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References (61)
-
S. Davidson, G. Giesler (2010)
The multiple pathways for itch and their interactions with painTrends in Neurosciences, 33
-
Qin Liu, Zongxiang Tang, L. Surdenikova, Seungil Kim, Kush Patel, Andrew Kim, F. Ru, Y. Guan, H. Weng, Yixun Geng, B. Undem, M. Kollarik, Zhou-Feng Chen, D. Anderson, Xinzhong Dong (2009)
Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced PruritusCell, 139
-
T. Akiyama, Austin Merrill, M. Carstens, E. Carstens (2009)
Activation of Superficial Dorsal Horn Neurons in the Mouse by a PAR-2 Agonist and 5-HT: Potential Role in ItchThe Journal of Neuroscience, 29
-
S. Shimada, Kelly Shimada, J. Collins (2006)
Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2.European journal of pharmacology, 530 3
-
T. Akiyama, M. Carstens, E. Carstens (2011)
Transmitters and Pathways Mediating Inhibition of Spinal Itch-Signaling Neurons by Scratching and Other CounterstimuliPLoS ONE, 6
-
H. Mochizuki, M. Tashiro, M. Kano, Yumiko Sakurada, M. Itoh, K. Yanai (2003)
Imaging of central itch modulation in the human brain using positron emission tomographyPain, 105
-
S. Davidson, Xijing Zhang, ChulH Yoon, S. Khasabov, D. Simone, G. Giesler (2007)
The Itch-Producing Agents Histamine and Cowhage Activate Separate Populations of Primate Spinothalamic Tract NeuronsThe Journal of Neuroscience, 27
-
M. Valet, F. Pfab, T. Sprenger, A. Wöller, C. Zimmer, H. Behrendt, J. Ring, U. Darsow, T. Tölle (2008)
Cerebral processing of histamine-induced itch using short-term alternating temperature modulation--an FMRI study.The Journal of investigative dermatology, 128 2
-
L. Johanek, R. Meyer, R. Friedman, K. Greenquist, B. Shim, J. Borzan, T. Hartke, R. LaMotte, M. Ringkamp (2008)
A Role for Polymodal C-Fiber Afferents in Nonhistaminergic ItchThe Journal of Neuroscience, 28
-
B. Namer, R. Carr, L. Johanek, M. Schmelz, H. Handwerker, M. Ringkamp (2008)
Separate peripheral pathways for pruritus in man.Journal of neurophysiology, 100 4
-
Jen-Chuen Hsieh, Ö. Hägermark, Mona Ståhle-Bäckdahl, K. Ericson, L. Eriksson, Sharon Stone-Elander, Martin Ingvar (1994)
Urge to scratch represented in the human cerebral cortex during itch.Journal of neurophysiology, 72 6
-
L. Johanek, R. Meyer, T. Hartke, J. Hobelmann, D. Maine, R. LaMotte, M. Ringkamp (2007)
Psychophysical and Physiological Evidence for Parallel Afferent Pathways Mediating the Sensation of ItchThe Journal of Neuroscience, 27
-
D. Andrew, A. Craig (2001)
Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itchNature Neuroscience, 4
-
R. LaMotte, S. Shimada, Barry Green, Daniel Zelterman (2009)
Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.Journal of neurophysiology, 101 3
-
S. Davidson, Xijing Zhang, S. Khasabov, D. Simone, G. Giesler (2008)
Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus.Journal of neurophysiology, 100 4
-
Lina Herde, C. Forster, M. Strupf, H. Handwerker (2007)
Itch induced by a novel method leads to limbic deactivations a functional MRI study.Journal of neurophysiology, 98 4
-
O. Hyndman, J. Wolkin (1943)
ANTERIOR CHORDOTOMY: FURTHER OBSERVATIONS ON PHYSIOLOGIC RESULTS AND OPTIMUM MANNER OF PERFORMANCEJournal of Nervous and Mental Disease, 50
-
Qin Liu, H. Weng, Kush Patel, Zongxiang Tang, H. Bai, M. Steinhoff, Xinzhong Dong (2011)
The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and HyperalgesiaScience Signaling, 4
-
Xijing Zhang, H. Wenk, A. Gokin, C. Honda, G. Giesler (1999)
Physiological studies of spinohypothalamic tract neurons in the lumbar enlargement of monkeys.Journal of neurophysiology, 82 2
-
R. Burstein, R. Dado, K. Cliffer, G. Giesler (1991)
Physiological characterization of spinohypothalamic tract neurons in the lumbar enlargement of rats.Journal of neurophysiology, 66 1
-
Yan-Gang Sun, Zhong-qiu Zhao, Xiu-Li Meng, Jun Yin, Xian-Yu Liu, Zhou-Feng Chen (2009)
Cellular Basis of Itch SensationScience, 325
-
N. Imamachi, G. Park, Hyosang Lee, D. Anderson, M. Simon, A. Basbaum, Sang-kyou Han (2009)
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanismsProceedings of the National Academy of Sciences, 106
-
H. Handwerker, C. Forster, C. Kirchhoff (1991)
Discharge patterns of human C-fibers induced by itching and burning stimuli.Journal of neurophysiology, 66 1
-
M. Schmelz, K. Michael, C. Weidner, R. Schmidt, H. Torebjörk, H. Handwerker (2000)
Which nerve fibers mediate the axon reflex flare in human skin?NeuroReport, 11
-
Frauke Kosteletzky, B. Namer, C. Forster, H. Handwerker (2009)
Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine.Acta dermato-venereologica, 89 3
-
D. Simone, Xijing Zhang, Jun Li, Jun-Ming Zhang, C. Honda, R. LaMotte, G. Giesler (2004)
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.Journal of neurophysiology, 91 1
-
V. Reddy, S. Shimada, Parul Sikand, R. LaMotte, E. Lerner (2010)
Cathepsin S elicits itch and signals via protease-activated receptors.The Journal of investigative dermatology, 130 5
-
Yang Liu, O. Samad, Ling Zhang, Bo Duan, Qingchun Tong, Cláudia Lopes, R. Ji, B. Lowell, Qiufu Ma (2010)
VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress ItchNeuron, 68
-
Salil Patel, Shinji Ohara, Patrick Dougherty, R. Gracely, Frederick Lenz (2006)
Psychophysical elements of place and modality specificity in the thalamic somatic sensory nucleus (ventral caudal, vc) of awake humans.Journal of neurophysiology, 95 2
-
A. Ikoma, M. Steinhoff, S. Ständer, G. Yosipovitch, M. Schmelz (2006)
The neurobiology of itchNature Reviews Neuroscience, 7
-
M. Schmelz, R. Schmidt, A. Bickel, H. Handwerker, H. Torebjörk (1997)
Specific C-Receptors for Itch in Human SkinThe Journal of Neuroscience, 17
-
R. Tuckett (1982)
Itch evoked by electrical stimulation of the skin.The Journal of investigative dermatology, 79 6
-
Parul Sikand, S. Shimada, B. Green, R. LaMotte (2009)
Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhagePAIN®, 144
-
S. Mikula, Issac Trotts, James Stone, E. Jones (2007)
Internet-enabled high-resolution brain mapping and virtual microscopyNeuroImage, 35
-
G. Yosipovitch, M. Greaves, A. Fleischer, F. McGlone (2004)
Itch : Basic Mechanisms and Therapy -
Sang-kyou Han, V. Mancino, M. Simon (2006)
Phospholipase Cβ 3 Mediates the Scratching Response Activated by the Histamine H1 Receptor on C-Fiber Nociceptive NeuronsNeuron, 52
-
E. Carstens, M. Carstens, C. Simons, S. Jinks (2010)
Dorsal horn neurons expressing NK-1 receptors mediate scratching in ratsNeuroReport, 21
-
M. Schmelz, M. Schmelz, R. Schmidt, C. Weidner, M. Hilliges, H. Torebjörk, H. Handwerker (2003)
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.Journal of neurophysiology, 89 5
-
Yan-Gang Sun, Zhou-Feng Chen (2007)
A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cordNature, 448
-
S. Ross, Alan Mardinly, Alejandra McCord, Jonathan Zurawski, Sonia Cohen, C. Jung, Linda Hu, Stephanie Mok, A. Shah, Erin Savner, Christos Tolias, Román Corfas, Suzhen Chen, Perrine Inquimbert, Yi Xu, R. Mcinnes, F. Rice, G. Corfas, Qiufu Ma, C. Woolf, M. Greenberg (2010)
Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant MiceNeuron, 65
-
D. Simone, M. Alreja, R. LaMotte (1991)
Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine.Somatosensory & motor research, 8 3
-
Xijing Zhang, S. Davidson, G. Giesler (2006)
Thermally Identified Subgroups of Marginal Zone Neurons Project to Distinct Regions of the Ventral Posterior Lateral Nucleus in RatsThe Journal of Neuroscience, 26
-
A. Drzezga, U. Darsow, R. Treede, H. Siebner, Max Frisch, F. Munz, F. Weilke, Johannes Ring, M. Schwaiger, P. Bartenstein (2001)
Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studiesPain, 92
-
T. Akiyama, M. Carstens, Earl Carstens (2010)
Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice.Journal of neurophysiology, 104 5
-
P. Shapiro, C. Braun (1987)
Unilateral pruritus after a stroke.Archives of dermatology, 123 11
-
Alexandru Papoiu, R. Coghill, R. Kraft, Hui Wang, G. Yosipovitch (2012)
A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itchNeuroImage, 59
-
T. Akiyama, M. Carstens, E. Carstens (2009)
Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch.Journal of neurophysiology, 102 4
-
G. Mann (1905)
ON THE THALAMUS *British Medical Journal, 1
-
M. Lagerström, K. Rogóż, B. Abrahamsen, E. Persson, B. Reinius, K. Nordenankar, Caroline Ölund, Casey Smith, J. Mendez, Zhou-Feng Chen, J. Wood, Å. Wallén-Mackenzie, K. Kullander (2010)
VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and ItchNeuron, 68
-
Parul Sikand, Xinzhong Dong, R. LaMotte (2011)
BAM8–22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine ReleaseThe Journal of Neuroscience, 31
-
A. Ikoma, H. Handwerker, Y. Miyachi, M. Schmelz (2005)
Electrically evoked itch in humansPain, 113
-
S. Davidson, Xijing Zhang, S. Khasabov, D. Simone, G. Giesler (2009)
Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neuronsNature Neuroscience, 12
-
W. Shim, M. Tak, Mi-Hyun Lee, Minjung Kim, Minkyung Kim, J. Koo, Chang-Hun Lee, Misook Kim, U. Oh (2007)
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2 and 12-LipoxygenaseThe Journal of Neuroscience, 27
