya, S. Katsumata, Y. Kajita, M. Uehara, Shinya Tanaka, A. Sakai, S. Kato, Toshitaka Nakamura, Kazuharu Suzuki (2003)
Dietary Calcium and Phosphorus Ratio Regulates Bone Mineralization and Turnover in Vitamin D Receptor Knockout Mice by Affecting Intestinal Calcium and Phosphorus Absorption
Journal of Bone and Mineral Research, 18
N. Koszewski, A. Alimov, O. Park-Sarge, H. Malluche (2004)
Suppression of the Human Parathyroid Hormone Promoter by Vitamin D Involves Displacement of NF-Y Binding to the Vitamin D Response Element*
Journal of Biological Chemistry, 279
O. Andrukhova, A. Smorodchenko, M. Egerbacher, C. Streicher, Ute Zeitz, R. Goetz, V. Shalhoub, M. Mohammadi, E. Pohl, B. Lanske, R. Erben (2014)
FGF23 promotes renal calcium reabsorption through the TRPV5 channel
The EMBO Journal, 33
D. Tiosano, S. Hadad, Zhensheng Chen, Aleksandra Nemirovsky, Vardit Gepstein, D. Militianu, Y. Weisman, S. Abrams (2011)
Calcium absorption, kinetics, bone density, and bone structure in patients with hereditary vitamin D-resistant rickets.
The Journal of clinical endocrinology and metabolism, 96 12
Sewon Kang, S. Yi, C. Griffiths, L. Fancher, T. Hamilton, Jee-Ho Choi (1998)
Calcipotriene‐induced improvement in psoriasis is associated with reduced interleukin‐8 and increased interleukin‐10 levels within lesions
British Journal of Dermatology, 138
D. Zehnder, Katie Evans, M. Kilby, J. Bulmer, B. Innes, P. Stewart, M. Hewison (2002)
The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua.
The American journal of pathology, 161 1
Mian Li, Peizhan Chen, Jing-quan Li, Rui-ai Chu, Dongling Xie, Hui Wang (2014)
Review: the impacts of circulating 25-hydroxyvitamin D levels on cancer patient outcomes: a systematic review and meta-analysis.
The Journal of clinical endocrinology and metabolism, 99 7
J. Pike, M. Meyer (2010)
The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3).
Endocrinology and metabolism clinics of North America, 39 2
Yanbin Dong, I. Stallmann-Jorgensen, N. Pollock, R. Harris, Daniel Keeton, Ying Huang, Ke Li, R. Bassali, De-huang Guo, Jeffrey Thomas, G. Pierce, Jennifer White, M. Holick, Haidong Zhu (2010)
A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness.
The Journal of clinical endocrinology and metabolism, 95 10
Thomas Larsen, F. Mose, J. Bech, A. Hansen, E. Pedersen (2012)
Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial.
American journal of hypertension, 25 11
A. Zisman, W. Ghantous, Pamela Schinleber, Laurie Roberts, S. Sprague (2005)
Inhibition of Parathyroid Hormone: A Dose Equivalency Study of Paricalcitol and Doxercalciferol
American Journal of Nephrology, 25
D. Lee, M. Walling, B. Levine, U. Gafter, V. Silis, A. Hodsman, J. Coburn (1981)
Intestinal and metabolic effect of 1,25-dihydroxyvitamin D3 in normal adult rat.
The American journal of physiology, 240 1
K. Jablonski, M. Chonchol, G. Pierce, Ashley Walker, D. Seals (2011)
25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults
Hypertension, 57
A. Schäfer, S. Emmert, Jochen Kruppa, S. Schubert, M. Tzvetkov, R. Mössner, K. Reich, C. Berking, M. Volkenandt, C. Pföhler, M. Schön, T. Vogt, I. König, J. Reichrath (2012)
No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case–control study
Archives of Dermatological Research, 304
Philip Liu, S. Stenger, Dominic Tang, R. Modlin (2007)
Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin1
The Journal of Immunology, 179
H. Ke, H. Qi, D. Crawford, H. Simmons, Gang Xu, Mei Li, L. Plum, M. Clagett-Dame, H. DeLuca, D. Thompson, T. Brown (2005)
A New Vitamin D Analog, 2MD, Restores Trabecular and Cortical Bone Mass and Strength in Ovariectomized Rats With Established Osteopenia
Journal of Bone and Mineral Research, 20
Robinson Cj, E. Spanos, James Mf, J. Pike, M. Haussler, Makeen Am, C. Hillyard, I. Macintyre (1982)
Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat.
The Journal of endocrinology, 94 3
R. Chun, B. Peercy, E. Orwoll, C. Nielson, J. Adams, M. Hewison (2014)
Vitamin D and DBP: The free hormone hypothesis revisited
The Journal of Steroid Biochemistry and Molecular Biology, 144
O. Golovko, N. Nazarova, P. Tuohimaa (2005)
Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells.
Life sciences, 77 5
J. Cannata-Andía, A. Macleod (2009)
Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease- Mineral and Bone Disorder (CKD-MBD)
E. Golub (2009)
Role of matrix vesicles in biomineralization.
Biochimica et biophysica acta, 1790 12
M. Larriba, J. González-Sancho, A. Barbáchano, Núria Niell, Gemma Ferrer-Mayorga, A. Muñoz (2013)
Vitamin D Is a Multilevel Repressor of Wnt/β-Catenin Signaling in Cancer Cells
Cancers, 5
A. Giangreco, Avani Vaishnav, Dennis Wagner, A. Finelli, N. Fleshner, T. Kwast, R. Vieth, L. Nonn (2013)
Tumor Suppressor microRNAs, miR-100 and -125b, Are Regulated by 1,25-dihydroxyvitamin D in Primary Prostate Cells and in Patient Tissue
Cancer Prevention Research, 6
T. Weber, Shiguang Liu, O. Indridason, L. Quarles (2003)
Serum FGF23 Levels in Normal and Disordered Phosphorus Homeostasis
Journal of Bone and Mineral Research, 18
J. Forman, Jonathan Williams, N. Fisher (2010)
Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans
Hypertension, 55
S. Pilz, M. Gaksch, K. Kienreich, M. Grübler, N. Verheyen, A. Fahrleitner-Pammer, Gerlies Treiber, C. Drechsler, B. Hartaigh, B. Obermayer-Pietsch, V. Schwetz, F. Aberer, J. Mader, H. Scharnagl, A. Meinitzer, E. Lerchbaum, J. Dekker, A. Zittermann, W. März, A. Tomaschitz (2015)
Effects of Vitamin D on Blood Pressure and Cardiovascular Risk Factors: A Randomized Controlled Trial
Hypertension, 65
Katrina Simmons, Sarah Beaudin, C. Narvaez, J. Welsh (2015)
Gene Signatures of 1,25‐Dihydroxyvitamin D3 Exposure in Normal and Transformed Mammary Cells
Journal of Cellular Biochemistry, 116
S. Padi, Qunshu Zhang, Y. Rustum, C. Morrison, B. Guo (2013)
MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice.
Gastroenterology, 145 2
P. Malloy, R. Xu, Lihong Peng, P. Clark, D. Feldman (2002)
A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
Molecular endocrinology, 16 11
J. Höbaus, Doris Hummel, U. Thiem, I. Fetahu, A. Aggarwal, L. Müllauer, G. Heller, G. Egger, I. Mesteri, S. Baumgartner-Parzer, E. Kallay (2013)
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer
International Journal of Cancer. Journal International du Cancer, 133
T. Belle, An-Sofie Vanherwegen, Dorien Feyaerts, P. Clercq, A. Verstuyf, H. Korf, C. Gysemans, C. Mathieu (2014)
1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients
PLoS ONE, 9
Yongji Wang, Jinge Zhu, H. DeLuca (2014)
Identification of the Vitamin D Receptor in Osteoblasts and Chondrocytes But Not Osteoclasts in Mouse Bone
Journal of Bone and Mineral Research, 29
Jiyoung Ahn, Kai Yu, R. Stolzenberg-Solomon, K. Simon, M. McCullough, L. Gallicchio, E. Jacobs, A. Ascherio, K. Helzlsouer, K. Jacobs, Qizhai Li, S. Weinstein, M. Purdue, J. Virtamo, R. Horst, W. Wheeler, S. Chanock, D. Hunter, Richard Hayes, P. Kraft, D. Albanes (2010)
Genome-wide association study of circulating vitamin D levels
Human Molecular Genetics, 19
M. Cantorna (2010)
International Immunonutrition Workshop Session 2 : Micronutrients and the immune system Mechanisms underlying the effect of vitamin D on the immune system
Isabelle Clinckspoor, Anne-Catherine Gérard, J. Sande, M. Many, L. Verlinden, R. Bouillon, G. Carmeliet, C. Mathieu, A. Verstuyf, B. Decallonne (2012)
The Vitamin D Receptor in Thyroid Development and Function
European Thyroid Journal, 1
P. Ebeling, M Sandgren, E DiMagno, A Lane, H. DeLuca, B. Riggs (1992)
Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women.
The Journal of clinical endocrinology and metabolism, 75 1
R. Scragg, M. Sowers, Colin Bell (2007)
Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey.
American journal of hypertension, 20 7
D. Bikle (2009)
Extra Renal Synthesis of 1,25-dihydroxyvitamin D and its Health Implications
Clinical Reviews in Bone and Mineral Metabolism, 7
M. Stio, M. Martinesi, A. Simoni, Ulrich Zuegel, A. Steinmeyer, R. Santi, C. Treves, G. Nesi (2011)
The novel vitamin D analog ZK191784 inhibits prostate cancer cell invasion.
Anticancer research, 31 12
J. Lundqvist, S. Hansen, A. Lykkesfeldt (2013)
Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase.
Biochimica et biophysica acta, 1833 1
J. Pike, S. Lee, M. Meyer (2014)
Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms.
