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Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia

Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia ORIGINAL ARTICLE Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia Stephen M. Eggan, PhD; Takanori Hashimoto, MD, PhD; David A. Lewis, MD Context: Cannabis use is associated with both im- long-term exposure to haloperidol, olanzapine, or paired cognitive functions, including working memory, placebo. and an increased risk of schizophrenia. Schizophrenia is characterized by impairments in working memory that Main Outcome Measures: Optical density measures are associated with reduced-aminobutyric acid (GABA) of CB1R mRNA expression and protein levels and cor- neurotransmission in the dorsolateral prefrontal cortex. relations with previously reported glutamic acid decar- The cannabinoid 1 receptor (CB1R) is highly expressed boxylase 67 and cholecystokinin mRNA measures. in the dorsolateral prefrontal cortex, is contained in the axon terminals of a subpopulation of perisomatic- Results: Levels of CB1R mRNA were significantly lower targeting GABA neurons, and, when activated, sup- by 14.8% in the subjects with schizophrenia. Similarly, presses the release of GABA. CB1R protein levels, assessed by radioimmunocytochem- istry and standard immunocytochemistry, were signifi- Objective: To determine the potential relationship be- cantly decreased by 11.6% and 13.9%, respectively. Group tween CB1R signaling and altered GABA neurotransmis- differences in CB1R mRNA levels were significantly cor- sion in schizophrenia http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia

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References (80)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archpsyc.65.7.772
pmid
18606950
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia Stephen M. Eggan, PhD; Takanori Hashimoto, MD, PhD; David A. Lewis, MD Context: Cannabis use is associated with both im- long-term exposure to haloperidol, olanzapine, or paired cognitive functions, including working memory, placebo. and an increased risk of schizophrenia. Schizophrenia is characterized by impairments in working memory that Main Outcome Measures: Optical density measures are associated with reduced-aminobutyric acid (GABA) of CB1R mRNA expression and protein levels and cor- neurotransmission in the dorsolateral prefrontal cortex. relations with previously reported glutamic acid decar- The cannabinoid 1 receptor (CB1R) is highly expressed boxylase 67 and cholecystokinin mRNA measures. in the dorsolateral prefrontal cortex, is contained in the axon terminals of a subpopulation of perisomatic- Results: Levels of CB1R mRNA were significantly lower targeting GABA neurons, and, when activated, sup- by 14.8% in the subjects with schizophrenia. Similarly, presses the release of GABA. CB1R protein levels, assessed by radioimmunocytochem- istry and standard immunocytochemistry, were signifi- Objective: To determine the potential relationship be- cantly decreased by 11.6% and 13.9%, respectively. Group tween CB1R signaling and altered GABA neurotransmis- differences in CB1R mRNA levels were significantly cor- sion in schizophrenia

Journal

JAMA Psychiatry – American Medical Association

Published: Jul 1, 2008

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