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- Publisher
- Springer Journals
- Copyright
- Copyright © 2016 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Biomedicine; Biomedicine, general; Cancer Research
- ISSN
- 1474-175X
- eISSN
- 1474-1768
- DOI
- 10.1038/nrc.2016.73
- Publisher site
- See Article on Publisher Site
Abstract
Resting or quiescent adult fibroblasts are indolent and probably remnants of mesenchymal cells during organ development. Resting fibroblasts serve as precursors of activated fibroblasts including myofibroblasts. Resting fibroblasts share some features with adult tissue stem cells and embryonic stem cells. Activated fibroblasts can differentiate into adipocytes and chondrocytes and exhibit the potential to be programmed into induced pluripotent stem cells, in part because of their epigenetic and transcriptomic state, which favours their reprogramming efficiency. Resting fibroblasts can differentiate into active fibroblasts that are synthetically active and can generate growth factors and extracellular matrix. Cancer metabolism is influenced by activated fibroblasts. Activated fibroblasts recruit immune cells and regulate tumour immunity. Activated fibroblasts modulate chemoresistance. Angiogenesis can be stimulated by activated fibroblasts. It is now generally accepted that cancer-associated fibroblasts are a heterogeneous population with distinct functions. Cancer-associated fibroblasts can serve as positive and negative regulators of tumour progression.
Journal
Nature Reviews Cancer – Springer Journals
Published: Aug 23, 2016