BoneKEy reports, 3
Dan Wang, Omar de-la-Paz, J. Zhai, Dian-Wu Liu (2013)
Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies
Tumor Biology, 34
M. Holick (2006)
Resurrection of vitamin D deficiency and rickets.
The Journal of clinical investigation, 116 8
T. Shimada, S. Mizutani, T. Muto, T. Yoneya, Rieko Hino, S. Takeda, Y. Takeuchi, T. Fujita, S. Fukumoto, T. Yamashita (2001)
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Proceedings of the National Academy of Sciences of the United States of America, 98
Chunlei Zhou, F. Lu, K. Cao, Di Xu, D. Goltzman, D. Miao (2008)
Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice.
Kidney international, 74 2
K. Spach, F. Nashold, B. Dittel, C. Hayes (2006)
IL-10 Signaling Is Essential for 1,25-Dihydroxyvitamin D3-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis1
The Journal of Immunology, 177
PC Dheerendra, Vinay Sakhuja, H. Kohli, Vivekanand Jha (2013)
Efficacy and safety of oral doxercalciferol in the management of secondary hyperparathyroidism in chronic kidney disease stage 4
Indian Journal of Nephrology, 23
H. Kawashima, S. Torikai, K. Kurokawa (1981)
Calcitonin selectively stimulates 25-hydroxyvitamin D3-1α-hydroxylase in proximal straight tubule of rat kidney
Nature, 291
G. Trujillo, D. Habiel, Lingyin Ge, Mahalakshmi Ramadass, N. Cooke, R. Kew (2013)
Neutrophil Recruitment to the Lung in Both C5a- and CXCL1-Induced Alveolitis Is Impaired in Vitamin D–Binding Protein–Deficient Mice
The Journal of Immunology, 191
L. Whitlatch, Michael Young, G. Schwartz, J. Flanagan, K. Burnstein, B. Lokeshwar, E. Rich, M. Holick, Tai-Chi Chen (2002)
25-Hydroxyvitamin D-1α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer
The Journal of Steroid Biochemistry and Molecular Biology, 81
R. Bouillon, N. Schoor, E. Gielen, S. Boonen, C. Mathieu, D. Vanderschueren, P. Lips (2013)
Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine.
The Journal of clinical endocrinology and metabolism, 98 8
T. Huet, H. Maehr, HongJin Lee, M. Uskoković, N. Suh, D. Moras, N. Rochel (2011)
Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.
MedChemComm, 2 5
D. Bartel (2004)
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
Cell, 116
Lu-Xuan Wang, Yiqing Song, J. Manson, S. Pilz, W. März, K. Michaëlsson, A. Lundqvist, S. Jassal, E. Barrett-Connor, Cuilin Zhang, C. Eaton, H. May, Jeffrey Anderson, H. Sesso (2012)
Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies
Circulation: Cardiovascular Quality and Outcomes, 5
M. Heiden, L. Cantley, C. Thompson (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Science, 324
K. Margolis, R. Ray, L. Horn, J. Manson, M. Allison, H. Black, S. Beresford, S. Connelly, J. Curb, R. Grimm, T. Kotchen, L. Kuller, S. Wassertheil-Smoller, C. Thomson, J. Torner (2008)
Effect of Calcium and Vitamin D Supplementation on Blood Pressure: The Women's Health Initiative Randomized Trial
Hypertension, 52
T. Shinki, H. Shimada, S. Wakino, H. Anazawa, M. Hayashi, T. Saruta, H. DeLuca, T. Suda (1997)
Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA.
Proceedings of the National Academy of Sciences of the United States of America, 94 24
R. Ray, M. Banks, Hilal Abuzahra, Vikram Eddy, K. Persons, M. Lucia, J. Lambert, M. Holick (2012)
Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model.
Anticancer research, 32 3
S. Fortmann, B. Burda, Caitlyn Senger, Jennifer Lin, E. Whitlock (2013)
Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force
Annals of Internal Medicine, 159
Peter Brøndum-Jacobsen, B. Nordestgaard, P. Schnohr, M. Benn (2013)
25‐Hydroxyvitamin D and symptomatic ischemic stroke: An Original Study and Meta‐Analysis
Annals of Neurology, 73
G. Tocchini-Valentini, N. Rochel, J. Wurtz, A. Mitschler, D. Moras (2001)
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands
Proceedings of the National Academy of Sciences of the United States of America, 98
F. Glorieux, J. Pettifor (2014)
Vitamin D/dietary calcium deficiency rickets and pseudo-vitamin D deficiency rickets.
BoneKEy reports, 3
A. Need, P. O’Loughlin, H. Morris, P. Coates, M. Horowitz, B. Nordin (2008)
Vitamin D Metabolites and Calcium Absorption in Severe Vitamin D Deficiency
Journal of Bone and Mineral Research, 23
J. Vanhooke, M. Benning, C. Bauer, J. Pike, H. DeLuca (2004)
Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide.
Biochemistry, 43 14
M. Washington, Jung‐Sun Kim, N. Weigel (2011)
1α,25‐dihydroxyvitamin D3 inhibits C4‐2 prostate cancer cell growth via a retinoblastoma protein (Rb)‐independent G1 arrest
The Prostate, 71
K. Wesseling-Perry, R. Pereira, S. Sahney, B. Gales, He-jing Wang, R. Elashoff, H. Jüppner, I. Salusky (2011)
Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism.
Kidney international, 79 1
R. St-Arnaud, R. St-Arnaud, A. Arabian, R. Travers, F. Barletta, M. Raval-Pandya, K. Chapin, J. Depovere, C. Mathieu, S. Christakos, M. Demay, F. Glorieux, F. Glorieux (2000)
Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D.
Endocrinology, 141 7
Thomas Wang, M. Pencina, S. Booth, P. Jacques, E. Ingelsson, Katherine Lanier, E. Benjamin, R. D'Agostino, M. Wolf, R. Vasan (2008)
Vitamin D Deficiency and Risk of Cardiovascular Disease
Circulation, 117
T. Huet, G. Laverny, F. Ciesielski, Ferdinand Molnár, T. Ramamoorthy, A. Belorusova, P. Antony, N. Potier, D. Metzger, D. Moras, N. Rochel (2015)
A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Cell reports, 10 4
J. Constans, S. Hazout, R. Garruto, D. Gajdusek, E. Spees (1985)
Population distribution of the human vitamin D binding protein: anthropological considerations.
American journal of physical anthropology, 68 1
Salma Essa, Nicole Denzer, Ulrich Mahlknecht, R. Klein, E. Collnot, W. Tilgen, Jörg Reichrath (2010)
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells
The Journal of Steroid Biochemistry and Molecular Biology, 121
Ravi Kasiappan, Zheng Shen, A. Tse, U. Jinwal, Jinfu Tang, P. Lungchukiet, Yuefeng Sun, P. Kruk, S. Nicosia, X. Zhang, Wenlong Bai (2012)
1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498*
The Journal of Biological Chemistry, 287
C. Carlberg (2014)
Genome-wide (over)view on the actions of vitamin D
Frontiers in Physiology, 5
G. Ferreira, C. Gysemans, J. Demengeot, J. Cunha, An-Sofie Vanherwegen, L. Overbergh, T. Belle, F. Pauwels, A. Verstuyf, H. Korf, C. Mathieu (2014)
1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice
The Journal of Immunology, 192
Sneha Joshi, Luiz Pantalena, Xikui Liu, S. Gaffen, Hong Liu, C. Rohowsky-Kochan, K. Ichiyama, A. Yoshimura, L. Steinman, S. Christakos, S. Youssef (2011)
1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
Molecular and Cellular Biology, 31
P. Shaffer, D. Gewirth (2002)
Structural basis of VDR–DNA interactions on direct repeat response elements
The EMBO Journal, 21
H. Bischoff-Ferrari, T. Dietrich, E. Orav, B. Dawson-Hughes (2004)
Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults.
The American journal of medicine, 116 9
L. Galante, K. Colston, S. Macauley, I. Macintyre (1972)
Effect of Calcitonin on Vitamin D Metabolism
Nature, 238
Li Ooi, Hong Zhou, R. Kalak, Yu Zheng, A. Conigrave, M. Seibel, C. Dunstan (2010)
Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis.
Cancer research, 70 5
R. Nuti, G. Bianchi, M. Brandi, R. Caudarella, E. D'erasmo, C. Fiore, G. Isaia, G. Luisetto, M. Muratore, P. Oriente, S. Ortolani (2006)
Superiority of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis
Rheumatology International, 26
N. Strushkevich, S. Usanov, A. Plotnikov, Glenville Jones, Hee-won Park (2007)
Structural analysis of CYP2R1 in complex with vitamin D3.
Journal of molecular biology, 380 1
R. Masuyama, I. Stockmans, S. Torrekens, Riet Looveren, C. Maes, P. Carmeliet, R. Bouillon, G. Carmeliet (2006)
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts.
The Journal of clinical investigation, 116 12
F. Safadi, P. Thornton, H. Magiera, B. Hollis, M. Gentile, J. Haddad, S. Liebhaber, N. Cooke (1999)
Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein.
The Journal of clinical investigation, 103 2
M. O'Brien, D. Talbot, K. Maclennan, I. Smith (1993)
Inefficacy of calcipotriol In skin metastases from breast cancer
The Lancet, 342
V. Tangpricha, C. Spina, M. Yao, Tai Chen, M. Wolfe, M. Holick (2005)
Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice.
The Journal of nutrition, 135 10
S. Meeker, Audrey Seamons, J. Paik, P. Treuting, T. Brabb, W. Grady, L. Maggio‐Price (2014)
Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer.
Cancer research, 74 16
M. Witham, R. Price, A. Struthers, P. Donnan, C. Messow, I. Ford, M. Mcmurdo (2013)
Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension: the VitDISH randomized controlled trial.