-
J. Lipski (1981)
Antidromic activation of neurones as an analytic tool in the study of the central nervous systemJournal of Neuroscience Methods, 4
-
J. Ranck (1975)
Which elements are excited in electrical stimulation of mammalian central nervous system: A reviewBrain Research, 98
-
S. Leknes, Susanna Bantick, C. Willis, J. Wilkinson, R. Wise, I. Tracey (2007)
Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.Journal of neurophysiology, 97 1
-
Sarah Wilson, K. Gerhold, Amber Bifolck-Fisher, Qin Liu, Kush Patel, Xinzhong Dong, D. Bautista (2011)
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itchNature neuroscience, 14
-
V. Reddy, Aurel Iuga, S. Shimada, R. LaMotte, E. Lerner (2008)
Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated ReceptorsThe Journal of Neuroscience, 28
-
M. Ringkamp, R. Schepers, S. Shimada, L. Johanek, T. Hartke, J. Borzan, B. Shim, R. LaMotte, R. Meyer (2011)
A Role for Nociceptive, Myelinated Nerve Fibers in Itch SensationThe Journal of Neuroscience, 31
-
R. Thurmond, E. Gelfand, P. Dunford (2008)
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistaminesNature Reviews Drug Discovery, 7
-
H. Mochizuki, N. Sadato, D. Saito, H. Toyoda, M. Tashiro, N. Okamura, K. Yanai (2007)
Neural correlates of perceptual difference between itching and pain: A human fMRI studyNeuroImage, 36
- Publisher
- The American Physiological Society
- Copyright
- Copyright © 2012 the American Physiological Society
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- DOI
- 10.1152/jn.00206.2012
- pmid
- 22723676
- Publisher site
- See Article on Publisher Site
Abstract
Itch of peripheral origin requires information transfer from the spinal cord to the brain for perception. Here, primate spinothalamic tract (STT) neurons from lumbar spinal cord were functionally characterized by in vivo electrophysiology to determine the role of these cells in the transmission of pruriceptive information. One hundred eleven STT neurons were identified by antidromic stimulation and then recorded while histamine and cowhage (a nonhistaminergic pruritogen) were sequentially applied to the cutaneous receptive field of each cell. Twenty percent of STT neurons responded to histamine, 13% responded to cowhage, and 2% responded to both. All pruriceptive STT neurons were mechanically sensitive and additionally responded to heat, intradermal capsaicin, or both. STT neurons located in the superficial dorsal horn responded with greater discharge and longer duration to pruritogens than STT neurons located in the deep dorsal horn. Pruriceptive STT neurons discharged in a bursting pattern in response to the activating pruritogen and to capsaicin. Microantidromic mapping was used to determine the zone of termination for pruriceptive STT axons within the thalamus. Axons from histamine-responsive and cowhage-responsive STT neurons terminated in several thalamic nuclei including the ventral posterior lateral, ventral posterior inferior, and posterior nuclei. Axons from cowhage-responsive neurons were additionally found to terminate in the suprageniculate and medial geniculate nuclei. Histamine-responsive STT neurons were sensitized to gentle stroking of the receptive field after the response to histamine, suggesting a spinal mechanism for alloknesis. The results show that pruriceptive information is encoded by polymodal STT neurons in histaminergic or nonhistaminergic pathways and transmitted to the ventrobasal complex and posterior thalamus in primates. dorsal horn pain thalamus histamine cowhage Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print June 20, 2012 , doi: 10.1152/jn.00206.2012 AJP - JN Physiol September 15, 2012 vol. 108 no. 6 1711-1723 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: jn.00206.2012v1 108/6/1711 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Davidson, S. Articles by Giesler, G. J. PubMed PubMed citation Articles by Davidson, S. Articles by Giesler, G. J. Related Content Load related web page information Current Content September 15, 2012 Alert me to new issues of AJP - JN Physiol About the Journal Calls for Papers Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0022-3077 Online ISSN: 1522-1598 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview(); } catch(err) {} var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-30"); pageTracker._setDomainName(".physiology.org"); pageTracker._trackPageview(); } catch(err) {}
Journal
Journal of Neurophysiology – The American Physiological Society
Published: Sep 15, 2012