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Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

Nuclear lamins: major factors in the structural organization and function of the nucleus and... Downloaded from genesdev.cshlp.org on September 20, 2021 - Published by Cold Spring Harbor Laboratory Press REVIEW Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin Thomas Dechat, Katrin Pfleghaar, Kaushik Sengupta, Takeshi Shimi, Dale K. Shumaker, Liliana Solimando, and Robert D. Goldman Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA Over the past few years it has become evident that the by numerous lamin-binding proteins (Dorner et al. 2007; intermediate filament proteins, the types A and B Schirmer and Foisner 2007; Wagner and Krohne 2007). nuclear lamins, not only provide a structural framework This review focuses on the role of nuclear lamins in for the nucleus, but are also essential for many aspects of the organization and regulation of chromatin in the in- normal nuclear function. Insights into lamin-related terphase nucleus—specifically, the involvement of lam- functions have been derived from studies of the remark- ins in essential processes such as transcription, DNA ably large number of disease-causing mutations in the replication, DNA repair, and various epigenetic phenom- human lamin A gene. This review provides an up-to-date ena involved in the regulation of euchromatin–hetero- overview of the functions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

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References (271)

Publisher
Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1652708
Publisher site
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Abstract

Downloaded from genesdev.cshlp.org on September 20, 2021 - Published by Cold Spring Harbor Laboratory Press REVIEW Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin Thomas Dechat, Katrin Pfleghaar, Kaushik Sengupta, Takeshi Shimi, Dale K. Shumaker, Liliana Solimando, and Robert D. Goldman Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA Over the past few years it has become evident that the by numerous lamin-binding proteins (Dorner et al. 2007; intermediate filament proteins, the types A and B Schirmer and Foisner 2007; Wagner and Krohne 2007). nuclear lamins, not only provide a structural framework This review focuses on the role of nuclear lamins in for the nucleus, but are also essential for many aspects of the organization and regulation of chromatin in the in- normal nuclear function. Insights into lamin-related terphase nucleus—specifically, the involvement of lam- functions have been derived from studies of the remark- ins in essential processes such as transcription, DNA ably large number of disease-causing mutations in the replication, DNA repair, and various epigenetic phenom- human lamin A gene. This review provides an up-to-date ena involved in the regulation of euchromatin–hetero- overview of the functions

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Genes & Development – Unpaywall

Published: Apr 1, 2008

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