JAMA internal medicine, 173 18
D. Bacic, M. Lehir, J. Biber, B. Kaissling, H. Murer, C. Wagner (2006)
The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone.
Kidney international, 69 3
Toshimasa ShinkiS, Cheng JinS, Atsushi NishimuraS, Yumiko NagaiS, Yoshihiko Ohyamas, Mitsuhide Noshiros, Kyuichiro Okudas, Tatsuo SudaSll (1992)
Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.
The Journal of biological chemistry, 267 19
J. So, Joseph Wahler, Soumyasri Gupta, David Salerno, H. Maehr, M. Uskoković, N. Suh (2015)
HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44+/CD24−/low tumor-initiating subpopulation in basal-like breast cancer
The Journal of Steroid Biochemistry and Molecular Biology, 148
M. Meyer, Paul Goetsch, J. Pike (2010)
A Downstream Intergenic Cluster of Regulatory Enhancers Contributes to the Induction of CYP24A1 Expression by 1α,25-Dihydroxyvitamin D3*
The Journal of Biological Chemistry, 285
Cheng-Yuan Kao, Yin Chen, Philip Thai, S. Wachi, Fei Huang, Christy Kim, R. Harper, R. Wu (2004)
IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Journal of immunology, 173 5
P. Tebben, D. Milliner, R. Horst, P. Harris, Ravinder Singh, Yanhong Wu, J. Foreman, P. Chelminski, R. Kumar (2012)
Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy.
The Journal of clinical endocrinology and metabolism, 97 3
A. Tomaschitz, S. Pilz, E. Ritz, T. Grammer, C. Drechsler, B. Boehm, W. März (2010)
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Clinica chimica acta; international journal of clinical chemistry, 411 17-18
Yanlei Ma, Peng Zhang, Feng Wang, Jian-jun Yang, Zhihua Liu, H. Qin (2011)
Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 28
J. Lemire, J. Adams, V. Kermani-Arab, A. Bakke, R. Sakai, S. Jordan (1985)
1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro.
Journal of immunology, 134 5
J. Pike, M. Meyer (2014)
Fundamentals of vitamin D hormone-regulated gene expression
The Journal of Steroid Biochemistry and Molecular Biology, 144
P. Ye, F. Rodriguez, S. Kanaly, K. Stocking, J. Schurr, P. Schwarzenberger, P. Oliver, Weitao Huang, Ping Zhang, Jason Zhang, J. Shellito, G. Bagby, S. Nelson, K. Charrier, J. Peschon, J. Kolls (2001)
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
The Journal of Experimental Medicine, 194
W. Waters, M. Palmer, B. Nonnecke, D. Whipple, R.L Horst (2004)
Mycobacterium bovis infection of vitamin D-deficient NOS2-/- mice.
Microbial pathogenesis, 36 1
J. Aljubeh, Jining Wang, Sareea Al-Remeithi, P. Malloy, D. Feldman (2011)
Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor
, 24
Y. Zhong, H. Armbrecht, S. Christakos (2009)
Calcitonin, a Regulator of the 25-Hydroxyvitamin D3 1α-Hydroxylase Gene*
Journal of Biological Chemistry, 284
F. Giallauria, Y. Milaneschi, Toshiko Tanaka, M. Maggio, M. Canepa, Palchamy Elango, C. Vigorito, E. Lakatta, L. Ferrucci, J. Strait (2012)
Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging.
The Journal of clinical endocrinology and metabolism, 97 10
D. Zehnder, Katie Evans, M. Kilby, J. Bulmer, B. Innes, P. Stewart, M. Hewison (2002)
The Ontogeny of 25-Hydroxyvitamin D3 1α-Hydroxylase Expression in Human Placenta and Decidua
American Journal of Pathology, 161
J. Stevenson, C. Hillyard, I. Macintyre, Hilary Cooper, M. Whitehead (1979)
A PHYSIOLOGICAL ROLE FOR CALCITONIN: PROTECTION OF THE MATERNAL SKELETON
The Lancet, 314
Darshana Durup, H. Jørgensen, J. Christensen, P. Schwarz, A. Heegaard, B. Lind (2012)
A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study.
The Journal of clinical endocrinology and metabolism, 97 8
Yanling Liu, Chenglin Li, Peizhan Chen, Xiaoguang Li, Mian Li, He Guo, Jing-quan Li, Rui-ai Chu, Hui Wang (2013)
Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis
PLoS ONE, 8
P. Dhawan, R. Weider, S. Christakos (2009)
CCAAT Enhancer-binding Protein α Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells*
Journal of Biological Chemistry, 284
M. Meyer, Makoto Watanuki, Sungtae Kim, N. Shevde, J. Pike (2006)
The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells.
Molecular endocrinology, 20 6
G. Ferreira, An-Sofie Vanherwegen, G. Eelen, Ana Gutiérrez, L. Lommel, K. Marchal, L. Verlinden, A. Verstuyf, Tatiane Nogueira, M. Georgiadou, F. Schuit, D. Eizirik, C. Gysemans, P. Carmeliet, L. Overbergh, C. Mathieu (2015)
Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways.
Cell reports, 10 5
C. Zierold, J. Nehring, H. DeLuca (2007)
Nuclear receptor 4A2 and C/EBPbeta regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1alpha-hydroxylase.
Archives of biochemistry and biophysics, 460 2
B. Boyan, J. Hurst-Kennedy, T. Denison, Z. Schwartz (2010)
24R,25-Dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1α,25(OH)2D3 in hypertrophic cells
The Journal of Steroid Biochemistry and Molecular Biology, 121
Yingben Xue, J. Fleet (2009)
Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice.
Gastroenterology, 136 4
K. Takeyama, S. Kitanaka, T. Sato, M. Kobori, J. Yanagisawa, S. Kato (1997)
25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis.
Science, 277 5333
Jung-Hwan Kim, Satoshi Yamaori, T. Tanabe, C. Johnson, K. Krausz, S. Kato, F. Gonzalez (2013)
Implication of intestinal VDR deficiency in inflammatory bowel disease.
Biochimica et biophysica acta, 1830 1
K. Stoffels, L. Overbergh, R. Bouillon, C. Mathieu (2007)
Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathway.
The Journal of steroid biochemistry and molecular biology, 103 3-5
P. Dhawan, R. Wei, Cheng Sun, A. Gombart, H. Koeffler, G. Diamond, S. Christakos (2015)
C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells
Journal of Cellular Physiology, 230
T. Willnow, A. Nykjaer (2010)
Cellular uptake of steroid carrier proteins—Mechanisms and implications
Molecular and Cellular Endocrinology, 316
K. Tsai, H. Heath, R. Kumar, B. Riggs (1984)
Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis.
The Journal of clinical investigation, 73 6
H. DeLuca, M. Cantorna (2001)
Vitamin D: its role and uses in immunology 1
The FASEB Journal, 15
S. Pervin, M. Hewison, M. Braga, L. Tran, R. Chun, A. Karam, G. Chaudhuri, Keith Norris, R. Singh (2013)
Down-Regulation of Vitamin D Receptor in Mammospheres: Implications for Vitamin D Resistance in Breast Cancer and Potential for Combination Therapy
PLoS ONE, 8
Lee Zella, N. Shevde, B. Hollis, N. Cooke, J. Pike (2008)
Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.
Endocrinology, 149 7
R. Scragg (1981)
Seasonality of cardiovascular disease mortality and the possible protective effect of ultra-violet radiation.
International journal of epidemiology, 10 4
D. Panda, D. Miao, I. Bolivar, Jiarong Li, Rujuan Huo, G. Hendy, D. Goltzman (2004)
Inactivation of the 25-Hydroxyvitamin D 1α-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis*
Journal of Biological Chemistry, 279
Petra Bareis, Giovanna Bises, Martin Bischof, H. Cross, M. Peterlik (2001)
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Biochemical and biophysical research communications, 285 4
T. Shinki, H. Shimada, S. Wakino, H. Anazawa, M. Hayashi, T. Saruta, H. DeLuca, T. Suda (1997)
Cloning and expression of rat 25-hydroxyvitamin D3-1α-hydroxylase cDNA
Proceedings of the National Academy of Sciences of the United States of America, 94
T. Okano, N. Tsugawa, S. Masuda, A. Takeuchi, T. Kobayashi, Y. Nishii (1989)
Protein-binding properties of 22-oxa-1 alpha,25-dihydroxyvitamin D3, a synthetic analogue of 1 alpha,25-dihydroxyvitamin D3.
Journal of nutritional science and vitaminology, 35 5
R. Jain, D. Trump, M. Egorin, Manuel Fernández, Candace Johnson, R. Ramanathan (2011)
A phase I study of the vitamin D3 analogue ILX23-7553 administered orally to patients with advanced solid tumors
Investigational New Drugs, 29
Rajiv Chowdhury, Sarah Stevens, Heather Ward, S. Chowdhury, Ayesha Sajjad, O. Franco (2012)
Circulating vitamin D, calcium and risk of cerebrovascular disease: a systematic review and meta-analysis
European Journal of Epidemiology, 27
M. Larriba, P. Ordóñez-Morán, I. Chicote, G. Martín-Fernández, I. Puig, A. Muñoz, H. Pálmer (2011)
Vitamin D Receptor Deficiency Enhances Wnt/β-Catenin Signaling and Tumor Burden in Colon Cancer
PLoS ONE, 6
(2007)
Vitamin D: molecular mechanism of action
J. Kong, Fangxiu Xu, J. Qu, Yu Wang, Ming Gao, Herbert Yu, B. Qian (2014)
Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival
Oncotarget, 6
L. Adorini, G. Penna, S. Amuchastegui, C. Cossetti, Francesca Aquilano, R. Mariani, B. Fibbi, A. Morelli, M. Uskoković, E. Colli, M. Maggi (2007)
Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol)
The Journal of Steroid Biochemistry and Molecular Biology, 103
Yan Li, M. Bolt, Li-Ping Cao, M. Sitrin (2001)
Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism.
