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Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: A systematic review of the published literature with subgroup analysis

Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck... Background A systematic review was conducted to develop clinical recommendations for concomitant chemotherapy (CT) and radiotherapy (RT) in patients with locally advanced squamous cell head and neck cancer (SCHNC). Methods Results of published randomized controlled trials (RCTs) were pooled using Meta‐analyst0.988 software. Results A pooled analysis of 18 RCTs (20 comparisons) involving 3,192 patients detected a reduction in mortality for concomitant therapy compared with RT alone (odds ratio (OR), 0.62; 95% confidence interval (CI), 0.52–0.74; relative risk, 0.83; risk reduction, 11%; p < .00001). Platinum‐based regimens involving 1,514 patients from nine trials (10 comparisons) were most effective (OR, 0.57; 95% CI, 0.46–0.71; p < .00001; risk reduction, 12%). Concomitant therapy produced more acute adverse effects than RT alone. Conclusion Platinum‐based concomitant CT and RT is superior to conventional RT alone in improving survival in locally advanced SCHNC. Subgroup analyses can be used to help in choosing the most appropriate concomitant regimen. © 2001 John Wiley & Sons, Inc. Head Neck 23: 579–589, 2001. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Head & Neck: Journal for the Sciences & Specialties of the Head and Neck Wiley

Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: A systematic review of the published literature with subgroup analysis

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References (55)

Publisher
Wiley
Copyright
Copyright © 2001 John Wiley & Sons, Inc.
ISSN
1043-3074
eISSN
1097-0347
DOI
10.1002/hed.1081
Publisher site
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Abstract

Background A systematic review was conducted to develop clinical recommendations for concomitant chemotherapy (CT) and radiotherapy (RT) in patients with locally advanced squamous cell head and neck cancer (SCHNC). Methods Results of published randomized controlled trials (RCTs) were pooled using Meta‐analyst0.988 software. Results A pooled analysis of 18 RCTs (20 comparisons) involving 3,192 patients detected a reduction in mortality for concomitant therapy compared with RT alone (odds ratio (OR), 0.62; 95% confidence interval (CI), 0.52–0.74; relative risk, 0.83; risk reduction, 11%; p < .00001). Platinum‐based regimens involving 1,514 patients from nine trials (10 comparisons) were most effective (OR, 0.57; 95% CI, 0.46–0.71; p < .00001; risk reduction, 12%). Concomitant therapy produced more acute adverse effects than RT alone. Conclusion Platinum‐based concomitant CT and RT is superior to conventional RT alone in improving survival in locally advanced SCHNC. Subgroup analyses can be used to help in choosing the most appropriate concomitant regimen. © 2001 John Wiley & Sons, Inc. Head Neck 23: 579–589, 2001.

Journal

Head & Neck: Journal for the Sciences & Specialties of the Head and Neck – Wiley

Published: Jul 1, 2001

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