American journal of physiology. Endocrinology and metabolism, 281 3
Rajiv Chowdhury, S. Kunutsor, A. Vitezova, C. Oliver‐Williams, S. Chowdhury, J. Kiefte-de-Jong, H. Khan, Cristina Baena, D. Prabhakaran, M. Hoshen, B. Feldman, A. Pan, Laura Johnson, F. Crowe, F. Hu, O. Franco (2014)
Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies
The BMJ, 348
R. Margolis, S. Christakos (2010)
The nuclear receptor superfamily of steroid hormones and vitamin D gene regulation
Annals of the New York Academy of Sciences, 1192
J. Geleijnse (2011)
Vitamin D and the prevention of hypertension and cardiovascular diseases: a review of the current evidence.
American journal of hypertension, 24 3
Sungtae Kim, M. Yamazaki, Lee Zella, N. Shevde, J. Pike (2006)
Activation of Receptor Activator of NF-κB Ligand Gene Expression by 1,25-Dihydroxyvitamin D3 Is Mediated through Multiple Long-Range Enhancers
Molecular and Cellular Biology, 26
E. Guallar, E. Miller, J. Ordovás, S. Stranges (2010)
Vitamin D Supplementation in the Age of Lost Innocence
Annals of Internal Medicine, 152
T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. Gillespie, T. Martin (1999)
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
Endocrine reviews, 20 3
Igor Orlov, N. Rochel, D. Moras, B. Klaholz (2012)
Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
The EMBO Journal, 31
N. Lopes, B. Sousa, D. Martins, Madalena Gomes, D. Vieira, L. Veronese, F. Milanezi, J. Paredes, J. Costa, F. Schmitt (2010)
Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions
BMC Cancer, 10
L. Lieben, R. Masuyama, R. Masuyama, S. Torrekens, R. Looveren, J. Schrooten, P. Baatsen, M. Lafage-Proust, T. Dresselaers, Jian Feng, L. Bonewald, M. Meyer, J. Pike, R. Bouillon, G. Carmeliet (2012)
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization.
The Journal of clinical investigation, 122 5
Dare Ajibade, P. Dhawan, A. Fechner, M. Meyer, J. Pike, S. Christakos (2010)
Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin.
Endocrinology, 151 7
N. Ding, R. Yu, N. Subramaniam, M. Sherman, Caroline Wilson, Renuka Rao, Mathias Leblanc, Sally Coulter, Mingxiao He, Christopher Scott, S. Lau, A. Atkins, G. Barish, J. Gunton, C. Liddle, M. Downes, R. Evans (2013)
A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
Cell, 153
M. Cantorna, Kaitlin McDaniel, S. Bora, Jing Chen, Jamaal James (2014)
Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
Experimental Biology and Medicine, 239
John White (2010)
Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future
The Journal of Steroid Biochemistry and Molecular Biology, 121
Qing Dong, W. Miller (2004)
Vitamin D 25-hydroxylase deficiency.
Molecular genetics and metabolism, 83 1-2
S. Lee, Kathleen Bishop, J. Goellner, C. O’Brien, J. Pike (2014)
Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype.
Endocrinology, 155 6
S. Syal, A. Kapoor, E. Bhatia, A. Sinha, Sudeep Kumar, S. Tewari, N. Garg, P. Goel (2012)
Vitamin D deficiency, coronary artery disease, and endothelial dysfunction: observations from a coronary angiographic study in Indian patients.
The Journal of invasive cardiology, 24 8
K. Martin, E. González, M. Gellens, L. Hamm, H. Abboud, J. Lindberg (1998)
19-Nor-1-alpha-25-dihydroxyvitamin D2 (Paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis.
Journal of the American Society of Nephrology : JASN, 9 8
Yurong Song, Xiaorong Peng, A. Porta, H. Takanaga, Ji-Bin Peng, M. Hediger, J. Fleet, S. Christakos (2003)
Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice.
Endocrinology, 144 9
M. Cippitelli, A. Santoni (1998)
Vitamin D3: a transcriptional modulator of the interferon-gamma gene.
European journal of immunology, 28 10
A. Tse, Guo‐Yuan Zhu, Chi-Keung Wan, Xiao-Ling Shen, Zhi-Ling Yu, W. Fong (2010)
1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells.
Molecular immunology, 47 9
J. So, HongJin Lee, Amanda Smolarek, Shiby Paul, Chung-Xiou Wang, H. Maehr, M. Uskoković, Xi Zheng, A. Conney, Li Cai, Fang Liu, N. Suh (2011)
A Novel Gemini Vitamin D Analog Represses the Expression of a Stem Cell Marker CD44 in Breast Cancer
Molecular Pharmacology, 79
S. Takeda, T. Yoshizawa, Y. Nagai, H. Yamato, S. Fukumoto, Keisuke Sekline, S. Kato, T. Matsumoto, T. Fujita (1999)
Stimulation of Osteoclast Formation by 1,25-Dihydroxyvitamin D Requires Its Binding to Vitamin D Receptor (VDR) in Osteoblastic Cells: Studies Using VDR Knockout Mice.
Endocrinology, 140 2
Hiroki Fujita, K. Sugimoto, Shuichiro Inatomi, Toshihiro Maeda, M. Osanai, Y. Uchiyama, Yoko Yamamoto, T. Wada, T. Kojima, H. Yokozaki, T. Yamashita, S. Kato, N. Sawada, H. Chiba (2008)
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.
Molecular biology of the cell, 19 5
D. Panda, D. Miao, M. Tremblay, J. Sirois, R. Farookhi, G. Hendy, D. Goltzman (2001)
Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction
Proceedings of the National Academy of Sciences of the United States of America, 98
M. Raval-Pandya, P. Dhawan, Frank Barletta, Sylvia Christakos (2001)
YY1 represses vitamin D receptor-mediated 25-hydroxyvitamin D(3)24-hydroxylase transcription: relief of repression by CREB-binding protein.
Molecular endocrinology, 15 6
L. Esteban, M. Vidal, A. Dusso (2004)
1alpha-Hydroxylase transactivation by gamma-interferon in murine macrophages requires enhanced C/EBPbeta expression and activation.
The Journal of steroid biochemistry and molecular biology, 89-90 1-5
M. Song, Reiko Nishihara, Molin Wang, A. Chan, Z. Qian, K. Inamura, Xuehong Zhang, K. Ng, S. Kim, K. Mima, Y. Sukawa, K. Nosho, C. Fuchs, E. Giovannucci, K. Wu, S. Ogino (2015)
Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status
Gut, 65
V. González-Pardo, A. Suares, A. Verstuyf, P. Clercq, R. Boland, A. Boland (2014)
Cell cycle arrest and apoptosis induced by 1α,25(OH)2D3 and TX 527 in Kaposi sarcoma is VDR dependent
The Journal of Steroid Biochemistry and Molecular Biology, 144
M. Meyer, N. Benkusky, Chang-Hun Lee, J. Pike (2014)
Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell Differentiation*♦
The Journal of Biological Chemistry, 289
F. Ciesielski, N. Rochel, D. Moras (2007)
Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: Remodelling the LBP with one side chain rotation
The Journal of Steroid Biochemistry and Molecular Biology, 103
C. Milani, Maria Lucia, Hirata Katayama, Eduardo Lyra, J. Welsh, Laura Campos, M. Brentani, Maria Do, Socorro Maciel, Rosimeire Roela, Paulo Valle, João Carlos, Guedes Góes, S. Nonogaki, Rodrigo Tamura, Maria Azevedo, Koike Folgueira (2013)
Transcriptional effects of 1,25 dihydroxyvitamin D3 physiological and supra-physiological concentrations in breast cancer organotypic culture
BMC Cancer, 13
M. Cippitelli, A. Santoni (1998)
Vitamin D3: a transcriptional modulator of the interferon‐γ gene
European Journal of Immunology, 28
Galina Kutuzova, H. DeLuca (2004)
Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties
Archives of Biochemistry and Biophysics, 432
S. Kunutsor, T. Apekey, M. Steur (2013)
Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants
European Journal of Epidemiology, 28
Jot Ooi, Kaitlin McDaniel, Veronika Weaver, M. Cantorna (2014)
Murine CD8+ T cells but not macrophages express the vitamin D 1α-hydroxylase.
The Journal of nutritional biochemistry, 25 1
S. Attia, J. Eickhoff, G. Wilding, D. McNeel, J. Blank, H. Ahuja, A. Jumonville, M. Eastman, D. Shevrin, M. Glodé, D. Alberti, M. Staab, D. Horvath, J. Straus, R. Marnocha, Glenn Liu (2008)
Randomized, Double-Blinded Phase II Evaluation of Docetaxel with or without Doxercalciferol in Patients with Metastatic, Androgen-Independent Prostate Cancer
Clinical Cancer Research, 14
J. Zhang, Z. Yao (2000)
Effect of 1,25(OH)2D3 on the growth and apoptosis of breast cancer cell line MCF-7.
Chinese medical journal, 113 2
P. Broulík, K. Horký, V. Pacovský (1986)
Effect of Parathyroid Hormone on Plasma Renin Activity in Humans
Horm. metabol. Res., 18
S. Kitanaka, K. Takeyama, A. Murayama, Takashi Sato, Katsuzumi Okumura, Masahiro Nogami, Yukihiro Hasegawa, Hiroo Niimi, Junn Yanagisawa, Toshiaki Tanaka, Shigeaki Kato (1998)
Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets.
The New England journal of medicine, 338 10
E. Tokar, M. Webber (2005)
Cholecalciferol (Vitamin D3) Inhibits Growth and Invasion by Up-regulating Nuclear Receptors and 25-Hydroxylase (CYP27A1) in Human Prostate Cancer Cells
Clinical & Experimental Metastasis, 22
G. Eelen, L. Verlinden, N. Rochel, F. Claessens, P. Clercq, M. Vandewalle, G. Tocchini-Valentini, D. Moras, R. Bouillon, A. Verstuyf (2005)
Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
Molecular Pharmacology, 67
M. Friedrich, L. Rafi, T. Mitschele, W. Tilgen, W. Schmidt, J. Reichrath (2003)
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 164
Yoshihiko Ohyama, M. Noshiro, Goesta Eggertsen, Osamu Gotoh, Yukio Kato, I. Bjoerkhem, Kyuichiro Okuda (1993)
Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase.
Biochemistry, 32 1
J. Frazão, L. Elangovan, H. Maung, R. Chesney, S. Acchiardo, J. Bower, B. Kelley, H. Rodriguez, Keith Norris, J. Robertson, B. Levine, W. Goodman, D. Gentile, R. Mazess, D. Kyllo, L. Douglass, C. Bishop, J. Coburn (2000)
Intermittent doxercalciferol (1α-Hydroxyvitamin D2) therapy for secondary hyperparathyroidism
American Journal of Kidney Diseases, 36
B. Guo, F. Aslam, A. Wijnen, S. Roberts, B. Frenkel, M. Green, H. DeLuca, J. Lian, G. Stein, J. Stein (1997)
YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene.
Proceedings of the National Academy of Sciences of the United States of America, 94 1
L. Crofts, M. Hancock, N. Morrison, J. Eisman (1998)
Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts.
Proceedings of the National Academy of Sciences of the United States of America, 95 18
R. Erben, D. Soegiarto, K. Weber, Ute Zeitz, M. Lieberherr, R. Gniadecki, G. Möller, J. Adamski, R. Balling (2002)
Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.
Molecular endocrinology, 16 7
B. Bao, S. Yeh, Yi-Fen Lee (2005)
1α,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases
Carcinogenesis, 27
R. Heaney, R. Horst, D. Cullen, L. Armas (2009)
Vitamin D3 Distribution and Status in the Body
Journal of the American College of Nutrition, 28
Louise Beveridge, A. Struthers, F. Khan, R. Jorde, R. Scragg, H. Macdonald, J. Alvarez, R. Boxer, A. Dalbeni, Adam Gepner, N. Isbel, Thomas Larsen, J. Nagpal, W. Petchey, H. Stricker, F. Strobel, V. Tangpricha, L. Toxqui, M. Vaquero, L. Wamberg, A. Zittermann, M. Witham (2015)
Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data.
JAMA internal medicine, 175 5
H. Cross, R. Corradino, M. Peterlik (1987)
Calcitriol-dependent, paracellular sodium transport in the embryonic chick intestine
Molecular and Cellular Endocrinology, 53
M. Høyer-Hansen, L. Bastholm, I. Mathiasen, F. Elling, M. Jäättelä (2005)
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
Cell Death and Differentiation, 12
H. Ting, James Messing, S. Yasmin-Karim, Yi-Fen Lee (2012)
Identification of microRNA-98 as a Therapeutic Target Inhibiting Prostate Cancer Growth and a Biomarker Induced by Vitamin D
The Journal of Biological Chemistry, 288
Glenville Jones, D. Prosser, M. Kaufmann (2014)
Cytochrome P450-mediated metabolism of vitamin D
Journal of Lipid Research, 55
E. Sato-Deguchi, Shinichi Imafuku, Bin Chou, K. Ishii, Kenji Hiromatsu, Juichiro Nakayama (2012)
Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
British Journal of Dermatology, 167
J. Pike, M. Meyer (2012)
Regulation of mouse Cyp24a1 expression via promoter-proximal and downstream-distal enhancers highlights new concepts of 1,25-dihydroxyvitamin D(3) action.
Archives of biochemistry and biophysics, 523 1
P. Singh, M. Long, S. Battaglia, Q. Hu, Song Liu, Lara Sucheston-Campbell, M. Campbell (2015)
VDR regulation of microRNA differs across prostate cell models suggesting extremely flexible control of transcription
Epigenetics, 10
T. Matkovits, S. Christakos (1995)
Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca,Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors.
Endocrinology, 136 9
B. Novaković, M. Sibson, H. Ng, U. Manuelpillai, V. Rakyan, T. Down, S. Beck, T. Fournier, D. Evain-Brion, E. Dimitriadis, J. Craig, R. Morley, R. Saffery (2009)
Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene
The Journal of Biological Chemistry, 284
Glenville Jones, D. Prosser, M. Kaufmann (2012)
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.
Archives of biochemistry and biophysics, 523 1
S. Rosli, T. Shintani, S. Toratani, E. Usui, T. Okamoto (2014)
1α,25(OH)2D3 inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1
In Vitro Cellular & Developmental Biology - Animal, 50
Shaoping Wu, Yongguo Zhang, Rong Lu, Yinglin Xia, David Zhou, E. Petrof, E. Claud, Di Chen, E. Chang, G. Carmeliet, Jun Sun (2014)
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis
Gut, 64
M. Demay, M. Kiernan, H. DeLuca, H. Kronenberg (1992)
Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.
Proceedings of the National Academy of Sciences of the United States of America, 89 17
P. Malloy, J. Pike, D. Feldman (1999)
The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets.
Endocrine reviews, 20 2
H. Wilson, H. Schedl (1983)
Rat large bowel maintains calcium transport after small bowel resection.
Digestion, 26 4
F. Mattner, S. Smiroldo, F. Galbiati, M. Muller, Pietro Lucia, P. Poliani, G. Martino, P. Panina-Bordignon, L. Adorini (2000)
Inhibition of Th1 development and treatment of chronic‐relapsing experimental allergic encephalomyelitis by a non‐hypercalcemic analogue of 1,25‐dihydroxyvitamin D3
European Journal of Immunology, 30
K. Koli, Jorma Keski-oja (2000)
1alpha,25-dihydroxyvitamin D3 and its analogues down-regulate cell invasion-associated proteases in cultured malignant cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 11 4
S. Pilz, A. Tomaschitz, E. Ritz, T. Pieber (2009)
Vitamin D status and arterial hypertension: a systematic review
Nature Reviews Cardiology, 6
T. Gulliford, J. English, K. Colston, P. Menday, S. Møller, R. Coombes (1998)
A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer.
British Journal of Cancer, 78
C. Zierold, J. Nehring, H. DeLuca (2007)
Nuclear receptor 4A2 and C/EBPβ regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1α-hydroxylase
Archives of Biochemistry and Biophysics, 460
M. Favus, E. Angeid-Backman (1985)
Effects of 1,25(OH)2D3 and calcium channel blockers on cecal calcium transport in the rat.
The American journal of physiology, 248 6 Pt 1
Q. Shen, S. Christakos (2005)
The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin*
Journal of Biological Chemistry, 280
Jinge Zhu, H. DeLuca (2012)
Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?
Archives of biochemistry and biophysics, 523 1
E. Giovannucci, Yan Liu, B. Hollis, E. Rimm (2008)
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.
Archives of internal medicine, 168 11
Shiguang Liu, Wen Tang, Jianping Zhou, Jason Stubbs, Q. Luo, Min Pi, L. Quarles (2006)
Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.
Journal of the American Society of Nephrology : JASN, 17 5
Silvia Álvarez-Díaz, Noelia Valle, Gemma Ferrer-Mayorga, L. Lombardía, M. Herrera, O. Domínguez, M. Segura, F. Bonilla, E. Hernando, A. Muñoz (2012)
MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.
Human molecular genetics, 21 10
M. Griffin, W. Lutz, V. Phan, L. Bachman, D. McKean, R. Kumar (2001)
Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 98 12
Angham Mutair, Ghada Nasrat, D. Russell (2012)
Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency.
The Journal of clinical endocrinology and metabolism, 97 10
Alison MacLeod (2009)
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
Kidney International, 76
Jackie Fretz, Lee Zella, Sungtae Kim, N. Shevde, J. Pike (2006)
1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription.
Molecular endocrinology, 20 9
C. Mathieu, M. Waer, J. Laureys, O. Rutgeerts, R. Bouillon (1994)
Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3
Diabetologia, 37
Natasha Ryz, Scott Patterson, Yiqun Zhang, Caixia Ma, Tina Huang, G. Bhinder, Xiujuan Wu, J. Chan, Alexa Glesby, H. Sham, J. Dutz, M. Levings, K. Jacobson, B. Vallance (2012)
Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.
American journal of physiology. Gastrointestinal and liver physiology, 303 12
M. Meyer, N. Benkusky, J. Pike (2015)
Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions*
The Journal of Biological Chemistry, 290
G. Schwartz, M. Hall, D. Stindt, S. Patton, J. Lovato, F. Torti (2005)
Phase I/II Study of 19-nor-1α-25-Dihydroxyvitamin D2 (Paricalcitol) in Advanced, Androgen-Insensitive Prostate Cancer
Clinical Cancer Research, 11
H. Maung, L. Elangovan, J. Frazão, J. Bower, B. Kelley, S. Acchiardo, H. Rodriguez, Keith Norris, J. Sigala, M. Rutkowski, J. Robertson, W. Goodman, B. Levine, R. Chesney, R. Mazess, D. Kyllo, L. Douglass, C. Bishop, J. Coburn (2001)
Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D(2)) in dialysis patients with secondary hyperparathyroidism: a sequential comparison.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 37 3
Els Vanoirbeek, G. Eelen, L. Verlinden, G. Carmeliet, Chantal Mathieu, R. Bouillon, Rosemary O'Connor, Gutian Xiao, A. Verstuyf (2014)
PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D
Oncogene, 33
(1997)
Analog metabolism
C. Narvaez, Donald Matthews, E. LaPorta, Katrina Simmons, Sarah Beaudin, J. Welsh (2014)
The impact of vitamin D in breast cancer: genomics, pathways, metabolism
Frontiers in Physiology, 5
J. Coburn, H. Maung, L. Elangovan, M. Germain, J. Lindberg, S. Sprague, Mark Williams, C. Bishop (2004)
Doxercalciferol safely suppresses PTH levels in patients with secondary hyperparathyroidism associated with chronic kidney disease stages 3 and 4.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 43 5
K. White, W. Evans, J. O'Riordan, M. Speer, M. Econs, B. Lorenz-Depiereux, M. Grabowski, T. Meitinger, T. Strom (2000)
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
Nature Genetics, 26
M. Washington, N. Weigel (2010)
1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion.
Endocrinology, 151 4
G. Barbour, J. Coburn, E. Slatopolsky, A. Norman, R. Horst (1981)
Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D.
The New England journal of medicine, 305 8
P. Lips, E. Gielen, N. Schoor (2014)
Vitamin D supplements with or without calcium to prevent fractures.
BoneKEy reports, 3
M. Mann, Amy Hobbs, B. Hemmelgarn, D. Roberts, Sofia Ahmed, D. Rabi (2014)
Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis
Clinical Kidney Journal, 8
J. Hoenderop, J. Leeuwen, B. Eerden, Ferry Kersten, A. Kemp, A. Mérillat, J. Waarsing, B. Rossier, V. Vallon, E. Hummler, R. Bindels (2003)
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.
The Journal of clinical investigation, 112 12
Sneha Joshi, Luiz Pantalena, Xikui Liu, S. Gaffen, Hong Liu, C. Rohowsky-Kochan, K. Ichiyama, A. Yoshimura, L. Steinman, S. Christakos, S. Youssef (2011)
25-Dihydroxyvitamin D 3 Ameliorates Th 17 Autoimmunity via Transcriptional Modulation of Interleukin-17 A
Jacqueline Moreno, A. Krishnan, S. Swami, L. Nonn, D. Peehl, D. Feldman (2005)
Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells.
Cancer research, 65 17
H. Joist, S. Ahya, K. Giles, K. Norwood, E. Slatopolsky, D. Coyne (2006)
Differential effects of very high doses of doxercalciferol and paricalcitol on serum phosphorus in hemodialysis patients.
Clinical nephrology, 65 5
A. Parfitt, C. Mathews, R. Brommage, K. Jarnagin, H. DeLuca (1984)
Calcitriol but no other metabolite of vitamin D is essential for normal bone growth and development in the rat.
The Journal of clinical investigation, 73 2
D. Albertson, B. Ylstra, R. Segraves, C. Collins, S. Dairkee, D. Kowbel, W. Kuo, J. Gray, D. Pinkel (2000)
Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
Nature Genetics, 25
R. Wood, J. Fleet, K. Cashman, M. Bruns, H. DeLuca (1998)
Intestinal calcium absorption in the aged rat: evidence of intestinal resistance to 1,25(OH)2 vitamin D.
Endocrinology, 139 9
Wyatt Messenger, C. Nielson, H. Li, Tomasz Beer, E. Barrett-Connor, K. Stone, J. Shannon (2012)
Serum and dietary vitamin D and cardiovascular disease risk in elderly men: a prospective cohort study.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 22 10
B. Hollis, D. Bikle (2014)
Vitamin D-binding protein and vitamin D in blacks and whites.
The New England journal of medicine, 370 9
J. Höbaus, U. Thiem, Doris Hummel, E. Kallay (2012)
Role of calcium, vitamin D, and the extrarenal vitamin D hydroxylases in carcinogenesis.
Anti-cancer agents in medicinal chemistry, 13 1
Hironori Yamamoto, N. Shevde, Anjali Warrier, L. Plum, H. DeLuca, J. Pike (2003)
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts*
Journal of Biological Chemistry, 278
Simon Jensen, M. Madsen, J. Lukas, L. Binderup, J. Bartek (2001)
Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery.
Molecular endocrinology, 15 8
L. Trémezaygues, J. Reichrath (2011)
Vitamin D analogs in the treatment of psoriasis
Dermato-Endocrinology, 3
ABDUL GAFOR, Rashidi Saidin, C. Loo, R. Mohd, Soehardy Zainudin, S. Shah, KONG Norella (2009)
Intravenous calcitriol versus paricalcitol in haemodialysis patients with severe secondary hyperparathyroidism
Nephrology, 14
Wendy Unger, S. Laban, F. Kleijwegt, A. Slik, B. Roep (2009)
Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1
European Journal of Immunology, 39
D. Feldman, Peter Malloy (2014)
Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets.
BoneKEy reports, 3
H. Pálmer, J. González-Sancho, J. Espada, M. Berciano, I. Puig, J. Baulida, M. Quintanilla, A. Cano, A. Herreros, M. Lafarga, A. Muñoz (2001)
Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
The Journal of Cell Biology, 154
G. Bergh, A. Telléus, A. Fritzon, S. Kornfält, E. Johnson, I. Olsson, U. Gullberg (2001)
Forced expression of the cyclin-dependent kinase inhibitor p16(INK4A) in leukemic U-937 cells reveals dissociation between cell cycle and differentiation.
Experimental hematology, 29 12
U. Karbach (1992)
Paracellular calcium transport across the small intestine.
The Journal of nutrition, 122 3 Suppl
M. Thill, S. Becker, D. Fischer, T. Cordes, A. Hornemann, K. Diedrich, D. Salehin, M. Friedrich (2009)
Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells.
Anticancer research, 29 9
J. Gee, H. Bailey, KyungMann Kim, J. Kolesar, T. Havighurst, K. Tutsch, W. See, Michael Cohen, N. Street, Leon Levan, D. Jarrard, G. Wilding (2013)
Phase II open label, multi‐center clinical trial of modulation of intermediate endpoint biomarkers by 1α‐hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
The Prostate, 73
S. Judd, M. Nanes, T. Ziegler, P. Wilson, V. Tangpricha (2008)
Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.
The American journal of clinical nutrition, 87 1
J. Lee, Haojie Li, A. Chan, B. Hollis, I. Lee, M. Stampfer, K. Wu, E. Giovannucci, Jing Ma (2011)
Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
Cancer Prevention Research, 4
E. Jacobs, C. Pelt, Ryan Forster, Wasiq Zaidi, Elizabeth Hibler, M. Galligan, M. Haussler, P. Jurutka (2013)
CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells.
Cancer research, 73 8
A. Halteren, E. Etten, E. Jong, R. Bouillon, B. Roep, C. Mathieu (2002)
Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).
Diabetes, 51 7
Takuya Mohri, M. Nakajima, S. Takagi, Sayaka Komagata, T. Yokoi (2009)
MicroRNA regulates human vitamin D receptor
International Journal of Cancer, 125
O. Mayer (2012)
[Vitamin D and cardiovascular risk].
Vnitrni lekarstvi, 58 5
Y. Li, M. Amling, M. Amling, A. Pirro, M. Priemel, Jennifer Meuse, R. Baron, G. Delling, M. Demay (1998)
Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice1
Endocrinology, 139
Satoshi Kondo, Toshiyuki Takano, Y. Ono, H. Saito, Toshio Matsumoto (2015)
Eldecalcitol reduces osteoporotic fractures by unique mechanisms
The Journal of Steroid Biochemistry and Molecular Biology, 148
Jeffrey Cheng, M. Levine, N. Bell, D. Mangelsdorf, D. Russell (2004)
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.
Proceedings of the National Academy of Sciences of the United States of America, 101 20
O. Belochitski, S. Ariad, S. Shany, Vladimir Fridman, V. Gavrilov (2007)
Efficient dual treatment of the hormone-refractory prostate cancer cell line DU145 with cetuximab and 1,25-dihydroxyvitamin D3.
In vivo, 21 2
T. Takiishi, L. Ding, F. Baeke, I. Spagnuolo, G. Sebastiani, J. Laureys, A. Verstuyf, G. Carmeliet, F. Dotta, T. Belle, C. Gysemans, C. Mathieu (2014)
Dietary Supplementation With High Doses of Regular Vitamin D3 Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term
Diabetes, 63
L. Verlinden, G. Eelen, Ruth Hellemont, K. Engelen, Ine Beullens, M. Camp, K. Marchal, Chantal Mathieu, R. Bouillon, A. Verstuyf (2007)
1α,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130
The Journal of Steroid Biochemistry and Molecular Biology, 103
D. Min, Xiaobin Lv, Xiaolong Wang, Boyu Zhang, W. Meng, F. Yu, H. Hu (2013)
Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity
British Journal of Cancer, 109
M. Levine, A. Dang, C. Ding, P. Fischer, Ravinder Singh, T. Thacher (2007)
Tropical rickets in Nigeria: Mutation of the CYP2R1 gene encoding vitamin D 25-hydroxylase as a cause of vitamin D dependent rickets
Bone, 40
Rebecca Replogle, Qiang Li, Libo Wang, Min Zhang, J. Fleet (2014)
Gene‐by‐Diet Interactions Influence Calcium Absorption and Bone Density in Mice
Journal of Bone and Mineral Research, 29
N. Wagner, K. Wagner, G. Schley, L. Badiali, H. Theres, H. Scholz (2003)
1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax.
Experimental eye research, 77 1
J. Lawrence, S. Akman, S. Melin, L. Case, G. Schwartz (2013)
Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer
Cancer Biology & Therapy, 14
S. Gutiérrez, A. Javed, Daniel Tennant, Monique Rees, M. Montecino, G. Stein, J. Stein, J. Lian (2002)
CCAAT/Enhancer-binding Proteins (C/EBP) β and δ Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression*
The Journal of Biological Chemistry, 277
J. Adams, O. Sharma, M. Gacad, F. Singer (1983)
Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis.
The Journal of clinical investigation, 72 5
H. Newmark, Kan Yang, N. Kurihara, K. Fan, L. Augenlicht, M. Lipkin (2008)
Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer.
Carcinogenesis, 30 1
(2012)
Transgenic expression of the vitamin D receptor restricted to the ileum, cecum and colon of VDR knockout mice rescues VDR dependent rickets
S. Gregori, Nadia Giarratana, S. Smiroldo, M. Uskoković, L. Adorini (2002)
A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice.
Diabetes, 51 5
Y. Li, J. Kong, Minjie Wei, Zhoudao Chen, Shu Liu, Li-ping Cao (2002)
1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.
The Journal of clinical investigation, 110 2
T. Yoshizawa, Y. Handa, Y. Uematsu, S. Takeda, K. Sekine, Yuko Yoshihara, Toru Kawakami, Kouki Arioka, Hiroshi Sato, Y. Uchiyama, S. Masushige, A. Fukamizu, Toshio Matsumoto, S. Kato (1997)
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
Nature Genetics, 16
Kevin Martin, E. González, Mary Gellens, L. Hamm, Hanna Abboud, J. Lindberg (1998)
Therapy of secondary hyperparathyroidism with 19-nor-1alpha,25-dihydroxyvitamin D2.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 32 2 Suppl 2
S. Lee, J. Goellner, C. O’Brien, J. Pike (2014)
A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia.
Endocrinology, 155 11
G. Zinser, Kevin McEleney, J. Welsh (2003)
Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice
Molecular and Cellular Endocrinology, 200
J. Leipziger (2006)
Faculty Opinions recommendation of The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
S. Yim, P. Dhawan, C. Ragunath, S. Christakos, G. Diamond (2007)
Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3).
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 6 6
I. Mheid, R. Patel, R. Patel, J. Murrow, A. Morris, Ayaz Rahman, L. Fike, N. Kavtaradze, Irina Uphoff, C. Hooper, V. Tangpricha, R. Alexander, K. Brigham, K. Brigham, A. Quyyumi (2011)
Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.
Journal of the American College of Cardiology, 58 2
D. Coyne, D. Andress, M. Amdahl, E. Ritz, D. Zeeuw (2013)
Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy: results of the VITAL study
Nephrology Dialysis Transplantation, 28
C. Daniel, N. Sartory, Nadine Zahn, H. Radeke, J. Stein (2008)
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
Journal of Pharmacology and Experimental Therapeutics, 324
R. Alexander, Titia Woudenberg-Vrenken, J. Buurman, H. Dijkman, Bram Eerden, Johannes Leeuwen, René Bindels, J. Hoenderop (2009)
Klotho prevents renal calcium loss.
Journal of the American Society of Nephrology : JASN, 20 11
HongJin Lee, Shiby Paul, N. Atalla, P. Thomas, Xinjie Lin, I. Yang, B. Buckley, Gang Lu, Xi Zheng, Y. Lou, A. Conney, H. Maehr, L. Adorini, M. Uskoković, N. Suh (2008)
Gemini Vitamin D Analogues Inhibit Estrogen Receptor–Positive and Estrogen Receptor–Negative Mammary Tumorigenesis without Hypercalcemic Toxicity
Cancer Prevention Research, 1
Jinge Zhu, Justin Ochalek, M. Kaufmann, Glenville Jones, H. DeLuca (2013)
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
Proceedings of the National Academy of Sciences, 110
E. Hylander, K. Ladefoged, S. Jarnum (1990)
Calcium absorption after intestinal resection. The importance of a preserved colon.
Scandinavian journal of gastroenterology, 25 7
A. Pittas, M. Chung, T. Trikalinos, J. Mitri, M. Brendel, Kamal Patel, A. Lichtenstein, J. Lau, E. Balk (2010)
Systematic Review: Vitamin D and Cardiometabolic Outcomes
Annals of Internal Medicine, 152
Katie Evans, L. Nguyen, J. Chan, B. Innes, J. Bulmer, M. Kilby, M. Hewison (2006)
Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells1
, 75
S. Maund, W. Barclay, Laura Hover, Linara Axanova, Guangchao Sui, J. Hipp, J. Fleet, A. Thorburn, S. Cramer (2011)
Interleukin-1α mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells.
Cancer research, 71 15
R. Bouillon, H. Baelen, P. Moor (1980)
Comparative study of the affinity of the serum vitamin D-binding protein.
Journal of steroid biochemistry, 13 9
A. Cranney, T. Horsley, S. O'Donnell, H. Weiler, L. Puil, D. Ooi, S. Atkinson, L. Ward, D. Moher, D. Hanley, Manchun Fang, F. Yazdi, C. Garritty, M. Sampson, N. Barrowman, A. Tsertsvadze, V. Mamaladze (2007)
Effectiveness and safety of vitamin D in relation to bone health.
Evidence report/technology assessment, 158
K. Singarapu, Jinge Zhu, M. Tonelli, Hong-yu Rao, F. Assadi-Porter, W. Westler, H. DeLuca, J. Markley (2011)
Ligand-specific structural changes in the vitamin D receptor in solution.
Biochemistry, 50 51
Toshio Matsumoto, Masako Ito, Y. Hayashi, T. Hirota, Y. Tanigawara, T. Sone, M. Fukunaga, M. Shiraki, Toshitaka Nakamura (2011)
A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.
Bone, 49 4
Xuening Wang, G. Studzinski (1997)
Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c.
Experimental cell research, 235 1
P. Dhawan, Xiaorong Peng, A. Sutton, P. MacDonald, C. Croniger, C. Trautwein, M. Centrella, T. McCarthy, S. Christakos (2005)
Functional Cooperation between CCAAT/Enhancer-Binding Proteins and the Vitamin D Receptor in Regulation of 25-Hydroxyvitamin D3 24-Hydroxylase
Molecular and Cellular Biology, 25
Megan Donohue, M. Demay (2002)
Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes.
Endocrinology, 143 9
N. Kuchuk, S. Pluijm, N. Schoor, C. Looman, J. Smit, P. Lips (2009)
Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons.
The Journal of clinical endocrinology and metabolism, 94 4
T. Akizawa, T. Akiba, H. Hirakata, E. Kinugasa, Y. Tominaga, M. Fukagawa, K. Yokoyama, Wuyan Zhang, P. Linde, Masashi Suzuki (2015)
Comparison of Paricalcitol With Maxacalcitol Injection in Japanese Hemodialysis Patients With Secondary Hyperparathyroidism
Therapeutic Apheresis and Dialysis, 19
T. Shinki, Y. Ueno, H. DeLuca, T. Suda (1999)
Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha-hydroxylase gene in normocalcemic rats.
Proceedings of the National Academy of Sciences of the United States of America, 96 14
Cheng-Yuan Kao, Yin Chen, Philip Thai, S. Wachi, Fei Huang, Christy Kim, R. Harper, R. Wu (2004)
IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways1
The Journal of Immunology, 173
G. Penna, L. Adorini (2000)
1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation
The Journal of Immunology, 164
L. Canaff, G. Hendy (2002)
Human Calcium-sensing Receptor Gene
The Journal of Biological Chemistry, 277
B. Boyle, Xiao-yan Zhao, Pinchas Cohen, D. Feldman (2001)
Insulin-like growth factor binding protein-3 mediates 1 alpha,25-dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1.
The Journal of urology, 165 4
R. Thadhani, E. Appelbaum, Y. Pritchett, Yuchiao Chang, J. Wenger, Hector Tamez, I. Bhan, R. Agarwal, C. Zoccali, C. Wanner, D. Lloyd‐Jones, J. Cannata, B. Thompson, D. Andress, Wuyan Zhang, D. Packham, D. Packham, Bhupinder Singh, D. Zehnder, A. Shah, Ajay Pachika, Warren Manning, Scott Solomon (2012)
Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial.
JAMA, 307 7
A. Giangreco, Shweta Dambal, Dennis Wagner, T. Kwast, R. Vieth, G. Prins, L. Nonn (2015)
Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model
The Journal of Steroid Biochemistry and Molecular Biology, 148
N. Liu, Amber Kaplan, J. Low, L. Nguyen, George Liu, O. Equils, M. Hewison (2009)
Vitamin D Induces Innate Antibacterial Responses in Human Trophoblasts via an Intracrine Pathway1
, 80
A. Halteren, O. Tysma, E. Etten, C. Mathieu, B. Roep (2004)
1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis.
Journal of autoimmunity, 23 3
Songcang Chen, Christopher Law, Christopher Grigsby, Keith Olsen, T. Hong, Yan Zhang, Y. Yeghiazarians, D. Gardner (2011)
Cardiomyocyte-Specific Deletion of the Vitamin D Receptor Gene Results in Cardiac Hypertrophy
Circulation, 124
M. Kuro-o, Y. Matsumura, H. Aizawa, H. Kawaguchi, T. Suga, T. Utsugi, Y. Ohyama, M. Kurabayashi, T. Kaname, E. Kume, H. Iwasaki, A. Iida, T. Shiraki-Iida, S. Nishikawa, R. Nagai, Y. Nabeshima (1997)
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Nature, 390
Wei Zheng, Kari Wong, Zhongyi Zhang, Urzsula Dougherty, R. Mustafi, J. Kong, D. Deb, Huachuan Zheng, M. Bissonnette, Yan Li (2012)
Inactivation of the vitamin D receptor in APCmin/+ mice reveals a critical role for the vitamin D receptor in intestinal tumor growth
International Journal of Cancer, 130
D. Feldman, A. Krishnan, S. Swami, E. Giovannucci, B. Feldman (2014)
The role of vitamin D in reducing cancer risk and progression
Nature Reviews Cancer, 14
J. Cunningham, F. Locatelli, Mariano Rodríguez (2011)
Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options.
Clinical journal of the American Society of Nephrology : CJASN, 6 4
J. Barker, R. Ashton, R. Marks, R. Harris, J. Berth‐Jones (1999)
Topical maxacalcitol for the treatment of psoriasis vulgaris: a placebo‐controlled, double‐blind, dose‐finding study with active comparator
British Journal of Dermatology, 141
N. Rochel, F. Ciesielski, J. Godet, Edelmiro Moman, M. Roessle, C. Peluso‐Iltis, M. Moulin, M. Haertlein, P. Callow, Y. Mély, D. Svergun, D. Moras (2011)
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
Nature Structural &Molecular Biology, 18
R. Nerenz, Melissa Martowicz, J. Pike (2008)
An enhancer 20 kilobases upstream of the human receptor activator of nuclear factor-kappaB ligand gene mediates dominant activation by 1,25-dihydroxyvitamin D3.
Molecular endocrinology, 22 5
Terence McGuire, D. Trump, Candace Johnson (2001)
Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1.
The Journal of biological chemistry, 276 28
D. Iglesias-Gato, Shasha Zheng, J. Flanagan, Lan Jiang, A. Kittaka, T. Sakaki, Keiko Yamamoto, T. Itoh, N. LeBrasseur, G. Norstedt, Tai Chen (2011)
Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells
The Journal of Steroid Biochemistry and Molecular Biology, 127
T. Monkawa, Tadashi Yoshida, S. Wakino, T. Shinki, H. Anazawa, H. DeLuca, T. Suda, M. Hayashi, T. Saruta (1997)
Molecular Cloning of cDNA and Genomic DNA for Human 25-hydroxyvitamin D31α-hydroxylase
Biochemical and Biophysical Research Communications, 239
Yingyu Ma, Wei-dong Yu, D. Trump, Candace Johnson (2010)
1,25D3 Enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models
Cancer, 116
D. Bruce, J. Whitcomb, A. August, M. McDowell, M. Cantorna (2009)
Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice.
International immunology, 21 2
M. Priemel, C. Domarus, T. Klatte, Steffen Kessler, Julia Schlie, S. Meier, N. Proksch, F. Pastor, Clemens Netter, T. Streichert, K. Püschel, M. Amling (2010)
Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25‐hydroxyvitamin D in 675 patients
Journal of Bone and Mineral Research, 25
S. Essa, S. Reichrath, U. Mahlknecht, M. Montenarh, T. Vogt, J. Reichrath (2012)
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
Anticancer research, 32 1
L. Plum, H. DeLuca (2010)
Vitamin D, disease and therapeutic opportunities
Nature Reviews Drug Discovery, 9
K. Schlingmann, M. Kaufmann, S. Weber, Andrew Irwin, Caroline Goos, U. John, J. Misselwitz, G. Klaus, E. Kuwertz-Bröking, H. Fehrenbach, A. Wingen, T. Güran, J. Hoenderop, R. Bindels, D. Prosser, Glenville Jones, M. Konrad (2011)
Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
The New England journal of medicine, 365 5
Wei Zhang, T. Na, Guojin Wu, Haiyan Jing, Ji-Bin Peng (2010)
Down-regulation of Intestinal Apical Calcium Entry Channel TRPV6 by Ubiquitin E3 Ligase Nedd4-2*
The Journal of Biological Chemistry, 285
John McGrath, S. Saha, T. Burne, D. Eyles (2010)
A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
The Journal of Steroid Biochemistry and Molecular Biology, 121
M. Consiglio, Michele Destefanis, Deborah Morena, Valentina Foglizzo, Mattia Forneris, G. Pescarmona, F. Silvagno (2014)
The Vitamin D Receptor Inhibits the Respiratory Chain, Contributing to the Metabolic Switch that Is Essential for Cancer Cell Proliferation
PLoS ONE, 9
L. Jeffery, F. Burke, M. Mura, Yong Zheng, O. Qureshi, M. Hewison, L. Walker, D. Lammas, K. Raza, D. Sansom (2009)
1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP31
The Journal of Immunology, 183
B. Mahon, A. Wittke, Veronika Weaver, M. Cantorna (2003)
The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
Journal of Cellular Biochemistry, 89
D. Gkika, Y. Hsu, A. Kemp, S. Christakos, R. Bindels, J. Hoenderop (2006)
Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
Journal of the American Society of Nephrology : JASN, 17 11
Jing-wen Yin, Gang Wang (2014)
The Mediator complex: a master coordinator of transcription and cell lineage development
Development, 141
J. Xiong, M. Onal, R. Jilka, R. Weinstein, S. Manolagas, C. O’Brien (2011)
Matrix-embedded cells control osteoclast formation
Nature medicine, 17
P. Shaffer, D. McDonnell, D. Gewirth (2005)
Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.
Biochemistry, 44 7
P. Baldock, G. Thomas, J. Hodge, Sara Baker, U. Dressel, P. O’Loughlin, G. Nicholson, Kathy Briffa, J. Eisman, E. Gardiner (2006)
Vitamin D Action and Regulation of Bone Remodeling: Suppression of Osteoclastogenesis by the Mature Osteoblast
Journal of Bone and Mineral Research, 21
K. White, K. White, G. Carn, G. Carn, B. Lorenz-Depiereux, B. Lorenz-Depiereux, A. Benet-Pagès, A. Benet-Pagès, T. Strom, T. Strom, Michael Econs, Michael Econs (2001)
Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23.
Kidney international, 60 6
Kamboh Mi, Robert Ferrell (1986)
Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations
Human Genetics, 72
N. Rochel, J. Wurtz, A. Mitschler, B. Klaholz, D. Moras (2000)
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.
Molecular cell, 5 1
Lee Zella, Sungtae Kim, N. Shevde, J. Pike (2006)
Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3.
Molecular endocrinology, 20 6
W. Park, J. Seol, E. Kim, C. Jung, C. Lee, L. Binderup, H. Koeffler, B. Kim, Y. Lee (2000)
Cell cycle arrest induced by the vitamin D(3) analog EB1089 in NCI-H929 myeloma cells is associated with induction of the cyclin-dependent kinase inhibitor p27.
Experimental cell research, 254 2
稲富周一郎 (2009)
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca[2+] absorption between enterocytes
K. Aihara, H. Azuma, M. Akaike, Yasumasa Ikeda, Michiko Yamashita, T. Sudo, H. Hayashi, Yoshihisa Yamada, Fuminari Endoh, M. Fujimura, Tomonori Yoshida, H. Yamaguchi, Shunji Hashizume, Midori Kato, Kimihiro Yoshimura, Yoko Yamamoto, S. Kato, Toshio Matsumoto (2004)
Disruption of Nuclear Vitamin D Receptor Gene Causes Enhanced Thrombogenicity in Mice*
Journal of Biological Chemistry, 279
H. Ogata, F. Koiwa, K. Shishido, Keiko Takahashi, Hidetoshi Ito, E. Kinugasa, S. Taguchi (2007)
Effects of 22‐Oxacalcitriol and Calcitriol on PTH Secretion and Bone Mineral Metabolism in a Crossover Trial in Hemodialysis Patients With Secondary Hyperparathyroidism
Therapeutic Apheresis and Dialysis, 11
H. Bischoff-Ferrari, W. Willett, E. Orav, P. Lips, P. Meunier, R. Lyons, L. Flicker, J. Wark, R. Jackson, J. Cauley, H. Meyer, M. Pfeifer, K. Sanders, H. Stähelin, R. Theiler, B. Dawson-Hughes (2012)
A pooled analysis of vitamin D dose requirements for fracture prevention.
The New England journal of medicine, 367 1
R. Masuyama, I. Stockmans, S. Torrekens, R. Looveren, C. Maes, P. Carmeliet, R. Bouillon, G. Carmeliet (2006)
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF 23 production in osteoblasts
1 Alpha , 25dihydroxyvitamin D 3 inhibits
A. Schafer, C. Weaver, D. Black, A. Wheeler, Hanling Chang, Gina Szefc, L. Stewart, S. Rogers, J. Carter, A. Posselt, D. Shoback, D. Sellmeyer (2015)
Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status
Journal of Bone and Mineral Research, 30
Minh Nguyen, Arnold d'Alésio, J. Pascussi, R. Kumar, M. Griffin, Xiang-yang Dong, H. Guillozo, M. Rizk-Rabin, C. Sinding, P. Bougnères, F. Jehan, M. Garabédian (2006)
Vitamin D–Resistant Rickets and Type 1 Diabetes in a Child With Compound Heterozygous Mutations of the Vitamin D Receptor (L263R and R391S): Dissociated Responses of the CYP‐24 and rel‐B Promoters to 1,25‐Dihydroxyvitamin D3
Journal of Bone and Mineral Research, 21
A. Gombart, N. Borregaard, H. Koeffler (2005)
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3
The FASEB Journal, 19
M. Cantorna, J. Humpal-Winter, H. DeLuca (1999)
Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice.
The Journal of nutrition, 129 11
Ming Chen, Alberto Perez, Deepak Sanan, Gerhard Heinrich, Tai-Chia Chen, Michael Holick (1996)
Induction of vitamin D receptor mRNA expression in psoriatic plaques correlates with clinical response to 1,25-dihydroxyvitamin D3.
The Journal of investigative dermatology, 106 4
Xuening Wang, Elżbieta Gocek, Changfeng Liu, G. Studzinski (2009)
MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3
Cell Cycle, 8
J. Manson, S. Bassuk, I. Lee, N. Cook, Michelle Albert, David Gordon, Elaine Zaharris, Jean Macfadyen, E. Danielson, Jennifer Lin, Shumin Zhang, J. Buring (2012)
The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease.
Contemporary clinical trials, 33 1

Publisher: Unpaywall
ISSN: 0031-9333
DOI: 10.1152/physrev.00014.2015
Publisher site: See Article on Publisher Site

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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects

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